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Tomoaki Nishikawa

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Featured researches published by Tomoaki Nishikawa.

Bioscience, Biotechnology, and Biochemistry | 2002

Inhibition by ajoene of skin-tumor promotion in mice.

Tomoaki Nishikawa; Norihiko Yamada; Atsuhiko Hattori; Hiroyuki Fukuda; Tsuchiyoshi Fujino

Ajoene, a major compound containing sulfur in oil-macerated garlic products, inhibited in a two-stage carcinogenesis test on mouse skin. Treatment with ajoene suppressed skin tumor formation, depending on the amount. In particular, the group treated with 250 μg of ajoene had only 4.9% the number of tumors per mouse compared with the control group at 18 weeks.

Bioscience, Biotechnology, and Biochemistry | 2013

Enhancement of Intestinal IgA Production by Ajoene in Mice

Yuki Washiya; Tomoaki Nishikawa; Tsuchiyoshi Fujino

We investigated the effects of ajoene on intestinal IgA production. Ajoene (1.35, 4.5, and 13.5 µg/kg/d) was administered to mice for 4 weeks. The fecal IgA level in the 13.5 µg/kg/d group increased after 3 weeks. The intestinal IgA level also increased in a dose-dependent manner upon ajoene administration. An oil-macerated garlic extract, with 1500 µg/g of ajoene, enhanced the intestinal IgA production.

Bioscience, Biotechnology, and Biochemistry | 2001

Protective Effect of Ajoene on Acetaminophen-induced Hepatic Injury in Mice

Atsuhiko Hattori; Norihiko Yamada; Tomoaki Nishikawa; Hiroyuki Fukuda; Tsuchiyoshi Fujino

Journal of Nutritional Science and Vitaminology | 2005

Antidiabetic Effects of Ajoene in Genetically Diabetic KK-Ay Mice

Atsuhiko Hattori; Norihiko Yamada; Tomoaki Nishikawa; Hiroyuki Fukuda; Tsuchiyoshi Fujino

Biological & Pharmaceutical Bulletin | 2006

Prophylactic Effects of Ajoene on Cerebral Injury in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)

Norihiko Yamada; Atsuhiko Hattori; Tomoaki Nishikawa; Hiroyuki Fukuda; Tsuchiyoshi Fujino

生薬學雜誌 | 2005

Antibacterial Effect of Ajoene on Helicobacter pylori in Mongolian gerbils

Mamiko Kawase; Norihiko Yamada; Tomoaki Nishikawa; Atsuhiko Hattori; Hiroyuki Fukuda; Tsuchiyoshi Fujino

Journal of The Japanese Society for Food Science and Technology-nippon Shokuhin Kagaku Kogaku Kaishi | 2018

Identification of a Hyperuricemia Inhibitor in Coffee Bean Extract Decreased by the Degassing Process and Its Mechanism

Yuki Washiya; Tomoaki Nishikawa; Tsuchiyoshi Fujino

Journal of The Japanese Society for Food Science and Technology-nippon Shokuhin Kagaku Kogaku Kaishi | 2016

Anxiolytic Effect of Non-degassed Roasted Coffee Bean Extracts in Mouse

Yuki Washiya; Tomoaki Nishikawa; Tsuchiyoshi Fujino

Journal for The Integrated Study of Dietary Habits | 2016

Suppressive effects of non-degassed roasted coffee bean extracts on plasma and hepatic triglyceride elevation in mice fed a high fat diet

Tomoaki Nishikawa; Yuki Washiya; Tsuchiyoshi Fujino

Journal of The Japanese Society for Food Science and Technology-nippon Shokuhin Kagaku Kogaku Kaishi | 2014

Enhancement of Serum Immunoglobulins G and A Production by Non-degassed Roasted Coffee Bean Extract

Yuki Washiya; Tomoaki Nishikawa; Tsuchiyoshi Fujino

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Tsuchiyoshi Fujino

Mie University

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Hiroyuki Fukuda

Yokohama City University Medical Center

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