Tomoichi Setogawa

Postoperative Instillation of Low-Dose Mitomycin C in the Treatment of Primary Pterygium

Eighty patients (99 eyes) with primary pterygia were treated with excision, with or without additional therapy, and were followed up for three to eight years after treatment. Of 29 eyes that underwent excision and postoperative instillation of 0.02% mitomycin C, there were only two recurrences. The other eyes were treated with excision only, excision and radiation, or excision and 0.04% mitomycin C. Instillation of 0.02% mitomycin C reduced the recurrence rate significantly (P less than .01). Only one of the 29 eyes (3%) treated with excision and 0.02% mitomycin C had a complication, the lowest rate of all groups postoperatively. We found the postoperative instillation of 0.02% mitomycin C, twice a day for five days, to be effective and safe in the treatment of primary pterygium.

Ocular symptoms of Moyamoya disease

We examined four patients with moyamoya disease who had ocular symptoms. The diagnosis of the disease was based on an abnormal vascular network in the cerebral basilar region, observed by carotid angiography. One patient had amaurosis fugax. A second patient demonstrated bilaterally decreased visual acuity and visual spatial agnosia. The other two patients had homonymous hemianopsia; one also had transient diplopia and the other had temporal pallor of the optic disks. We found that patients with moyamoya disease exhibited various ocular symptoms but had few abnormal intraocular findings.

Herpes zoster ophthalmicus Complicated by Hyphema and Hemorrhagic Glaucoma

We treated two patients with herpes zoster ophthalmicus in whom hyphema and hemorrhagic glaucoma occurred. Case 1 complained of facial skin eruption, and was given intravenous acyclovir for 7 days. Hyphema and high intraocular pressure occurred in the left eye 10 days after the onset of the skin eruption. Case 2 had severe pain and blisters on her face, and was given intravenous acyclovir for 7 days. An intracameral hemorrhage and glaucoma developed in the right eye 15 days after the onset of the skin lesion. Intravenous acyclovir may be necessary for longer than 7-day periods if the iridocyclitis remains.

Vortex Veins in the Macula

A 54-year-old man with diabetes mellitus had abnormal choroidal vessels in the right eye. Whirled tributaries, the choroidal part of the vortex vein, and the scleral canal beneath the central foveal area were visible. This is a rare case of vortex veins in the macula.

Concomitant Granular Dystrophy of the Cornea and Cone Dystrophy (With 1 color plate)

We examined a 52-year-old man with bilateral symmetric lesions of the cornea and fundus. The corneal lesions were compatible with granular dystrophy, and the fundus lesions were consistent with cone dystrophy. The simultaneous occurrence of these dystrophies may be uncommon.

Leber’s Miliary Aneurysms in a 63-Year-Old Woman: Concurrence of Regression and Active Lesions (with 1 Color Plate)

We examined a 63-year-old woman with retinal telangiectasia, aneurysms, a ring of fatty exudate, and pigmented chorioretinal atrophic lesions in the right eye. Lebers miliary aneurysm was diagnosed, although this disorder is known to have a high incidence mainly in young boys. The pigmented chorioretinal scars appear to be sequelae of spontaneously regressing retinal lesions.

Combined hamartoma of the retina and retinal pigment epithelium of the juxtapapillary retina and optic disc.

An 11-year-old Japanese girl had a greenish-gray, slightly elevated lesion at the optic disc and juxtapapillary retina of the right eye that was diagnosed as a combined hamartoma of the retina and retinal pigment epithelium. A gliotic epiretinal membrane partially covered the lesion. Tortuous retinal vessels, which leaked fluorescein dye, were noted ophthalmoscopically. The lesion remained stable during a follow-up period of 1 year. After reviewing the Japanese literature, we concluded that the combined hamartoma may not be as rare in Japan as previously thought.

Ocular injuries by autostimulation in mentally retarded and nearly blind children

Recently, the authors treated two mentally retarded and nearly blind children whose eyes were injured by autostimulation. Case 1, who has Jouberts syndrome associated with Lebers congenital amaurosis, continued to press his left eye with his hands, and a severe corneal ulcer ensued. Case 2, who is suspected of having optic atrophy or cortical blindness, looked too closely at a bright light and burned his eyelid.

Retinal Microaneurysms in a Patient with Drug-Induced Aplastic Anemia

We examined ophthalmologically a patient with drug-induced aplastic anemia. The patient had good visual acuity and full visual fields, but small round hemorrhages and small red dots were seen ophthalmoscopically in both fundi. Fluorescein angiography revealed punctate hyperfluorescence from the early to late phases, indicating microaneurysms. We believe that retinal microaneurysms are not rare in association with anemia.

Affinity of Drugs for Dopa-Auto-Oxidation Melanin and Tyrosinase-Catalyzed Dopa-Melanin in vitro

We examined spectrophotometrically the ability of drugs to bind with dopa-auto-oxidation melanin or tyrosinase-catalyzed dopa-melanin. Each drug, at 5 X 10(-5) M, was incubated at 37 degrees C for 8 h with 0.4 mg of synthetic melanins in 20 mM potassium phosphate buffer at pH 7.0 or in 20 mM acetate buffer at pH 4.8. Chloroquine, thioridazine, befunolol, pindolol, daunomycin and 5-fluorouracil bound to melanin at pH 7.0 and 4.8. Methotrexate bound to melanin at pH 4.8, but not at pH 7.0. Pilocarpine, epinephrine, acyclovir, vincristine and colchicine did not bind to dopa-auto-oxidation melanin or tyrosinase-catalyzed dopa-melanin.