Tomoji Sakamoto

Chondrosarcoma of the jaw: Report of two cases

Les 2 malades ont ete suivies pendant 7 ans. On discute les possibilites de la radiotherapie et de la chimiotherapie comme adjuvants de la chirurgie

A biochemical evaluation of oral squamous cell carcinoma growth by measurement of specific activity of succinate dehydrogenase in the subrenal capsule assay

An auxiliary method for determination of chemosensitivity with the subrenal capsule assay (SRCA) was developed in which the specific activity of succinate dehydrogenase (SD) of tumor implanted beneath the renal capsule is measured. The appropriate conditions for measuring the specific activity of SD were determined. The chemosensitivity of tumors, derived from six xenograft lines originating from oral squamous cell carcinomas, to peplomycin (PEP), cisplatin (CDDP), and 5-fluorouracil (5-FU) were evaluated by the SRCA and the nude mouse assay (NMA). The chemosensitivity evaluated by NMA displayed a higher degree of correlation with that determined by the improved SRCA than with that determined by the conventional SRCA. The correlations between overall accuracy of prediction with the NMA and those with the conventional SRCA and the improved SRCA were 72.2% and 88.9%, respectively. These findings suggest that our new assay may be useful for evaluation of chemosensitivity in the SRCA.

Long term clinical observation of osteomyelitis of the jaw

The incidence of osteomyelitis of the jaw has been reduced because of the recent progress in antibiotic therapy. Unlike typical cases recorded in the usual textbooks, very prolonged and difficult types of chronic osteomyelitis are also encountered. In these cases, it is difficult to recover completely by means of antibiotic therapy alone, and therefore surgical intervention is inevitable.Among 2020 cases recorded in the inpatient clinic from August 1974 to February 1987, 180 cases (8.9%) were cases of inflammatory disease (Table 1), and 46 out of 180 cases were diagnosed as osteomyelitis (25. 6%). Of the 46 cases of osteomyelitis 22 of them were classified as chronic osteomyelitis (47.8%), 13 as acute osteomyelitis (28.3%), and 8 as radiation osteomyelitis (17.4%) (Table 2).The three cases presented in this study required surgical intervention. In one case of chronic osteomyelitis surgical treatment, extraction of a tooth and sequestrectomy, was performed. Another two cases, which occurred in patients with radiation osteomyelitis, required sequestrectomy and segmental mandibulectomy, respectively.

Clinical course and evaluation of immediate mandibular reconstruction using autogenous iliac bone graft after the extirpation of malignant tumor.

Reconstructive surgery was performed for five patients suffering malignant tumors in oral cavity using autogenous iliac bone graft immediately following mandibular resection. After a careful three year follow up in any case, grafted bone was found to retain its vitality and no infection or recurrence was any observed. The results were satisfactory not only esthetically but functionally. These cases showed the usefulness of autogenous graft with iliac crest to immediately reconstruct the defects caused by mandibular resection.