Tomotaka Yoshiyama
Osaka City University
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Publication
Featured researches published by Tomotaka Yoshiyama.
Journal of Atherosclerosis and Thrombosis | 2018
Tomotaka Yoshiyama; Kenichi Sugioka; Takahiko Naruko; Masashi Nakagawa; Nobuyuki Shirai; Masahiko Ohsawa; Minoru Yoshiyama; Makiko Ueda
Aim: Neopterin is an activation marker for monocytes/macrophages. We prospectively investigated the predictive value of plasma neopterin levels on 2-year and long-term cardiovascular events in patients with stable angina pectoris (SAP) undergoing coronary stent implantation. Methods: We studied 123 consecutive patients with SAP who underwent primary coronary stenting (44 patients with bare metal stent: BMS group and 79 with drug-eluting stent: DES group). Plasma neopterin levels were measured on admission using HPLC. Moreover, one frozen coronary artery specimen after DES and three frozen coronary specimens after BMS were obtained by autopsy or endarterectomy, followed by immunohistochemical staining for neopterin. Results: Plasma neopterin levels were significantly higher in patients with cardiovascular events than in those without them (P < 0.001). In subgroup analyses, higher levels of plasma neopterin in patients with cardiovascular events (P < 0.001) and a positive correlation between neopterin levels and late lumen loss after stenting (P = 0.008) were observed in the BMS group but not in the DES group (P = 0.53 and P = 0.17, respectively). In long-term cardiovascular events, multivariate Cox regression analysis identified the significance of the high-neopterin group as independent determinants of cardiovascular events (hazard ratio, 2.225; 95% CI, 1.283–3.857; P = 0.004). Immunohistochemical staining showed abundant neopterin-positive macrophages in the neointima after BMS implantation but no neopterin-positive macrophages in the neointima after DES implantation. Conclusion: These findings suggest that neopterin is associated with cardiovascular events after coronary stent implantation in patients with SAP. However, there might be a strong association between neopterin and cardiovascular events after BMS but not after DES in these patients.
Europace | 2018
Kenji Shimeno; Tomotaka Yoshiyama; Yukio Abe; Kanako Akamatsu; Syunsuke Kagawa; Tsukasa Matsushita; Masanori Matsuo; Yoshiki Matsumura; Ryo Matsumoto; Kimio Kamimori; Takahiko Naruko; Atsuhi Doi; Masahiko Takagi; Minoru Yoshiyama
Aims Although right ventricular septal pacing is thought to be more effective in minimizing pacing-induced left ventricular dysfunction, the accurate way to anchor the lead to the right ventricular septum (RVS) has not been established. Our aim was to clarify the usefulness of right ventriculography (RVG) to aid accurate anchoring of the lead to the RVS. Methods and results Eighty-four patients who underwent pacemaker implantation were enrolled. We anchored the lead to the RVS by using an RVG image obtained at a 30° right anterior oblique view as a reference. We confirmed the actual lead position by performing computed tomography after the procedure and examined the characteristics of the paced QRS complex. Of the 81 patients, except 3 patients whose leads were anchored to the apex due to high pacing thresholds in the RVS, the leads were successfully anchored to the RVS in the 79 (98%) patients, and the number of leads placed in the high-, mid-, and low-RVS was 3 (4%), 58 (73%), and 18 (23%), respectively. The paced QRS duration in these 79 patients was 140 ± 13 ms. The paced QRS duration from mid-RVS was considerably narrower than that from high- or low-RVS (137 ± 12 ms vs. 146 ± 12 ms; P = 0.012). Conclusion Right ventriculography was very useful in aiding accurate anchoring of the lead to the RVS. Further, pacing from mid-RVS may be more effective in minimizing the QRS duration than pacing from other RVS sites.
Heart and Vessels | 2018
Atsushi Doi; Masahiko Takagi; Hisashi Katayama; Tomotaka Yoshiyama; Yusuke Hayashi; Hiroaki Tatsumi; Minoru Yoshiyama
Europace | 2018
Atsushi Doi; H Katayama; Tomotaka Yoshiyama; Yusuke Hayashi; Hiroaki Tatsumi; Minoru Yoshiyama
Europace | 2017
M. Matsuo; Kenji Shimeno; Kanako Akamatsu; S. Kagawa; Tsukasa Matsushita; Tomotaka Yoshiyama; Ryo Matsumoto; Yoshiki Matsumura; Yukio Abe; Kimio Kamimori; Takahiko Naruko
Europace | 2017
Kenji Shimeno; Kanako Akamatsu; S. Kagawa; Tsukasa Matsushita; M. Matsuo; Tomotaka Yoshiyama; Yoshiki Matsumura; Ryo Matsumoto; Yukio Abe; Kimio Kamimori; Takahiko Naruko
Europace | 2017
Tomotaka Yoshiyama; K. Simeno; Kanako Akamatsu; S. Kagawa; Tsukasa Matsushita; M. Matsuo; Ryo Matsumoto; Yoshiki Matsumura; Yukio Abe; Kimio Kamimori; Takahiko Naruko
Circulation | 2016
Tsukasa Matsushita; Yoshiki Mastumura; Tomotaka Yoshiyama; Kenji Simeno; Ryo Mastumoto; Yukio Abe; Kimio Kamimori; Takahiko Naruko; Kenichi Sugioka; Masashi Nakagawa; Minoru Yoshiyama; Makiko Ueda
Circulation | 2016
Tsukasa Matsushita; Yoshiki Matsumura; Tomotaka Yoshiyama; Kenji Shimeno; Ryo Matsumoto; Yukio Abe; Kimio Kamimori; Takahiko Naruko; Kenichi Sugioka; Masashi Nakagawa; Minoru Yoshiyama; Makiko Ueda
Circulation | 2014
Tomotaka Yoshiyama; Kei Yunoki; Ryushi Komatsu; Kazuo Haze; Takahiko Naruko; Kenichi Sugioka; Masashi Nakagawa; Mayumi Inaba; Minoru Yoshiyama; Kagehiro Uchida; Tatsuya Sawamura; Makiko Ueda