Tomoya Miura
Japan Tobacco
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Tomoya Miura.
Bioorganic & Medicinal Chemistry Letters | 2009
Makoto Shiozaki; Hiroto Imai; Katsuya Maeda; Tomoya Miura; Katsutaka Yasue; Akira Suma; Masahiro Yokota; Yosuke Ogoshi; Julia Haas; Andrew M. Fryer; Ellen R. Laird; Nicole M. Littmann; Steven W. Andrews; John A. Josey; Takayuki Mimura; Yuichi Shinozaki; Hiromi Yoshiuchi; Takashi Inaba
A series of 1-sulfonylaminocyclopropanecarboxylates was synthesized as ADAMTS-5 (Aggrecanase-2) inhibitors. After an intensive investigation of the central cyclopropane core including its absolute stereochemistry and substituents, we found compound 22 with an Agg-2 IC50=7.4 nM, the most potent ADAMTS-5 inhibitor reported so far.
Bioorganic & Medicinal Chemistry Letters | 2009
Makoto Shiozaki; Katsuya Maeda; Tomoya Miura; Yosuke Ogoshi; Julia Haas; Andrew M. Fryer; Ellen R. Laird; Nicole M. Littmann; Steven W. Andrews; John A. Josey; Takayuki Mimura; Yuichi Shinozaki; Hiromi Yoshiuchi; Takashi Inaba
A series of N-substituted sulfonylamino-alkanecarboxylate ADAMTS-5 (Aggrecanase-2) inhibitors has been synthesized and the in vitro enzyme SAR is discussed. This report is the first example of carboxylate-based ADAMTS-5 inhibitors which show strong potency of IC(50)<0.1muM with excellent selectivity over MMP-1 and TACE.
Archive | 2007
Shinichi Kikuchi; Takuya Matsui; Teruhiko Inoue; Masakazu Terashita; Tomoya Miura; Takayuki Mimura; Kenji Fukui; Akihiko Takahashi
Archive | 2004
Hisashi Kawasaki; Tetsudo Kaya; Hiroto Imai; Tomoya Miura; Yukihiro Nomura; Hiroshi Chatani; Yoshifumi Ueda; Takayuki Mimura; Hiroyuki Iwamura
Archive | 2010
Satoru Noji; Makoto Shiozaki; Tomoya Miura; Yoshinori Hara; Hiroshi Yamanaka; Katsuya Maeda; Akimi Hori; Masafumi Inoue; Yasunori Hase
Archive | 2012
Tomoya Miura; Yosuke Ogoshi; Kazuhito Ueyama; Dai Motoda; Toshihiko Iwayama; Koichi Suzawa; Hironobu Nagamori; Hiroshi Ueno; Akihiko Takahashi; Kazuyuki Sugimoto
Archive | 2010
Satoru Noji; Makoto Shiozaki; Tomoya Miura; Yoshinori Hara; Hiroshi Yamanaka; Katsuya Maeda; Akimi Hori; Masafumi Inoue; Yasunori Hase
Archive | 2012
Tomoya Miura; Yosuke Ogoshi; Kazuhito Ueyama; Dai Motoda; Toshihiko Iwayama; Koichi Suzawa; Hironobu Nagamori; Hiroshi Ueno; Akihiko Takahashi; Kazuyuki Sugimoto
Archive | 2017
Akihiko Takahashi; Dai Motoda; Hironobu Nagamori; Hiroshi Ueno; Kazuhito Ueyama; Kazuyuki Sugimoto; Koichi Suzawa; Tomoya Miura; Toshihiko Iwayama; Yosuke Ogoshi
Archive | 2014
Kazuhito Ueyama; Dai Motoda; Toshihiko Iwayama; Koichi Suzawa; Hironobu Nagamori; Hiroshi Ueno; Akihiko Takahashi; Kazuyuki Sugimoto; Tomoya Miura; Yosuke Ogoshi
