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Tomoyasu Higashi

National Institute of Radiological Sciences

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Featured researches published by Tomoyasu Higashi.

Gene | 1997

CLONING AND SEQUENCING FOR THE LARGEST SUBUNIT OF CHINESE HAMSTER RNA POLYMERASE II GENE : IDENTIFICATION OF A MUTATION RELATED TO ABNORMAL INDUCTION OF SISTER CHROMATID EXCHANGES

Kimihiko Sugaya; Shun-ichi Sasanuma; Junko Nohata; Terumi Kimura; Etsuko Hongo; Tomoyasu Higashi; Mitsuoki Morimyo; Hideo Tsuji; Kazuei Mita

In order to analyze the mutation sites related to abnormal induction of sister chromatid exchanges (SCEs) in the RNA polymerase II largest subunit (RpII LS) gene of the Chinese hamster CHO-KI cell mutant, we have completely sequenced the whole region of the RpII LS cDNAs obtained from normal and mutant cells. By comparing both sequences, a mutation that results in an amino acid (aa) change in the RpII LS gene was found. This aa change was Pro (CCC) to Ser (TCC) at position 1006. Multiple alignment for aa sequences of RpII LS from various species revealed that this Pro residue was highly conserved throughout the eukaryotes. Considering the differences in physico-chemical properties between Pro and Ser residues, the Pro-->Ser substitution may alter the RpII LS structure.

Gene | 1997

Comprehensive cloning of Schizosaccharomyces pombe genes encoding translation elongation factors

Kazuei Mita; Mitsuoki Morimyo; Koichi Ito; Kimihiko Sugaya; Kanae Ebihara; Etsuko Hongo; Tomoyasu Higashi; Yasuko Hirayama; Yoshikazu Nakamura

Mutation Research | 2006

Radiation-induced germline mutations detected by a direct comparison of parents and first-generation offspring DNA sequences containing SNPs.

Jianyu Wu; Mitsuoki Morimyo; Etsuko Hongo; Tomoyasu Higashi; Masanori Okamoto; Akihiro Kawano; Yasushi Ohmachi

Archive | 1998

cDNA Catalog of Fission Yeast (Schizosaccharomyces pombe) and Its Application for Cloning of Mammalian DNA Repair Gene

Mitsuoki Morimyo; Kazuei Mita; Etsuko Hongo; Tomoyasu Higashi; Kimihiko Sugaya; Masahiro Ajimura; Masatake Yamauchi; Satsuki Tsuji; Woo-Yoon Park; Shun-ichi Sasanuma; Junko Nohata; Terumi Kimura; Hiromi Inoue; Yoshie Ishihara

Journal of Radiation Research | 2003

194 Radiation-induced Germ-line Mutations Detected by a Direct Comparison of Parents and Children DNA Sequences Containing SNPs(Mutation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)

Mitsuoki Morimyo; Etsuko Hongo; Tomoyasu Higashi; Kenu Go; Masanori Okamoto; Akihiro Kawano; Masatake Yamauchi; Satsuki Tsuji; Idumi Matsumoto; Riichirou Iritani; Yasushi Omachi; Yoshiya Shimada; Toshiaki Ogiu; Mayumi Nishimura; Mitsuru Nenoi

The Japan Radiation Research Society Annual Meeting Abstracts The 48th Annual Meeting of The Japan Radiation Research Society | 2005

Occurrence of spontaneous Notch1 deletions via illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in mouse thymocytes

Hideo Tsuji; Hiroko Ishii-Ohba; Eiko Kubo; Tomoyasu Higashi; Takanori Katube

The Japan Radiation Research Society Annual Meeting Abstracts The 47th Annual Meeting of The Japan Radiation Research Society | 2004

Involvement of Rag-dependent Illegitimate V(D)J Recombination and Rag-independent Microhomology-mediated Nonhomologous End-joining in the Formation of the 5' Deletion of Notch1 Gene in Radiation-induced Mouse Thymic Lymphomas

Hideo Tsuji; Hiroko Ishii-Ohba; Takanori Katsube; Tomoyasu Higashi

Archive | 2003

Radiation-induced germ-line mutations detected by a direct comparison of parents and children DNA sequences containing SNPs

Mitsuoki Morimyo; Etsuko Hongou; Tomoyasu Higashi; Go K; Izumi Matsumoto; Masanori Okamoto; Akihiro Kawano; Satsuki Tsuji

Journal of Radiation Research | 2002

Analysis of Radiation-induced Germline Mutation Using SNP Marker

Mitsuoki Morimyo; Etsuko Hongo; Tomoyasu Higashi; Kenu Go; Masanori Okamoto; Mitsuru Nenoi; Akihiro Kawano; Yoshiya Shimada; Mayumi Nishimura; Masatake Yamauchi; Satsuki Tsuji; Toshiaki Ogiu; Yasusi Ohmachi; Izumi Matsumoto; Riichiro Iritani

Journal of Radiation Research | 1998