Torbjörn Hillensjö

Outcome of IVF in Patients with Endometriosis in Comparison with Tubal-Factor Infertility

Purpose:The aim of this retrospective study was to compare the outcome of in vitro fertilization and embryo transfer in women with endometriosis and a control group with tubal-factor infertility.Methods:Forty-eight patients with endometriosis underwent 65 cycles of in vitro fertilization and embryo transfer at Huddinge University Hospital. The matched control group with tubal-factor infertility consisted of 98 cycles in 98 patients. These groups were retrospectively analyzed regarding stimulation, fertilization, embryo development, implantation, and pregnancy outcome.Results:The fertilization rate was significantly lower in women with endometriosis, but the cleavage, implantation, and pregnancy rates did not differ.Conclusions:Our results show that women with endometriosis have a lower fertilization rate compared with women with tubal-factor infertility. However, once the oocyte is fertilized, it seems that the preembryo has a normal chance of implantation, leading to similar pregnancy rates.

Application of single-needle blastomere biopsy in human preimplantation genetic diagnosis

We have tested and subsequently successfully applied a single‐needle approach to obtain blastomere biopsies from human preimplantation embryos for preimplantation genetic diagnosis (PGD).

Human chorionic gonadotropin patterns in early pregnancy after assisted reproduction

Background. Assisted reproduction implies increased risks of pathological pregnancy, necessitating close follow up of early pregnancy. The use of serum hCG levels two and three weeks after embryo transfer for prediction of pregnancy outcome after in vitro fertilization‐embryo transfer (IVF/ET) or gamete intrafallopian transfer (GIFT) was evaluated.

Epididymal and testicular sperm for intracytoplasmic sperm injection in the treatment of obstructive azoospermia

Background. The possibility of treating male infertility because of obstructive azoospermia has been poor, but intracytoplasmic sperm injection (1CSI) has given this type of infertility sufferer a new option.

Complex genetic counseling and exclusion of duchenne muscular dystrophy in a twin pregnancy after in vitro fertilization (IVF)

A twin pregnancy following in vitro ferilization-embryo transfer coincidentally at risk for the X-linked recessive Duchenne muscular dystrophy is described. Firsttrimester prenatal diagnosis by transabdominal chorionic villus samplings on the dichorionic placentae and molecular linkage analysis could exclude the disorder in both fetuses. Genetic counseling and prenatal diagnosis were particularly complex due to the twin pregnancy, the need for linkage analysis, and confined placental mosaicism 45,X/46XX in one of the fetuses. All parties should be aware that additional invasive diagnostic procedures in the second trimester might be required. It is proposed that, in similar situations, only one, arguably two, fertilized egg be transferred at a time to facilitate prenatal diagnosis and decision making for these rare couples. This problem, however, may be increasingly overcome by preimplantation diagnosis.