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Featured researches published by Töres Theorell.


The Lancet. Public health | 2017

Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe

Mika Kivimäki; Eeva Kuosma; Jane E. Ferrie; Ritva Luukkonen; Solja T. Nyberg; Lars Alfredsson; G. David Batty; Eric Brunner; Eleonor Fransson; Marcel Goldberg; Anders Knutsson; Markku Koskenvuo; Maria Nordin; Tuula Oksanen; Jaana Pentti; Reiner Rugulies; Martin J. Shipley; Archana Singh-Manoux; Andrew Steptoe; Sakari Suominen; Töres Theorell; Jussi Vahtera; Marianna Virtanen; Peter Westerholm; Hugo Westerlund; Marie Zins; Mark Hamer; Joshua A. Bell; Adam G. Tabak; Markus Jokela

Summary Background Although overweight and obesity have been studied in relation to individual cardiometabolic diseases, their association with risk of cardiometabolic multimorbidity is poorly understood. Here we aimed to establish the risk of incident cardiometabolic multimorbidity (ie, at least two from: type 2 diabetes, coronary heart disease, and stroke) in adults who are overweight and obese compared with those who are a healthy weight. Methods We pooled individual-participant data for BMI and incident cardiometabolic multimorbidity from 16 prospective cohort studies from the USA and Europe. Participants included in the analyses were 35 years or older and had data available for BMI at baseline and for type 2 diabetes, coronary heart disease, and stroke at baseline and follow-up. We excluded participants with a diagnosis of diabetes, coronary heart disease, or stroke at or before study baseline. According to WHO recommendations, we classified BMI into categories of healthy (20·0–24·9 kg/m2), overweight (25·0–29·9 kg/m2), class I (mild) obesity (30·0–34·9 kg/m2), and class II and III (severe) obesity (≥35·0 kg/m2). We used an inclusive definition of underweight (<20 kg/m2) to achieve sufficient case numbers for analysis. The main outcome was cardiometabolic multimorbidity (ie, developing at least two from: type 2 diabetes, coronary heart disease, and stroke). Incident cardiometabolic multimorbidity was ascertained via resurvey or linkage to electronic medical records (including hospital admissions and death). We analysed data from each cohort separately using logistic regression and then pooled cohort-specific estimates using random-effects meta-analysis. Findings Participants were 120u2008u2008813 adults (mean age 51·4 years, range 35–103; 71u2008445 women) who did not have diabetes, coronary heart disease, or stroke at study baseline (1973–2012). During a mean follow-up of 10·7 years (1995–2014), we identified 1627 cases of multimorbidity. After adjustment for sociodemographic and lifestyle factors, compared with individuals with a healthy weight, the risk of developing cardiometabolic multimorbidity in overweight individuals was twice as high (odds ratio [OR] 2·0, 95% CI 1·7–2·4; p<0·0001), almost five times higher for individuals with class I obesity (4·5, 3·5–5·8; p<0·0001), and almost 15 times higher for individuals with classes II and III obesity combined (14·5, 10·1–21·0; p<0·0001). This association was noted in men and women, young and old, and white and non-white participants, and was not dependent on the method of exposure assessment or outcome ascertainment. In analyses of different combinations of cardiometabolic conditions, odds ratios associated with classes II and III obesity were 2·2 (95% CI 1·9–2·6) for vascular disease only (coronary heart disease or stroke), 12·0 (8·1–17·9) for vascular disease followed by diabetes, 18·6 (16·6–20·9) for diabetes only, and 29·8 (21·7–40·8) for diabetes followed by vascular disease. Interpretation The risk of cardiometabolic multimorbidity increases as BMI increases; from double in overweight people to more than ten times in severely obese people compared with individuals with a healthy BMI. Our findings highlight the need for clinicians to actively screen for diabetes in overweight and obese patients with vascular disease, and pay increased attention to prevention of vascular disease in obese individuals with diabetes. Funding NordForsk, Medical Research Council, Cancer Research UK, Finnish Work Environment Fund, and Academy of Finland.


Archive | 2016

Developing Leadership and Employee Health Through the Arts

Julia Romanowska; Anna Nyberg; Töres Theorell

This book examines the problems that a “laissez faire” attitude from managers can create in the workplace, as well as the ensuing illness such problems may cause among employees. The book offers ne ...


Archive | 2007

SLOSH – Swedish Longitudinal Occupational Survey of Health : A nationally representative psychosocial survey of Swedish working population

Anna Kinsten; Linda Magnusson Hanson; Martin Hyde; Gabriel Oxenstierna; Hugo Westerlund; Töres Theorell


Archive | 2018

Work environment, health and the international development agenda

Martin Hyde; Töres Theorell


Dagens nyheter | 2015

Vi kan vända trenden med ökad psykisk ohälsa

Julia Romanowska; Marianne Döös; Gunnar Karlsson; Gerry Larsson; Anna Nyberg; Walter Osika; Töres Theorell


Archive | 2014

Life-CourseAccumulationofNeighborhoodDisadvantage andAllostaticLoad:EmpiricalIntegrationofThreeSocial DeterminantsofHealthFrameworks

Per Gustafsson; Miguel San Sebastian; Urban Janlert; Töres Theorell; Hugo Westerlund; Anne Hammarström


Work, Stress, and Health 2013: Protecting and Promoting Total Worker Health, Los Angeles, CA, 18 May 2013 | 2013

A Longitudinal Analysis of Confirmatory Factor Structure and Measurement Invariance of the Demand Control Support Model: An evidence from SLOSH

Holendro Singh Chungkham; Hugo Westerlund; Töres Theorell


Socialmedicinsk Tidskrift | 2013

Om ledarskap och de anställdas hälsa

Töres Theorell; Anna Nyberg; Julia Romanowska


Archive | 2013

The IPD-Work Consortium Work-related psychosocial factors and health in subgroups: Individual-participant-data meta-analysis

Mika Kivimäki; Töres Theorell; Reiner Rugulies; Nico Dragano


Archive | 2010

study disease among employees: the Swedish WOLF Managerial leadership and ischaemic heart

Anna Nyberg; Lars Alfredsson; Töres Theorell

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Lars Alfredsson

Karolinska University Hospital

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Mika Kivimäki

University College London

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