Torin K. Clark

Vestibular Perceptual Thresholds Increase above the Age of 40

We measured vestibular perceptual thresholds in 105 healthy humans (54F/51M) ranging from 18 to 80 years of age. Direction-recognition thresholds were measured using standard methods. The motion consisted of single cycles of sinusoidal acceleration at 0.2 Hz for roll tilt and 1.0 Hz for yaw rotation about an earth-vertical axis, inter-aural earth-horizontal translation (y-translation), inferior–superior earth-vertical translation (z-translation), and roll tilt. A large subset of this population (99 of 105) also performed a modified Romberg test of standing balance. Despite the relatively large population (54F/51M), we found no difference between thresholds of male and female subjects. After pooling across sex, we found that thresholds increased above the age of 40 for all five motion directions investigated. The data were best modeled by a two-segment age model that yielded a constant baseline below an age cutoff of about 40 and a threshold increase above the age cutoff. For all subjects who passed all conditions of the balance test, the baseline thresholds were 0.97°/s for yaw rotation, 0.66°/s for 1-Hz roll tilt, 0.35°/s for 0.2-Hz roll tilt, 0.58 cm/s for y-translation, and 1.24 cm/s for z-translation. As a percentage of the baseline, the fitted slopes (indicating the threshold increase each decade above the age cutoff) were 83% for z-translation, 56% for 1-Hz roll tilt, 46% for y-translation, 32% for 0.2-Hz roll tilt, and 15% for yaw rotation. Even taking age and other factors into consideration, we found a significant correlation of balance test failures with increasing roll-tilt thresholds.

Human perceptual overestimation of whole body roll tilt in hypergravity

Hypergravity provides a unique environment to study human perception of orientation. We utilized a long-radius centrifuge to study perception of both static and dynamic whole body roll tilt in hypergravity, across a range of angles, frequencies, and net gravito-inertial levels (referred to as G levels). While studies of static tilt perception in hypergravity have been published, this is the first to measure dynamic tilt perception (i.e., with time-varying canal stimulation) in hypergravity using a continuous matching task. In complete darkness, subjects reported their orientation perception using a haptic task, whereby they attempted to align a hand-held bar with their perceived horizontal. Static roll tilt was overestimated in hypergravity, with more overestimation at larger angles and higher G levels, across the conditions tested (overestimated by ∼35% per additional G level, P < 0.001). As our primary contribution, we show that dynamic roll tilt was also consistently overestimated in hypergravity (P < 0.001) at all angles and frequencies tested, again with more overestimation at higher G levels. The overestimation was similar to that for static tilts at low angular velocities but decreased at higher angular velocities (P = 0.006), consistent with semicircular canal sensory integration. To match our findings, we propose a modification to a previous Observer-type canal-otolith interaction model. Specifically, our data were better modeled by including the hypothesis that the central nervous system treats otolith stimulation in the utricular plane differently than stimulation out of the utricular plane. This modified model was able to simulate quantitatively both the static and the dynamic roll tilt overestimation in hypergravity measured experimentally.

Modeling human perception of orientation in altered gravity.

Altered gravity environments, such as those experienced by astronauts, impact spatial orientation perception, and can lead to spatial disorientation and sensorimotor impairment. To more fully understand and quantify the impact of altered gravity on orientation perception, several mathematical models have been proposed. The utricular shear, tangent, and the idiotropic vector models aim to predict static perception of tilt in hyper-gravity. Predictions from these prior models are compared to the available data, but are found to systematically err from the perceptions experimentally observed. Alternatively, we propose a modified utricular shear model for static tilt perception in hyper-gravity. Previous dynamic models of vestibular function and orientation perception are limited to 1 G. Specifically, they fail to predict the characteristic overestimation of roll tilt observed in hyper-gravity environments. To address this, we have proposed a modification to a previous observer-type canal-otolith interaction model based upon the hypothesis that the central nervous system (CNS) treats otolith stimulation in the utricular plane differently than stimulation out of the utricular plane. Here we evaluate our modified utricular shear and modified observer models in four altered gravity motion paradigms: (a) static roll tilt in hyper-gravity, (b) static pitch tilt in hyper-gravity, (c) static roll tilt in hypo-gravity, and (d) static pitch tilt in hypo-gravity. The modified models match available data in each of the conditions considered. Our static modified utricular shear model and dynamic modified observer model may be used to help quantitatively predict astronaut perception of orientation in altered gravity environments.

Analysis of human spatial perception during lunar landing

Crewed lunar landings require astronauts to interact with automated systems to identify a location that is level and free of hazards and to guide the vehicle to the lunar surface through a controlled descent. However, vestibular limitations resulting from exposure to lunar gravity after short-term adaptation to weightlessness, combined with acceleration profiles unique to lunar landing trajectories may result in astronaut spatial disorientation. A quantitative mathematical model of human spatial orientation previously developed was adopted to analyze disorientation concerns during lunar landing conditions that cannot be reproduced experimentally. Vehicle acceleration and rotation rate profiles of lunar landing descent trajectories were compiled and entered as inputs to the orientation model to predict astronaut perceived orientations. Both fully automated trajectories and trajectories with pilot interaction were studied. The latter included both simulated landing point redesignation and direct manual control. The lunar descent trajectories contain acceleration and rotation rate profiles producing attitude perceptions that differ substantially from the actual vehicle state. In particular, a somatogravic illusion is predicted that causes the perceived orientation to be nearly upright compared to the actual vehicle state which is pitched back. Furthermore, astronaut head location within the vehicle is considered for different vehicle designs to determine the effect on perceived orientation. The effect was found to be small, but measureable (0.3-4.1 degrees), and larger for the new Altair vehicle design compared to the Apollo Lunar Module.

Dynamics of Individual Perceptual Decisions

Perceptual decision making is fundamental to a broad range of fields including neurophysiology, economics, medicine, advertising, law, etc. Although recent findings have yielded major advances in our understanding of perceptual decision making, decision making as a function of time and frequency (i.e., decision-making dynamics) is not well understood. To limit the review length, we focus most of this review on human findings. Animal findings, which are extensively reviewed elsewhere, are included when beneficial or necessary. We attempt to put these various findings and data sets, which can appear to be unrelated in the absence of a formal dynamic analysis, into context using published models. Specifically, by adding appropriate dynamic mechanisms (e.g., high-pass filters) to existing models, it appears that a number of otherwise seemingly disparate findings from the literature might be explained. One hypothesis that arises through this dynamic analysis is that decision making includes phasic (high pass) neural mechanisms, an evidence accumulator and/or some sort of midtrial decision-making mechanism (e.g., peak detector and/or decision boundary).

Multivariate Analyses of Balance Test Performance, Vestibular Thresholds, and Age

We previously published vestibular perceptual thresholds and performance in the Modified Romberg Test of Standing Balance in 105 healthy humans ranging from ages 18 to 80 (1). Self-motion thresholds in the dark included roll tilt about an earth-horizontal axis at 0.2 and 1 Hz, yaw rotation about an earth-vertical axis at 1 Hz, y-translation (interaural/lateral) at 1 Hz, and z-translation (vertical) at 1 Hz. In this study, we focus on multiple variable analyses not reported in the earlier study. Specifically, we investigate correlations (1) among the five thresholds measured and (2) between thresholds, age, and the chance of failing condition 4 of the balance test, which increases vestibular reliance by having subjects stand on foam with eyes closed. We found moderate correlations (0.30–0.51) between vestibular thresholds for different motions, both before and after using our published aging regression to remove age effects. We found that lower or higher thresholds across all threshold measures are an individual trait that account for about 60% of the variation in the population. This can be further distributed into two components with about 20% of the variation explained by aging and 40% of variation explained by a single principal component that includes similar contributions from all threshold measures. When only roll tilt 0.2 Hz thresholds and age were analyzed together, we found that the chance of failing condition 4 depends significantly on both (p = 0.006 and p = 0.013, respectively). An analysis incorporating more variables found that the chance of failing condition 4 depended significantly only on roll tilt 0.2 Hz thresholds (p = 0.046) and not age (p = 0.10), sex nor any of the other four threshold measures, suggesting that some of the age effect might be captured by the fact that vestibular thresholds increase with age. For example, at 60 years of age, the chance of failing is roughly 5% for the lowest roll tilt thresholds in our population, but this increases to 80% for the highest roll tilt thresholds. These findings demonstrate the importance of roll tilt vestibular cues for balance, even in individuals reporting no vestibular symptoms and with no evidence of vestibular dysfunction.

Flow Visualization for Pulsatile Vortex Ring Actuators

Formation and evolution of vortex rings produced from pulsatile vortex ring thrusters are studied using flow visualization techniques. A vortex ring thruster consists of a cavity with an orifice at one end and an oscillating plunger at the opposite end which periodically creates a volume change in the cavity forcing a jet emission of fluid through the orifice into the surrounding reservoir. The ratio of the cylindrical jet length to its diameter, known as the stroke ratio, is a primary factor in the vortex ring formation characteristics. Flow visualization is employed in order to measure the translational velocity of the leading vortex ring for the range of stroke ratios of 2.96–5.92. The velocity time history of the vortex rings is studied with the results comparing well with theoretical approximations. Additionally vortex ring dimensions, including semimajor axis, semiminor axis, the ratio of these dimensions, and core to core radius, are considered. Also the volume of the vortex ring atmosphere is studied. The variations of these parameters with respect to stroke ratio, time, and distance from the orifice are investigated.Copyright

Development of a countermeasure to enhance sensorimotor adaptation to altered gravity levels

Astronauts experience several gravitational transitions during their journey into space, and they must adapt their sensorimotor capabilities to perform their tasks safely and successfully. A decrement in orientation perception ability or motor skills during a critical mission phase such as landing or docking may lead to catastrophic consequences. The overall objective of this research effort is to investigate and quantify sensorimotor adaptation to altered gravity levels using a short-radius centrifuge. Individual differences, the effect of pre-training in a different gravity environment, and the effect of promethazine in reducing sensorimotor impairment and space motion sickness are of particular interest. The hypotheses are: (1) individual differences exist in the ability to adapt to altered gravity environments and these differences can be predicted for hypo-gravity by measuring adaptability in a hyper-gravity environment, (2) training in one altered gravity environment will improve sensorimotor adaptation in another altered gravity environment, and (3) promethazine will reduce motion sickness, but will have no influence on either basic vestibular perceptual function or sensorimotor adaptation. We are using two tasks to characterize performance decrements and subsequent adaptation that reduces errors: orientation perception and manual control. A series of experiments utilizing these tasks are being conducted on our short-radius centrifuge. For the perception task, subjects report their orientation during a series of roll tilts, while for manual control task, subjects attempt to null a pseudo-random roll tilt disturbance to keep themselves upright using a joystick. We describe preliminary results showing an initial disruption in ability to do both tasks in an altered gravity environment, followed by a learning process to reduce errors. We also tested whether promethazine impacts basic vestibular function by conducting a double-blind, within-subject study with 10 subjects, in which we compared vestibular perceptual thresholds measured with the administration of promethazine or a placebo. Results indicate that promethazine has little effect on perceptual thresholds. Since perceptual measurements can have some inherent measurement variability, we combined subject testing with Monte Carlo simulation tools we developed to evaluate how precisely adaptation rate can be measured. This approach allowed us to optimize experimental design to ensure that precise measures of adaptation rate will be determined. Experimental results show that subjects can, on average, report tilt with a precision of 2°. Simulations show that this corresponds to a coefficient of variation on adaptation time constant of around 20%.

Human Spatial Orientation Perception During Simulated Lunar Landing Motions

Safe and precise piloted lunar landings require control inputs that depend on an accurate perception of vehicle orientation and motion. However, the unique environment and motions experienced during a lunar landing trajectory may lead to misperceptions in vehicle state. Eight subjects participated in a human subject experiment in the NASA Ames vertical motion simulator, where self-reports of perceptions of vehicle tilt angle and horizontal velocity were made during lunar-landing-like motions. Three cases of sensory cues were studied: Subjects were blindfolded and given no visual cues; subjects were provided a simulated dynamic view of the lunar terrain out a forward-looking window; and subjects were provided dynamic instrument displays showing current vehicle states. Subjects’ perception indications differed substantially from the motions being simulated in the blindfolded and out-the-window conditions, but were better matched when viewing instrument displays. Subject perceptions were also compared with p...

Balance Screening of Vestibular Function in Subjects Aged 4 Years and Older: A Living Laboratory Experience.

To better understand the various individual factors that contribute to balance and the relation to fall risk, we performed the modified Romberg Test of Standing Balance on Firm and Compliant Support, with 1,174 participants between 4 and 83 years of age. This research was conducted in the Living Laboratory® at the Museum of Science, Boston. We specifically focus on balance test condition 4, in which individuals stand on memory foam with eyes closed, and must rely on their vestibular system; therefore, performance in this balance test condition provides a proxy for vestibular function. We looked for balance variations associated with sex, race/ethnicity, health factors, and age. We found that balance test performance was stable between 10 and 39 years of age, with a slight increase in the failure rate for participants 4–9 years of age, suggesting a period of balance development in younger children. For participants 40 years and older, the balance test failure rate increased progressively with age. Diabetes and obesity are the two main health factors we found associated with poor balance, with test condition 4 failure rates of 57 and 19%, respectively. An increase in the odds of having fallen in the last year was associated with a decrease in the time to failure; once individuals dropped below a time to failure of 10 s, there was a significant 5.5-fold increase in the odds of having fallen in the last 12 months. These data alert us to screen for poor vestibular function in individuals 40 years and older or suffering from diabetes, in order to undertake the necessary diagnostic and rehabilitation measures, with a focus on reducing the morbidity and mortality of falls.