Toru Yanagisawa

Functional anatomy of GO/NO-GO discrimination and response selection — a PET study in man

The purpose of this study was to identify the functional fields activated in relation to the NO-GO decision. Nine healthy subjects participated in the study which consisted of two test positron emission tomography (PET) scans (GO/NO-GO task and response selection task) and one control scan. In the response selection task, subjects were asked to flex their thumb of the right hand when a light emitting diode (LED) placed 60 cm from their eyes turned on red and to flex their index finger of the right hand when LED turned on green. In the GO/NO-GO task, subjects were asked to flex their thumb when the LED turned on red, however, they were asked not to move their fingers when LED turned on green. In the control state, they were asked simply to look at the LED without any movement of finger during the course of the scan. The mean regional cerebral blood flow (rCBF) change images for each task minus control and task minus task were calculated and fields of significant rCBF changes were identified. Several fields in the prefrontal cortex of the right hemisphere were specifically activated in relation to the GO/NO-GO task. The results indicate that the prefrontal cortex of the right hemisphere may be a key structure to make a decision not to move.

Changes in rCBF during grasping in humans examined by PET

To identify the functional fields involved in grasping for objects, we measured regional cerebral blood flow (rCBF) by positron emission tomography (PET) in eight normal volunteers. In the reaching and grasping tasks, the subjects were asked to touch or grasp one of five cylinders with their right finger(s). Compared with reaching, grasping specifically increased the rCBF in the fields located in the bilateral premotor area (PMA), the posterior parietal area (PPA) and the prefrontal area (PFA). These results indicate that PMA, PPA and PFA might be key structures for the performance of grasping movements.

Changes in regional cerebral blood flow during self-paced arm and finger movements. A PET study

The purpose of this study was to identify the functional fields activated in relation to the self-paced proximal and distal arm movements. The regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) and 15O-labelled H2O (H2(15)O) in eight healthy subjects. All subjects performed the following three tasks: (1) repetitive opposition of thumb and index finger of the right hand, (2) repetitive co-contraction of biceps and tricepts brachii muscles of the right arm, and (3) rest. The mean rCBF change images for each task minus control was calculated and fields of significant rCBF changes were identified. Each movement activated different fields in the primary motor area (MI), the dorsal aspect of the premotor area (PMA) and the superior part of the prefrontal area (PFA) of the contralateral hemisphere. In these areas, arm fields were located relatively dorsally to the finger fields. In addition, specific fields in the ventral part of the PMA, the supplementary motor area (SMA), the superior parietal lobule (SPL) of the contralateral hemisphere, and the ipsilateral PFA were consistently activated during both movements. Due to a limited a field of view of the PET scanner in the axial direction, the PET scan could not cover the cerebellum. The results indicate that there may be somatotopical organization not only in the MI but also in the dorsal part of the PMA and the PFA, and that the specific fields in the ventral part of the PMA, the SMA, the SPL, and the PFA may be involved in self-paced movement.

Repetitive flash x‐ray generator utilizing a simple diode with a new type of energy‐selective function

The construction and the fundamental studies of a repetitive flash x‐ray generator having a simple diode with an energy‐selective function are described. This generator consisted of the following components: a constant high‐voltage power supply, a high‐voltage pulser, a repetitive high‐energy impulse switching system, a turbo molecular pump, and a flash x‐ray tube. The circuit of this pulser employed a modified two‐stage surge Marx generator with a capacity during main discharge of 425pF. The x‐ray tube was of the demountable‐diode type which was connected to the turbo molecular pump and consisted of the following major devices: a rod‐shaped anode tip made of tungsten, a disk cathode made of graphite, an aluminum filter, and a tube body made of glass. Two condensers inside of the pulser were charged from 40 to 60 kV, and the output voltage was about 1.9 times the charging voltage. The peak tube voltage was primarily determined by the anode‐cathode (A‐C) space, and the peak tube current was less than 0.6 k...

Repetitive flash x‐ray generator having a high‐durability diode driven by a two‐cable‐type line pulser

The fundamental studies of a repetitive soft flash x‐ray generator having a high‐durability diode for high‐speed radiography in biomedical and technological fields are described. This generator consisted of the following essential components: a constant negative high‐voltage power supply, a line‐type high‐voltage pulser with two 10 m coaxial‐cable condensers, each with a capacity of 1.0 nF, a thyratron pulser as a trigger device, an oil‐diffusion pump, and a flash x‐ray tube. The x‐ray tube was of a diode type which was evacuated by an oil‐diffusion pump with a pressure of approximately 6.7×10−3 Pa and was composed of a planar tungsten anode, a planar ferrite cathode, and a polymethylmethacrylate tube body. The space between the anode and cathode electrodes (AC space) could be regulated from the outside of the tube. The two cable condensers were charged from −40 to −60 kV by a power supply, and the output voltage was about −1.5 times the charged voltage. Both the first peak voltage and current increased a...

Fundamental Study on a Long-Duration Flash X-Ray Generator with a Surface-Discharge Triode

Fundamental studies on a long-duration flash X-ray generator are described. This generator consisted of the following components: a high-voltage power supply with a maximum voltage of 100 kV, an energy-storage condenser of 500 nF, a main discharge condenser of 10 nF, a turbo molecular pump, a thyratron pulser as a trigger device, and a surface-discharge triode. The effective pulse width was less than 30 µs, and the X-ray intensity approximately had a value of 0.6 µC/kg at 1.0 m per pulse with a charged voltage of 60 kV. The maximum tube voltage was equivalent to the initial charged voltage of the condenser, and the peak tube current was less than 40 A. With this generator, we could obtain stable X-ray intensity maximized by preventing damped oscillations of the tube voltage and current.

Activity in the human primary motor cortex related to arm and finger movements.

With the purpose of mapping representations of the finger and proximal arm in the human primary motor cortex (MI), we measured regional cerebral blood flow (rCBF) in eight right-handed normal volunteers during self-paced finger and proximal arm movements. Each movement activated two different fields in MI, one located deep in the anterior lip of the central sulcus and the other relatively close to the surface of the precentral gyrus. Arm fields were located higher than finger fields. A superficial arm field and a deep finger field partially, overlapped. The results indicate that there are two spatially separate motor representations of the finger and proximal arm in the human MI.

Computer-aided diagnosis in chest radiography. Preliminary experience.

RATIONALE AND OBJECTIVES.Computer-aided diagnosis (CAD) schemes for chest radiography are being developed with which to alert radiologists to possible lesions, and thus potentially improve diagnostic accuracy. However, CAD schemes have not been tested on a large number of clinical cases. The authors identify design parameters that would be required for development of an intelligent workstation. METHODS.Computer-aided diagnosis programs were applied for the automated detection of lung nodules, cardiomegaly, and interstitial infiltrates to 310 consecutive chest radiographs, and were analyzed for potential usefulness and limitations. Computer-aided diagnosis output was evaluated by radiologists and physicists for accuracy and technical problems, respectively. RESULTS.Approximately 70% of the results were judged to be potentially acceptable; however, the number of false-positive findings was relatively high. Technical problems included failure to detect subtle abnormalities and the occurrence of false-positive detections caused by normal anatomical structures. CONCLUSION.Computer-aided diagnosis has the potential to be a valuable aid to radiologists in clinical practice, if certain technical problems can be overcome and if optimal operating points can be defined for clinical use.

Sub-kilohertz flash X-ray generator utilising a glass-enclosed cold-cathode triode.

The construction and fundamental studies are described for a subkilohertz X-ray generator for producing low-dose rate flash X-rays. The X-ray tube was a glass-enclosed cold-cathode triode, composed of a tungsten plate target, a rod-shaped graphite cathode, a mesh-type trigger electrode made of tungsten wires, and a glass tube body. The coaxial condenser was charged up to 60 kV by a power supply, and the electric charges in the condenser were discharged to the X-ray tube repetitively when a negative high-voltage pulse was applied to the trigger electrode. The maximum tube voltage before the discharging was equivalent to the initial charged voltage of the condenser, and the maximum tube current was about 0.3 kA with a charged voltage of 60 kV. The X-ray durations were about 1 μs, and the X-ray intensity was about 0.47 μC kg−1 at 0.5 m per pulse with a charged voltage of 60 kV. The maximum repetition rate of the X-rays was about 0.4 kHz, and high-speed radiography was performed.

Kilohertz‐range flash x‐ray generator utilizing a triode in conjunction with an extremely hot cathode

The construction and the fundamental studies of a kilohertz‐range flash x‐ray generator having a triode in conjunction with an extremely hot cathode are described. This generator consisted of the following components: a constant‐high voltage power supply, an energy storage condenser of 100 nF, a constant high‐voltage power supply for regulating an initial grid voltage of −1.6 kV, a grid pulser, and an x‐ray tube. The x‐ray tube was of an enclosed‐triode type and consisted of the following major parts: an anode rod made of copper, a plane anode tip (target) made of tungsten, a focusing electrode made of iron, a hot cathode (filament) made of tungsten, a grid made from tungsten wire, and a glass tube body. The energy storage condenser was charged from 50 to 70 kV, and the electric charges in the condenser were discharged repetitively to the x‐ray tube by the grid electrode driven by the grid pulser. The temperature of the filament was about 2000 K, and the cathode current was primarily controlled by the gri...