Toshiaki Tomimatsu

Seven aromatic compounds from bark of Cinnamomum cassia

Abstract Seven aromatic compounds have been obtained from the dried bark of Cinnamomum cassia : lyoniresinol 3α- O -β- D -glucopyranoside, 3,4,5-trimethoxyphenol β- D -apiofuranosyl-(1 → 6)-β- D -glucopyranoside, (±)-syringaresinol, two epicatechin derivatives and two cinnamic aldehyde cyclic glycerol 1,3-acetals.

Glycosides of ergosterol derivatives from Hericum erinacens

Abstract A new glycoside of ergosta-7,22-diene-3,5,6-triol was isolated from the dry fruiting body of Hericum erinacens and the structure was established by chemical and spectroscopic means. Six ergosterol derivatives were also isolated from H. erinacens .

Four kaempferol glycosides from leaves of Cinnamomum sieboldii

Abstract Four flavonol glycosides were isolated from Cinnamomum sieboldii and characterized as kaempferol 7- O -α- l -rhamnopyranosides having 3- O -α- l -rhamnopyranosyl, 3- O -α- l -arabinofuranosyl, 3- O -β- d - apiofuranosyl-(1→2)-α- l -arabinofuranosyl and 3- O -β- d -glucopyranosyl-(1→ 3)-α- l -rhamnopyranosyl residues, respectively. The latter three are new compounds.

Two steroidal glycosides, aculeatiside A and B from Solanum aculeatissimum☆

Abstract Two new steroidal glycosides, named aculeatiside A and B, were isolated in yields of ca 0.1 and 3.0%, respectively, from the root of Solanum aculeatissimum and their structures were determined as 26- O -β- D -glucopyranosyl nuatigenin 3- O -β-chacotrioside and 26- O -β- D -glucopyranosyl nuatigenin 3- O -β-solatrioside respectively. Therefore, this plant is considered to be a useful source of pregnane derivatives.

12-Hydroxy steroidal glycosides from the caudex of Yucca gloriosa

Eight new steroidal glycosides, tentatively named YS-VI, -VII, -VIII, -IX, -X, -XI, -XII and -XIII were isolated from the caudex of Yucca gloriosa along with P-1, YG-2 and YG-3 previously obtained from flowers. The structures of five of these compounds were elucidated as mexogenin 3-O-beta-D-glucopyranosyl-(1----2)-beta-D-galactopyranoside (YS-VI), gloriogenin 3-O-beta-D-glucopyranosyl-(1----2)-[beta- D-glucopyranosyl-(1----3)]-beta-D-glucopyranoside (YS-VII) and 3-O-beta-D-glucopyranosyl-(1----2)-[beta-D-glucopyranosyl)-(1----3)]- beta-D-galactopyranoside (YS-VIII), manogenin 3-O-beta-lycotetraoside (YS-IX) and 3-O-alpha-L-rhamnopyranosyl-beta-lycotetraoside (YS-X), respectively, on the basis of chemical and spectral evidence.

The steroidal glycosides of the flowers of Yucca gloriosa

Abstract Four steroidal compounds were isolated from the fresh flowers of Yucca gloriosa and their structures were elucidated as tigogenin 3-O-β- d -xylopyranosyl-β-lycotetraoside, gitogenin 3-O-β- d -xylopyranosyl-β-lycotetraoside, gitogenin 3-O-α- l -rhamnopyranosyl-β-lycotetraoside and proto-type of gitogenin 3-O-β- d -xylopyranosyl-β-lycotetraoside, on the basis of physical and chemical investigations.

Structures of sesquiterpene polyol esters from Tripterygium wilfordii var. Regelii

Abstract Seven new dihydroagarofuran derivatives, triptogelin E-1, E-2, E-3, E-4, G-1, C-4 and D-1 have been isolated from T. wilfordii var. regelii. Their structures have been established on the basis of spectroscopic and chemical evidence.

A polyoxygenated steroid fromLasiosphaera nipponica

Abstract A new polyoxygenated ergosterol derivative, as well as three known steroids and a calvatic acid derivative were isolated fromLasiosphaera nipponica. The structures of these compounds were established by chemical and spectroscopic means.

Two aromatic compounds related to brazilin from Caesalpinia sappan

Abstract Two new aromatic compounds structurally related to brazilin were isolated and identified from the heartwood of Caesalpinia sappan . They possessed antihypercholesteremic activity.

Sesquiterpene esters from Tripterygium wilfordii

Abstract New sesquiterpene esters, triptogelin A-5, A-6, A-7, A-8 and A-9 have been isolated from the achenes of Tripterygium wilfordii Hook fil. var. regelii and their structures have been established on the basis of spectroscopic and chemical evidence. The structural elucidation of triptogelin A-6, was confused by ester rearrangement which occurred during partial hydrolysis, but the structure was eventually determined by using 2D NMR spectrum.