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Toshifumi Hasegawa

Bristol-Myers Squibb

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Publication

Featured researches published by Toshifumi Hasegawa.

The Journal of Antibiotics | 1993

Biosynthesis of the pradimicin family of antibiotics. III: Biosynthetic pathway of both pradimicins and benanomicins

Shizuko Kakinuma; Kiyoshi Suzuki; Masami Hatori; Kyoichiro Saitoh; Toshifumi Hasegawa; Tamotsu Furumai; Toshikazu Oki

The Journal of Antibiotics | 1993

Biosynthesis of the pradimicin family of antibiotics. II. Fermentation, isolation and structure determination of metabolites associated with the pradimicins biosynthesis.

Takashi Tsuno; Haruaki Yamamoto; Yukio Narita; Kiyoshi Suzuki; Toshifumi Hasegawa; Shizuko Kakinuma; Kyoichiro Saitoh; Tamotsu Furumai; Toshikazu Oki

The Journal of Antibiotics | 1993

Synthesis and antifungal activity of pradimicin derivatives. Modifications on the aglycone part.

Shimpei Aburaki; Satsuki Okuyama; Hideaki Hoshi; Hajime Kamachi; Maki Nishio; Toshifumi Hasegawa; Shinji Masuyoshi; Seiji Iimura; Masataka Konishi; Toshikazu Oki

The Journal of Antibiotics | 1993

A new neuritogenetic compound BU-4514N produced by Microtetraspora sp.

Soichiro Toda; Satoshi Yamamoto; Osamu Tenmyo; Takashi Tsuno; Toshifumi Hasegawa; Mary P. Rosser; Masahisa Oka; Yosuke Sawada; Masataka Konishi; Toshikazu Oki

The Journal of Antibiotics | 1993

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE CHAIN

Takaaki Okita; Kiyoto Imae; Toshifumi Hasegawa; Seiji Iimura; Shinji Masuyoshi; Hajime Kamachi; Hideo Kamei

The Journal of Antibiotics | 1993

Pradimicins T1 and T2, new antifungal antibiotics produced by an actinomycete. II: Structures and biosynthesis

Toshifumi Hasegawa; Masatoshi Kakushima; Masami Hatori; Shimpei Aburaki; Shizuko Kakinuma; Tamotsu Furumai; Toshikazu Oki

The Journal of Antibiotics | 1993

Pradimicins T1 and T2, new antifungal antibiotics produced by an actinomycete. I: Taxonomy, production, isolation, physico-chemical and biological properties

Tamotsu Furumai; Toshifumi Hasegawa; Masatoshi Kakushima; Kiyoshi Suzuki; Haruaki Yamamoto; Satoshi Yamamoto; Minoru Hirano; Toshikazu Oki

The Journal of Antibiotics | 1993

Microbial modification of pradimicins at C-11 leading to 11-O-demethyl- and 11-O-L-xylosylpradimicins A and FA-1

Tamotsu Furumai; Haruaki Yamamoto; Yukio Narita; Toshifumi Hasegawa; Shimpei Aburaki; Masatoshi Kakushima; Toshikazu Oki

The Journal of Antibiotics | 1993

Cephalosporins having a heterocyclic catechol in the C3 side chain. I. Enhancement of efficacy against gram-negative bacteria.

Kiyoto Imae; Seiji Iimura; Toshifumi Hasegawa; Takaaki Okita; Minoru Hirano; Hajime Kamachi; Hideo Kamei

The Journal of Antibiotics | 1993

Cephalosporins having a heterocyclic catechol in the C3 side chain. II. Improvement of pharmacokinetic profile.

Seiji Iimura; Kiyoto Imae; Toshifumi Hasegawa; Takaaki Okita; Masami Tamaoka; Shinji Murata; Hajime Kamachi; Hideo Kamei

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Collaboration

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Toshikazu Oki

Tamagawa University

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Kiyoshi Suzuki

Bristol-Myers Squibb

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Tamotsu Furumai

Toyama Prefectural University

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Hajime Kamachi

Bristol-Myers Squibb

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Haruaki Yamamoto

Bristol-Myers Squibb

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Masatoshi Kakushima

Merck

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Seiji Iimura

Bristol-Myers Squibb

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Shizuko Kakinuma

Kitasato University

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Hideo Kamei

Bristol-Myers Squibb

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Kiyoto Imae

Bristol-Myers Squibb

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