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Dive into the research topics where Toshihiko Akiyama is active.

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Featured researches published by Toshihiko Akiyama.


Journal of The Chemical Society-perkin Transactions 1 | 2001

Synthesis of trisphaeridine and norchelerythrine through palladium-catalyzedaryl–aryl coupling reactions

Takashi Harayama; Hisashi Akamatsu; Kana Okamura; Taeko Miyagoe; Toshihiko Akiyama; Hitoshi Abe; Yasuo Takeuchi

Total syntheses of trisphaeridine (3) and norchelerythrine (4), fully aromatized phenanthridine and benzo[c]phenanthridine alkaloids, were accomplished via the internal aryl–aryl coupling reaction of halo amides protected by a methoxymethyl group with the palladium reagent, followed by reduction with lithium aluminium hydride and treatment with hydrochloric acid.


Synthesis | 2001

Total Synthesis of Benzo[c]phenanthridine Alkaloids, Chelerythrine and 12-Methoxydihydrochelerythrine, by a Palladium-Assisted Internal Biaryl Coupling Reaction

Takashi Harayama; Toshihiko Akiyama; Hisashi Akamatsu; Kazuko Kawano; Hitoshi Abe; Yasuo Takeuchi


Chemical & Pharmaceutical Bulletin | 2000

Synthesis of arnottin I through a palladium-mediated aryl-aryl coupling reaction

Takashi Harayama; Hirotake Yasuda; Toshihiko Akiyama; Yasuo Takeuchi; Hitoshi Abe


Chemical & Pharmaceutical Bulletin | 2002

Aryl-aryl coupling reaction using a novel and highly active palladium reagent prepared from Pd(OAc)2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P

Takashi Harayama; Toshihiko Akiyama; Yuichiro Nakano; Hiromi Nishioka; Hitoshi Abe; Yasuo Takeuchi


Synthesis | 2004

Synthesis of benzo[c]phenanthridine alkaloids, using a novel palladium-phosphine combination system - Pd(OAc)2, DPPP, and Bu3P

Takashi Harayama; Toshihiko Akiyama; Yuichiro Nakano; Kentaro Shibaike; Hisashi Akamatsu; Akihiro Hori; Hitoshi Abe; Yasuo Takeuchi


Chemical & Pharmaceutical Bulletin | 1996

A CONVENIENT SYNTHESIS OF BENZO[C]PHENANTHRIDINE ALKALOID, CHELERYTHRINE, BY THE PALLADIUM-ASSISTED INTERNAL BIARYL COUPLING REACTION

Takashi Harayama; Toshihiko Akiyama; Kazuko Kawano


Synthesis | 1999

Facile and General Syntheses of 3- and/or 5-Substituted 7-β-d-Ribofuranosyl-7H-[1,2,4]triazolo[3,4-i]purines as a New Class of Potential Xanthine Oxidase Inhibitors

Tomohisa Nagamatsu; Hiroo Yamasaki; Toshihiko Akiyama; Sachiko Hara; Kenya Mori; Hitoshi Kusakabe


Heterocycles | 1998

Synthesis of Benzo[c]phenanthridine Alkaloids, Chelerythrine and Nitidine, Using a Novel Palladium-Phosphine Combination System - Pd(OAc)2, DPPP, and Bu3P -

Takashi Harayama; Toshihiko Akiyama; Yuichiro Nakano; Kentaro Shibaike


Heterocycles | 2002

Aryl-aryl coupling reaction catalyzed by A palladium reagent prepared from Pd(OAC)2 and n-Bu3P

Takashi Harayama; Akihiro Hori; Yuichiro Nakano; Toshihiko Akiyama; Hitoshi Abe; Yasuo Takeuchi


Chemical & Pharmaceutical Bulletin | 1997

Internal aryl-aryl coupling reaction using a novel and highly active palladium reagent prepared from Pd(OAC)2, DPPP, and Bu3P

Takashi Harayama; Toshihiko Akiyama; Yuichiro Nakano

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Takashi Harayama

Tokushima Bunri University

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