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Dive into the research topics where Toshio Hyogo is active.

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Featured researches published by Toshio Hyogo.


World Neurosurgery | 2011

Determinants of Poor Outcome After Aneurysmal Subarachnoid Hemorrhage when both Clipping and Coiling Are Available: Prospective Registry of Subarachnoid Aneurysms Treatment (PRESAT) in Japan

Waro Taki; Nobuyuki Sakai; Hidenori Suzuki; Akio Hyodo; Shigeru Nemoto; Toshio Hyogo; Tomoaki Terada; K Satoh; Naoya Kuwayama; Shigeru Miyachi; Masaki Komiyama; Masayuki Ezura; Yuichi Murayama; Hiroshi Sakaida; Masayuki Maeda; H Nagai; T Kataoka; S Ishihara; Y Koguchi; S. Kobayashi; Y Enomoto; K Yamada; Shinichi Yoshimura; Yasushi Matsumoto; Masaru Hirohata; H Adachi; Y Ueno; T Kunieda; Chiaki Sakai; H Yamagami

OBJECTIVE To examine current determinants of poor outcome after aneurysmal subarachnoid hemorrhage (SAH) when ruptured aneurysms are treated with either microsurgery (clipping) or endovascular treatment (coiling) depending on each patients characteristics. METHODS Between March 2006 and February 2007, 534 patients with SAH were enrolled in the Prospective Registry of Subarachnoid Aneurysms Treatment (PRESAT) project. Patients were treated according to the preference of investigators who were experienced in performing both clipping and coiling. Factors influencing poor outcome (12-month modified Rankin Scale [mRS], 3-6) were determined using multivariate logistic regression analyses. RESULTS In this cohort, 32.4% of patients were World Federation of Neurosurgical Societies (WFNS) grade IV-V, and 28.1% had a poor outcome. Clipping was preferably performed for small aneurysms with a wide neck and for middle cerebral artery (MCA) aneurysms, whereas coiling was preferred for larger, internal carotid artery (ICA) and posterior circulation aneurysms. In addition to increasing age, admission WFNS grade IV-V, preadmission aneurysmal rerupture, vasospasm-induced cerebral infarct, pneumonia, sepsis, shunt-dependent hydrocephalus and seizure, postclipping hemorrhagic complications (odds ratio 4.8, 95% confidence interval 1.5-15.3, P < 0.01), and postcoiling ischemic complications (odds ratio 4.4, 95% confidence interval 1.3-15.2, P < 0.05) significantly caused poor outcomes, although the complications did not affect mortality. Type of treatment modality and size and location of aneurysms did not influence outcome. CONCLUSIONS Introducing an endovascular treatment option has made aneurysm characteristics less important to outcome, but procedural complications are problematic and should be reduced to improve outcome.


Neuroradiology | 1996

Multiple segmental agenesis of the cerebral arteries: case report

Toshio Hyogo; J. Nakagawara; J. Nakamura; K. Suematsu

A case of multiple segmental agenesis of the cerebral arteries is presented. Cerebral angiography demonstrated bilateral socalled carotid rete mirabile, a similar “rete” of the right vertebral artery and intradural duplication of the left vertebral artery. These abnormalities are thought to be caused by multiple segmental agenesis of the cerebral arteries as they penetrate the dura mater, the embryological and anatomical significance of these findings is discussed.


Journal of Stroke & Cerebrovascular Diseases | 2012

Periprocedural Cilostazol Treatment and Restenosis after Carotid Artery Stenting: The Retrospective Study of In-Stent Restenosis after Carotid Artery Stenting (ReSISteR-CAS)

Hiroshi Yamagami; Nobuyuki Sakai; Yuji Matsumaru; Chiaki Sakai; Yutaka Kai; Kenji Sugiu; Toshiyuki Fujinaka; Yasushi Matsumoto; Shigeru Miyachi; Shinichi Yoshimura; Toshio Hyogo; Naoya Kuwayama; Akio Hyodo

Restenosis after carotid artery stenting (CAS) is a critical issue. Cilostazol can reduce restenosis after interventions in coronary or femoropopliteal arteries. We investigated whether periprocedural cilostazol treatment was related to the incidence of in-stent restenosis (ISR) or target vessel revascularization (TVR) after CAS. The study group comprised 553 of 580 patients who underwent CAS between April 2003 and August 2006 and were followed for 30 months after the procedure. ISR was defined as stenosis of at least 50% detected on angiography or ultrasonography. TVR was defined as revascularization of the treated carotid artery. During CAS, 207 patients (37.4%) were treated with cilostazol. Over 30 months, ISR occurred in 23 patients (4.2%), TVR occurred in 16 patients (2.9%), and either ISR or TVR occurred in 25 patients (4.5%). The incidence of ISR or TVR was significantly lower in the cilostazol-treated group than in the untreated group (1.4% vs 6.4%; log-rank P = .006). In a multivariate analysis, cilostazol treatment (hazard ratio [HR], 0.28; 95% confidence interval [CI], 0.08-0.95; P = .041) and stent diameter (HR, 0.73/1-mm increase; 95% CI, 0.54-0.99; P = .044) were independent factors for the occurrence of ISR or TVR. The incidence of a composite of events, including thromboembolism, hemorrhage, death, and TVR, tended to be lower in the cilostazol-treated group than in the untreated group (15.0% vs 19.9%; log-rank P = .17). Periprocedural cilostazol treatment was associated with lower rates of ISR and retreatment after CAS. A prospective randomized controlled trial is needed to clarify the effect of cilostazol on ISR after CAS.


Neurologia Medico-chirurgica | 2014

Recent trends in neuroendovascular therapy in Japan: analysis of a nationwide survey--Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and 2.

Nobuyuki Sakai; Shinichi Yoshimura; Waro Taki; Akio Hyodo; Shigeru Miyachi; Yoji Nagai; Chiaki Sakai; Tetsu Satow; Tomoaki Terada; Masayuki Ezura; Toshio Hyogo; Shunji Matsubara; Kentaro Hayashi; Toshiyuki Fujinaka; Yasushi Ito; S. Kobayashi; Masaki Komiyama; Naoya Kuwayama; Yuji Matsumaru; Yasushi Matsumoto; Yuichi Murayama; Ichiro Nakahara; Shigeru Nemoto; Koichi Satoh; Kenji Sugiu; Akira Ishii; Hirotoshi Imamura

The present study retrospectively analyzed the database of the Japanese Registry of Neuroendovascular Therapy 1 and 2 (JR-NET1&2) to determine annual trends, including adverse events and clinical outcomes at 30 days after undergoing neuroendovascular therapy. JR-NET1&2 are surveys that targeted all patients in Japan who underwent neuroendovascular therapy delivered by physicians certified by the Japanese Society of Neuroendovascular Therapy (JSNET) between 2005 and 2009. Medical information about the patients was anonymized and retrospectively registered via a website. Data from 32,608 patients were analyzed. The number of treated patients constantly increased from 5,040 in 2005 to 7,406 in 2009 and the rate of octogenarians increased from 7.0% in 2005 to 10.4% in 2009. The proportion of procedures remained relatively constant, but ratios of angioplasty slightly increased from 32.8% in 2005 to 33.7% in 2009. Procedural complications were associated more frequently with acute stroke (9.6%), ruptured aneurysms (7.4%), intracranial artery disease (ICAD) (5.4%), and arteriovenous malformation (AVM, 5.2%). The number of patients requiring neuroendovascular treatment in Japan is increasing and the outcomes of such therapy are clinically acceptable. Details of each type of treatment will be investigated in sub-analyses of the database.


Interventional Neuroradiology | 2008

Japanese society of neuro-endovascular treatment specialist qualification system. Six years' experience and introduction of an animal model examination.

Toshio Hyogo; Waro Taki; M. Negoro; A. Takahashi; M. Edura; A. Hyodo; S. Kobayashi; Masaki Komiyama; N. Kuwayama; Yuji Matsumaru; Shigeru Miyachi; K. Murao; Yuichi Murayama; Ichiro Nakahara; S. Nemoto; Nobuyuki Sakai; Koichi Satoh; Makoto Sonobe; Kenji Sugiu; Tomoaki Terada; S. Yoshimura; T. Abe; Y. Itoh; H. Kiyosue; H. Nagashima; M. Nakamura; S. Matsushima

Recent advances in devices and materials, and therapeutic technical improvements in interventional neuroradiology practice make it possible to use this therapeutic method for the treatment of neurovascular disease. In view of the spread of this treatment and increasing numbers of the procedures, there is a social demand to maintain a certain therapeutic quality. One of the methods used to present the therapeutic quality of doctors to the public is technical and knowledge authorization by an official organization or society. According to the ideas of the Japanese Society of Neuro-Endovascular Therapy (JSNET) “The basic therapeutic standard should be secured by the Society to avoid unnecessary complications which are caused by improper techniques and immature experiences.” JSNET start to develop a Specialist Qualification System in 1997, and the first examination was held in 2002. Details of the development of the system and the requirement of specialists have previously been reported1. It has been ten years since development of this system and we have had eight examinations since 2002. Following six years of experience and two years of examinations using an animal model, we would like to introduce the JSNET Specialist Qualification System.


Interventional Neuroradiology | 2006

Diagnosis of Vertebral Artery Dissection by Basi-parallel Anatomical Scanning (BPAS) MRI.

H. Takada; Toshio Hyogo; T. Kataoka; K. Hayase; H. Nakamura

To diagnose VA dissection, MRA or cerebral angiography, which provides information regarding intra-vascular space, has been performed. We report the acquisition of various information about VA dissection using MRI-BPAS, which is a new diagnostic method.


Journal of Stroke & Cerebrovascular Diseases | 2014

Relationship Between Magnetic Resonance Angiography–Diffusion-weighted Imaging Mismatch and Clinical Outcome in Endovascular Treatment for Acute Ischemic Stroke: Subgroup Analysis of the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism–Japan Registry

Ichiro Deguchi; Tomohisa Dembo; Shinichi Yoshimura; Nobuyuki Sakai; Yasushi Okada; Kazuo Kitagawa; Kazumi Kimura; Toshio Hyogo; Hiroshi Yamagami; Yusuke Egashira; Norio Tanahashi

BACKGROUND The presence or absence of the penumbra area is important when performing reperfusion therapy in patients with acute ischemic stroke. As a predictor of this penumbra area, magnetic resonance angiography (MRA)-diffusion-weighted imaging (DWI) mismatch is attracting attention. The usefulness of MRA-DWI mismatch (MDM) using the DWI-Alberta Stroke Program Early Computed Tomography Score (ASPECTS) in endovascular treatment (EVT) of patients with cerebral large vessel occlusion was evaluated. METHODS Of 1442 patients registered in the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism-Japan Registry between July 1, 2010 and June 30, 2011 who presented to the hospital within 24 hours of the onset of acute cerebral infarction because of cerebral large vessel occlusion, 188 patients who had internal carotid artery or middle cerebral artery occlusion and achieved recanalization with EVT were included. Of these, 71 patients underwent intracranial EVT because intravenous recombinant tissue plasminogen activator therapy was ineffective. The associations between the presence or absence of MDM (MDM-positive [MDM-P], DWI-ASPECTS≥6; MDM-negative [MDM-N], DWI-ASPECTS<6) and 90-day prognosis (modified Rankin Scale [mRS]) and symptomatic intracranial hemorrhage (sICH) were examined. RESULTS Of the 188 patients analyzed, the time from symptom onset to admission was within 3 hours in 143 patients, 3-8 hours in 36 patients, and 8 hours or more in 9 patients. The time from the onset was within 3 hours in 118 patients in the MDM-P and 25 patients in the MDM-N cases. Favorable outcomes (mRS score≤2 at 90 days) were seen in 63 patients (53.4%) in the MDM-P group and 7 patients (28.0%) in the MDM-N group, showing a significantly more favorable clinical outcome in the MDM-P group (P=.027). The incidence of sICH was significantly lower in the MDM-P group (MDM-P group 3.4%, MDM-P group 20.0%; P=.009). The time from the onset was 3-8 hours in 29 patients in the MDM-P group and in 7 patients in the MDM-N group. Favorable outcomes were seen in 12 patients (41.4%) in the MDM-P group and 2 patients (28.6%) in the MDM-N group, with no significant difference between the 2 groups. No patients had sICH. The patients admitted 8 hours or more after the onset were all MDM-P. Five patients (55.6%) had a favorable outcome. CONCLUSIONS This study demonstrated the safety and efficacy of EVT in MDM-P patients within 3 hours of symptom onset. Although the ratio of patients who had a favorable outcome was high in the MDM-P patients admitted 3-8 hours after the onset, the difference was not significant.


Interventional Neuroradiology | 2002

The First Specialist Qualification Examination of the Japanese Society of Intravascular Neurosurgery (JSIN)

Waro Taki; K. Gotoh; A. Hyodo; Toshio Hyogo; K. Kinugasa; T. Koike; Y. Konishi; M. Negoro; S. Nemoto; K. Niimi; Koichi Satoh; Makoto Sonobe; A. Takahashi; Tomoaki Terada

In the past 25 years, interventional neuroradiology (IVNR) has widened its application not only to cerebrovascular diseases but also to vertebroplasty and tumor embolization. Gradually the positive evidence of its usefulness has accumulated in many diseases, and along with the progress of IVNR, the membership of the JSIN rapidly increased. Members now number 1431 (5/24/2002) and include 1200 (83.9%) neurosurgeons, 96 (6.7%) radiologists (neuroradiologist), 31 (2.2%) physicians, eight (0.6%) emergency doctors and 96 (6.6%) others. IVNR requires a great deal of knowledge, techniques and experience to do with the important but vulnerable central nervous system. The basic therapeutic level should be secured by the Society to avoid unnecessary complications which are caused by improper techniques and immature experiences. Hence, there arose the expectation to provide a proper educational system and a rigid selection system for the specialist in JSIN.


Interventional Neuroradiology | 2006

Cerebral Blood Flow Change Before and After Carotid Angioplasty and Stenting (CAS) in Cases with Contralateral Carotid Artery Occlusion.

T. Kataoka; Toshio Hyogo; K. Hayase; H. Nakamura

Contralateral carotid artery occlusion is thought to represent a significant risk factor in carotid endarterectomy (CEA). There is also evidence that intraoperative and postoperative hypotention may cause contralateral hemodynamic ischemia. As such, contralateral carotid artery occlusion is regarded as a risk factor for carotid angioplasty and stenting (CAS). In this paper, we report on five cases of severe ICA stenosis with contralateral carotid artery occlusions. Cerebral blood flow(CBF) and cerebral vasore-activity(CVR) of the contralateral carotid artery occlusions were measured before and after CAS. Additionally, the influence that ipsilateral CAS exerted on the occluded side was examined. 123I-IMP SPECT was performed before and after CAS, both at rest and at the time of acetazoramide administration. The CBF was evaluated quantitatively using the ARG method. The mean CBF of the treated side rose from 30.0 ± 7.1 ml/100g/min to 34.4 ± 8.3 ml/100g/min (p<0.05), and the mean CBF of the occluded side similarly rose from 28.3 ± 6.1 ml/100g/min to 31.7 ± 6.4 ml/100g/min (p<0.05). Correspondingly, the regional CVR (rCVR) increased from 5.9% ± 16.3% to 35.0% ± 16.4%(p<0.05) on the treated side, and from 3.7% ± 14.7% to 10.7% ± 16.9% (p<0.05) on the occluded side. This demonstrates that ipsilateral CAS seems to improve both CBF and CVR on the contralateral occluded side. The fact that some cases developed cross flow from the anterior communicating artery was both remarkable and significant. Where there was poor cross flow from the anterior communicating artery, improvement in cerebral vaso reactivity was limited.


Journal of Stroke & Cerebrovascular Diseases | 2013

Stroke outcomes of Japanese patients with major cerebral artery occlusion in the post-alteplase, pre-MERCI era.

Kaoru Endo; Masatoshi Koga; Nobuyuki Sakai; Hiroshi Yamagami; Eisuke Furui; Yasushi Matsumoto; Yoshiaki Shiokawa; Shinichi Yoshimura; Yasushi Okada; Jyoji Nakagawara; Toshio Hyogo; Yasuhiro Hasegawa; Hisashi Nagashima; Toshiyuki Fujinaka; Akio Hyodo; Tomoaki Terada; Kazunori Toyoda

This study examined outcomes of patients with acute ischemic stroke (AIS) with major cerebral artery occlusion after the approval of intravenous recombinant tissue-type plasminogen activator (IV rt-PA) but before approval of the MERCI retriever. We retrospectively enrolled 1170 consecutive patients with AIS and major cerebral artery occlusion (496 women; mean age, 73.9 ± 12.3 years) who were admitted within 24 hours after the onset of symptoms to 12 Japanese stroke centers between October 2005 and June 2009. Cardioembolism was a leading cause of AIS in this group (68.2%). The occlusion sites of the major cerebral arteries included the common carotid artery and internal carotid artery (ICA; 29.6%), middle cerebral artery (52.2%), and basilar artery (7.6%). Recanalization therapy (RT) was performed in 32.0% of patients (IV rt-PA, 20.0%; neuroendovascular therapy, 9.4%; combined, 2.5%). Symptomatic intracerebral hemorrhage within 36 hours with a ≥ 1-point increase in the National Institutes of Health Stroke Scale score occurred in 5.3% of the patients. At 3 months (or at hospital discharge), 29.3% of the patients had a favorable outcome (based on a modified Rankin scale score of 0-2), 23.8% were bedridden, and 15.6% died. After multivariate adjustment, RT was positively associated with a favorable outcome and negatively associated with death, whereas age, baseline National Institutes of Health Stroke Scale score, and ICA occlusion were negatively associated with a favorable outcome and positively associated with death. One-third of the patients with AIS and major cerebral artery occlusion were treated with RT, which was independently associated with favorable outcomes and death. However, 40% of the patients became bedridden or died during the post-alteplase, pre-MERCI era in Japan.

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Jyoji Nakagawara

Memorial Hospital of South Bend

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Takehiko Sasaki

Memorial Hospital of South Bend

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Norio Tanahashi

Saitama Medical University

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Rihei Takeda

Memorial Hospital of South Bend

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