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Dive into the research topics where Toshio Takahashi is active.

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Featured researches published by Toshio Takahashi.


Kidney International | 1999

Effect of vitamin E on lipid metabolism and atherosclerosis in ESRD patients

Masatoshi Mune; Susumu Yukawa; Masanori Kishino; Haruhisa Otani; Keigo Kimura; Osamu Nishikawa; Toshio Takahashi; Naoya Kodama; Yasushi Saika; Yoichi Yamada

BACKGROUND Oxidative stress is enhanced in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD). Bioincompatibility represents an important source of reactive oxygen species. HD patients exhibit altered anti-oxidative defences and anti-oxidative vitamins such as vitamin E and C are altered in uremia. Frequently, HD patients also suffer from atherosclerotic cardiac disease. We have previously reported that low density lipoprotein (LDL) of HD patients is rich in malondialdehyde (MDA), an end product of lipid peroxidation. MDA rich LDL is thought to be an atherogenic lipoprotein due to its enhancement of macrophage foam cell formation. METHODS We conducted a controlled study for two years comparing the effects of a vitamin E coated cellulose membrane dialyzer and an ordinary cellulose membrane dialyzer on lipid metabolism and the progress of atherosclerosis. LDL-MDA and oxidized LDL (ox-LDL) were measured in HD patients using these two types of dialyzers. Plasma vitamin E and lipid concentrations were also evaluated. The aortic calcification index (ACI) was evaluated by CT scan to assess the progress of atherosclerosis before and for every year after treatment. RESULTS Use of a vitamin E coated cellulose membrane dialyzer for six months, one year and two years resulted in a significant reduction in LDL-MDA and ox-LDL compared to the ordinary cellulose membrane dialyzer. Treatment with a vitamin E-coated dialyzer significantly reduced the percentage increase in ACI after 24 months compared to the control. There were no significant changes in plasma vitamin E and lipid concentrations between the two groups. CONCLUSIONS These results suggest that the oxidative stress could be one of the stimulating factors of abnormal lipid metabolism and atherosclerosis in ESRD patients.


Nihon Toseki Igakkai Zasshi | 1993

Clinical study of height change in patients on maintenance dialysis.

Toshihiro Kodama; Takuhiro Ikeda; Takako Norioka; Akihide Yukawa; Hiroko Saika; Toshio Takahashi; Yuuji Kita; Akefumi Maeda; Tomiya Abe

腎性骨異栄養症の補助診断およびその病態の評価をする目的で, 維持透析患者43例に対し2年間にわたり定期的身長測定を実施し, その身長変化と種々の臨床検査, 骨塩量, ビタミンD3投与量との比較検討を行った.身長は3か月毎に測定したが, 今回は1988年1月から1990年1月までの2年間における身長の変化を観察し, その身長変化と年齢, 透析歴, 血清Ca, P, ALP, C-PTH, AI, BMG, カルシトニン (CT) 等の血液検査との比較検討を行った.また, Digitallmage Processing Methodにて骨塩量 (ΣGS/D) を測定し, 身長変化と比較した. ビタミンD3投与量と身長変化との関係も合わせて検討した.身長縮小値と透析歴との間にr=0.307の正の相関傾向が, 血清Ca値との間にr=0.345の正の相関傾向が認められた. 身長縮小値と血清ALP値との間にr=0.670, p<0.01と正の相関が, 血青C-PTH値との間にr=0.701, p<0.01と正の相関が見られた. ΣGS/Dと身長縮小値, 血清ALP, C-PTH値との間に負の相関が認められた. ビタミンD3投与量と身長縮小値との間には相関は見られなかった.2年間に2cm以上の身長縮小をみた5症例中4症例に, 血清C-PTH値の異常高値が認められた.


Kanzo | 1980

Two cases of constitutional ICG excretory defect

Masahiro Kinoshita; Toshihiko Miyai; Takao Maeda; Keizo Kawano; Kenzi Taniguchi; Toshio Takahashi; Kazuo Mori; Susumu Yukawa; Hiroshi Nomoto; Seizi Ishitani

体質性ICG排泄異常症の二症例について報告する.症例1は偶然発見され,症例2は急性肝炎のため入院し発見された.二症例とも一般生化学的検査等には異常を示さず,ICG試験高度停滞とBSP試験との解離が認められた.症例1はnon specific reactive hepatitis,症例2は急性肝炎回復期の組織像であった.二症例の家族内に同様の解離現象を示すものが他に3名認められた.また症例1の家族内に3名のHBs抗原陽性と,3名のHBs抗体陽性のものが認められた.二症例とも血中ICG消失曲線に20分前後のステップ形成が認められた.Sephadex G-200を用いたカラムクロマトグラフィーによる血清蛋白とICGの結合パターンにコントロール群との差はみられなかった.超遠心分離法による血清リポ蛋白の分析では,各リポ蛋白分画へのICG結合率は変化していたけれども,各リポ蛋白分画の脂質量あたりのICG結合量には本二症例,コントロール群および肝硬変症の間に差はみられなかった,急性肝炎の検討では急性期にHDL2分画とHDL3分画の低下がみられICG結合率も低下していた.


Archive | 2000

Lamp unit using short-wave light emitting device

Kazuhiro Sakai; Toshio Takahashi; Takao Mukogawa; Tadanobu Iwasa


Kidney International | 1999

Effect of simvastatin on the lipid profile of hemodialysis patients

Osamu Nishikawa; Masatoshi Mune; Motoshige Miyano; Takahiro Nishide; Iwao Nishide; Akifumi Maeda; Keigo Kimura; Toshio Takahashi; Masanori Kishino; Yoshinori Tone; Haruhisa Otani; Akio Ogawa; Takao Maeda; Susumu Yukawa


Archive | 2002

Stator core for a magnetic bearing and the method of manufacturing it

Kazumitsu Hasegawa; Shinichi Ozaki; Toshio Takahashi; Gen Kuwata; Noriyasu Sugitani


Archive | 2006

Manufacturing method of perpendicular magnetic recording head

Masabumi Mochizuki; Akihiro Nanba; Toshio Takahashi; 正文 望月; 明博 難波; 俊雄 高橋


Archive | 2006

Hermetic turbo-compression refrigerating machine

Nobuyoshi Sakuma; Nobusada Takahara; Toshio Takahashi; 信義 佐久間; 伸定 高原; 俊雄 高橋


Kidney International | 1999

Erythropoietin supplement increases plasma lipoprotein lipase and hepatic triglyceride lipase levels in hemodialysis patients

Tetsuya Goto; Hiroko Saika; Toshio Takahashi; Akefumi Maeda; Masatoshi Mune; Susumu Yukawa


Archive | 2004

Method of manufacturing motor core, motor core and high frequency motor

Toshio Takahashi; 俊雄 高橋

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Susumu Yukawa

Wakayama Medical University

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Masatoshi Mune

Siebold University of Nagasaki

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Takao Maeda

Wakayama Medical University

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Haruhisa Otani

Wakayama Medical University

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Hiroshi Nomoto

Wakayama Medical University

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Masanori Kishino

Wakayama Medical University

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