Toshiro Morohoshi

Mycinamicin biosynthesis: intact incorporation of an intermediate by a chain-elongation process in Micromonospora griseorubida

The N-acetylcysteamine thioester of a hypothetical intermediate in the biosynthesis of mycinamicin was incorporated intact into mycinamicin aglycone in cooperation with dotriacolides in Micromonospora griseorubida.

Mycinamicin biosynthesis: isolation and structural elucidation of novel macrolactones and a seco acid produced by a mutant of Micromonospora griseorubida

Novel macrolide compounds and their biosynthetic intermediate, a seco acid, were isolated from the culture filtrate of a mutant strain of Micromonospora griseorubida, and their structures were determined on the basis of their spectroscopic data and X-ray diffraction analysis.