Toyoto Hijiya
Ajinomoto
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Publication
Featured researches published by Toyoto Hijiya.
Nucleosides, Nucleotides & Nucleic Acids | 1999
Toyoto Hijiya; Keizo Yamashita; Mitsuhiko Kojima; Yumiko Uchida; Satoshi Katayama; Takayoshi Torii; Hiroshi Shiragami; Kunisuke Izawa
An economical synthesis of famciclovir from N-2-acetyl-7-benzylguanine by a novel regioselective alkylation with the diester cyclopropane compound was developed.
Nucleosides, Nucleotides & Nucleic Acids | 2006
Takayoshi Torii; Keizo Yamashita; Mitsuhiko Kojima; Yumiko Suzuki; Toyoto Hijiya; Kunisuke Izawa
We have established practical synthetic methods for penciclovir (PCV, 1) and famciclovir (FCV, 2) from N2-acetyl-7-benzylguanine (NAc7BnG, 3) and 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (4)—the latter being a more easily prepared cyclic precursor of the diacetate side chain (5) used in the conventional process. The coupling of 4 with 3 proceeded regioselectively at the N9 position of guanine in good yield. The coupling product was then successfully transformed into the known antiviral agents in a short number of steps.
Archive | 1983
Kiyoshi Yoneda; Hiroshi Takeuchi; Tetsuo Yamatani; Toyoto Hijiya; Hideo Takeda; Koji Shibuya; Kiichiro Tanaka
Archive | 1985
Kunio Hisamitsu; Tadashi Takemoto; Toyoto Hijiya; Satoji Takahashi
Archive | 1996
Tadashi Takemoto; Toyoto Hijiya; Teruo Yonekawa
Bulletin of the Chemical Society of Japan | 1990
Hisao Iwagami; Masakazu Nakazawa; Masanobu Yatagai; Toyoto Hijiya; Yutaka Honda; Hirokazu Naora; Takashi Ohnuki; Toshihide Yukawa
Archive | 1985
Tadashi Takemoto; Toyoto Hijiya; Toshihide Yukawa
Archive | 1984
Tadashi Takemoto; Toyoto Hijiya; Tetsuo Yamatani
Tetrahedron | 2006
Takayoshi Torii; Hiroshi Shiragami; Keizo Yamashita; Yumiko Suzuki; Toyoto Hijiya; Tatsuki Kashiwagi; Kunisuke Izawa
Archive | 1996
Toyoto Hijiya; Toru Ikeda; Kenichi Mori; Toshihide Yukawa; Tadashi Takemoto; Hajime Kamada
