Tracie Barber

Computational fluid dynamics for the assessment of upper airway response to oral appliance treatment in obstructive sleep apnea

Mandibular advancement splints (MAS), which protrude the lower jaw during sleep, are recognized as an effective treatment for obstructive sleep apnea (OSA) through their action of enlarging the airway space and preventing upper airway collapse. However a clinical challenge remains in preselecting patients who will respond to this form of therapy. We aimed to use computational fluid dynamics (CFD) in conjunction with patient upper airway scans to understand the upper airway response to treatment. Seven OSA patients were selected based on their varied treatment response (assessed by the apnea-hypopnoea index (AHI) on overnight polysomnography). Anatomically-accurate upper airway computational models were reconstructed from magnetic resonance images with and without MAS. CFD simulations of airflow were performed at the maximum flow rate during inspiration. A physical airway model of one patient was fabricated and the CFD method was validated against the pressure profile on the physical model. The CFD analysis clearly demonstrated effects of MAS treatment on the patients UA airflow patterns. The CFD results indicated the lowest pressure often occurs close to the soft palate and the base of the tongue. Percentage change in the square root of airway pressure gradient with MAS (Δsqrt(ΔP(Max))%) was found to have the strongest relationship with treatment response (ΔAHI%) in correlation analysis (r=0.976, p=0.000167). Changes in upper airway geometry alone did not significantly correlate with treatment response. We provide further support of CFD as a potential tool for prediction of treatment outcome with MAS in OSA patients without requiring patient specific flow rates.

Aerodynamic ground effect : a case study of the integration of CFD and experiments

Ground effect aerodynamics, although a subject of much interest to automotive, aircraft and naval architecture designers, is still an area of some uncertainty due to the problematic nature of experimental (and sometimes numerical) simulation. An integrated study, making use of both experimental (Particle Imaging Velocimetry) and numerical techniques (Computational Fluid Dynamics finite volume solver), is used to demonstrate the effect and importance of the common assumptions and simulation issues. For certain important ground effect situations, it becomes clear that a numerical simulation is the only feasible option; however, a careful and systematic study of similar experiments is vital to gain the confidence required in the numerical solution. Only when this confidence has been gained, can the numerical simulation confidently be used for prediction of the experimentally unfeasible, but important, situation. Three ambiguous areas of ground effect aerodynamics are identified, and a combination of numerical and experimental results presented.

CFD Analysis of the Acoustic and Mean Flow Performance of Simple Expansion Chamber Mufflers

The acoustic and mean flow performance of different configurations of simple expansion chamber mufflers has been considered. The different configurations include extended inlet/outlet pipes and baffles inside the expansion section of the muffler. Both the acoustic and mean flow performance has been evaluated for each muffler. The acoustic CFD model of the muffler uses an axisymmetric grid with no mean flow and a single period sinusoid of suitable amplitude and duration imposed at the inlet boundary. The time history of the acoustic pressure and particle velocity are recorded at two points, one in the inlet pipe and the other in the outlet pipe. These time histories are Fourier transformed and the transmission loss of the muffler is calculated. The mean flow model of the muffler uses the same geometry, but has a finer mesh and has a suitable inlet velocity applied at the inlet boundary and the pressure drop across the muffler is found. The acoustic performance is compared with published experimental results.Copyright

Influence of wing span on the aerodynamics of wings in ground effect

A computational fluid dynamics study of the influence of wing span has been conducted for an inverted wing with endplates in ground effect. Aerodynamic coefficients were determined for different spans at different ground clearances, highlighting a trend for shorter spans to delay the onset of both separation and resulting loss of negative lift. The vortices at the wing endplates were not observed to change significantly in terms of strength and size; thus, at shorter spans, their influence over a larger percentage of the wing helped the flow stay attached and reduced the severity of the adverse pressure gradient which invokes separation at greater spans. Consequently, it was shown that, compared to a large-span wing, a wing with a shorter span may have a lower lift coefficient but can operate closer to the ground before performance is adversely affected.

The flow field near a venous needle in hemodialysis: A computational study

The vascular access used in hemodialysis can suffer from numerous complications, which may lead to failure of the access, patient morbidity, and significant costs. The flow field in the region of the venous needle may be a source of damaging hemodynamics and hence adverse effects on the fistula. In this study, the venous needle flow has been considered, using three‐dimensional computational methods. Four scenarios where the venous needle flow could potentially influence dialysis treatment outcome were identified and examined: Variation of the needle placement angle (10°, 20°, 30°), variation of the blood flow rate settings (200, 300, 400 mL/min), variation of the needle depth (top, middle, bottom), and the inclusion of a back eye in the needle design. The presence of the needle has significant effect on the flow field, with different scenarios having varying influence. In general, wall shear stresses were elevated above normal physiological values, and increased presence of areas of low velocity and recirculation—indicating increased likelihood of intimal hyperplasia development—were found. Computational results showed that the presence of the venous needle in a hemodialysis fistula leads to abnormal and potentially damaging flow conditions and that optimization of needle parameters could aid in the reduction of vascular access complications. Results indicate shallow needle angles and lower blood flow rates may minimize vessel damage.

Manufacturing and wetting low-cost microfluidic cell separation devices

Deterministic lateral displacement (DLD) is a microfluidic size-based particle separation or filter technology with applications in cell separation and enrichment. Currently, there are no cost-effective manufacturing methods for this promising microfluidic technology. In this fabrication paper, however, we develop a simple, yet robust protocol for thermoplastic DLD devices using regulatory-approved materials and biocompatible methods. The final standalone device allowed for volumetric flow rates of 660 μl min(-1) while reducing the manufacturing time to <1 h. Optical profilometry and image analysis were employed to assess manufacturing accuracy and precision; the average replicated post height was 0.48% less than the average post height on the master mold and the average replicated array pitch was 1.1% less than the original design with replicated posts heights of 62.1 ± 5.1 μm (mean ± 6 standard deviations) and replicated array pitches of 35.6 ± 0.31 μm.

Ground effect phenomena about lift and downforce generating cambered aerofoils

Purpose – Investigations into ground effect phenomena about aerofoils are typically conducted on either an upright (lift‐producing) or inverted (downforce‐producing) configuration, in isolation. This limited approach does not promote a holistic understanding of how ground effect influences aerofoils. This paper aims to address this issue.Design/methodology/approach – A two‐dimensional computational fluid dynamics investigation was conducted on the highly cambered Tyrrell aerofoil, in both its upright and inverted configurations, in order to better understand ground effect phenomena by observing how it influences each configuration differently. The trends in force and flow field behaviour were observed at various ground clearances through observation of the normal and drag forces and pressure coefficient plots. The aerofoil was held stationary and at a constant angle of attack of 6 degrees, with a moving ground plane to simulate the correct relative motion.Findings – The different ground effect mechanisms ...

Analysis of Drug Distribution from a Simulated Drug-Eluting Stent Strut Using an In Vitro Framework

The mechanisms of delivery of anti-proliferative drug from a drug-eluting stent are defined by transport forces in the coating, the lumen, and the arterial wall. Dynamic asymmetries in the localized flow about stent struts have previously been shown to contribute to significant heterogeneity in the spatial distribution of drug in in silico three-compartmental models of stent based drug delivery. A novel bench-top experiment has been created to confirm this phenomena. The experiment simulates drug release from a single stent strut, and then allows visualization of drug uptake into both lumen and tissue domains using optical techniques. Results confirm the existence of inhomogeneous and asymmetric arterial drug distributions, with this distribution shown to be sensitive to the flow field surrounding the strut.The mechanisms of delivery of anti-proliferative drug from a drug-eluting stent are defined by transport forces in the coating, the lumen, and the arterial wall. Dynamic asymmetries in the localized flow about stent struts have previously been shown to contribute to significant heterogeneity in the spatial distribution of drug in in silico three-compartmental models of stent based drug delivery. A novel bench-top experiment has been created to confirm this phenomena. The experiment simulates drug release from a single stent strut, and then allows visualization of drug uptake into both lumen and tissue domains using optical techniques. Results confirm the existence of inhomogeneous and asymmetric arterial drug distributions, with this distribution shown to be sensitive to the flow field surrounding the strut.

LES and Multi-Step Chemical Reaction in Compartment Fires

Numerical studies on two large-scale compartment buoyant fires were performed utilizing a fully coupled Large Eddy Simulation (LES) and strained laminar flamelet combustion model, extended from single-step to multistep chemical reaction. Two Subgrid-Scaled (SGS) turbulent models, Smagorinsky and WALE, were examined for center and corner fires. Compared with the experimental and existing numerical data, the WALE model with a multistep chemical reaction gave the best prediction for the upper hot layer and doorway gas temperatures. Specie concentrations including oxygen, carbon dioxide, and carbon monoxide were also found to compare well against the experimental measurements when the WALE model with a multistep chemical reaction was adopted.

Determining possible thrombus sites in an extracorporeal device, using computational fluid dynamics-derived relative residence time

The prediction of conditions that may result in thrombus formation is a useful application of computational fluid dynamics. A number of techniques exist, based on the consideration of wall shear stress and regions of low blood flow; however, no clear guideline exists for the best practice of their use. In this paper, the sensitivity of each parameter and the specific mechanical forces are explained, before the optimal indicator of thrombosis risk is outlined. An extracorporeal access device cavity provides a suitable geometry to test the methodology. The recommended method for thrombus prediction considers areas with a calculated residence time (RT) and shear strain rate (SSR) thresholds, here set to RT>1 and SSR < 10 s− 1. Evidence of thrombosis was found for physiological waveforms with an absence of reverse flow, which is expected to ‘wash out’ the cavity. The predicted thrombosis sites compare well with evidence collected from explanted devices.