Tram N. Huynh
Schering-Plough
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Publication
Featured researches published by Tram N. Huynh.
Tetrahedron | 2000
Stuart B. Rosenblum; Tram N. Huynh; Adriano Afonso; Harry R. Davis
A series of 3-(3′-arylpropenyl)-2-azetidinones 8a–8k and 3-(3′-arylpropynyl)-2-azetidinones 16m–16p were prepared by the palladium-catalyzed arylation of 3-(3′-propenyl)-2-azetidinone 7, or by arylation of 4-pentenoic acid, or via ethyl 4-pentynoate followed by 2-azetidinone ring construction. The unsaturated 2-azetidinones were transformed to their saturated analogs 9a–9p by catalytic hydrogenation. Azetidinones 8a–8k, 9a–9p, and 16m–16p were evaluated for their biological activity as cholesterol absorption inhibitors in hamsters.
Journal of Medicinal Chemistry | 2010
Bingwei V. Yang; David S. Weinstein; Lidia M. Doweyko; Hua Gong; Wayne Vaccaro; Tram N. Huynh; Hai-Yun Xiao; Arthur M. Doweyko; Lorraine I. McKay; Deborah A. Holloway; John E. Somerville; Sium Habte; Mark D. Cunningham; Michele McMahon; Robert Townsend; David J. Shuster; John H. Dodd; Steven G. Nadler; Joel C. Barrish
A series of 2,2-dimethyl-3,3-diphenyl-propanamides as novel glucocorticoid receptor modulators is reported. SAR exploration led to the identification of 4-hydroxyphenyl propanamide derivatives displaying good agonist activity in GR-mediated transrepression assays and reduced agonist activity in GR-mediated transactivation assays. Compounds 17 and 30 showed anti-inflammatory activity comparable to prednisolone in the rat carrageenan-induced paw edema model, with markedly decreased side effects with regard to increases in blood glucose and expression of hepatic tyrosine aminotransferase. A hypothetical binding mode accounting for the induction of the functional activity by a 4-hydroxyl group is proposed.
Journal of Medicinal Chemistry | 2012
Heather Finlay; John Lloyd; Wayne Vaccaro; Alexander Kover; Lin Yan; Gauri Bhave; Joseph Prol; Tram N. Huynh; Rao S. Bhandaru; Yolanda Caringal; John D. Dimarco; Jinping Gan; Tim Harper; Christine Huang; Mary Lee Conder; Huabin Sun; Paul Levesque; Michael A. Blanar; Karnail S. Atwal; Ruth R. Wexler
Previously disclosed dihydropyrazolopyrimidines are potent and selective blockers of I(Kur) current. A potential liability with this chemotype is the formation of a reactive metabolite which demonstrated covalent binding to protein in vitro. When substituted at the 2 or 3 position, this template yielded potent I(Kur) inhibitors, with selectivity over hERG which did not form reactive metabolites. Subsequent optimization for potency and PK properties lead to the discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone (13j), with an acceptable PK profile in preclinical species and potent efficacy in the preclinical rabbit atrial effective refractory period (AERP) model.
Journal of Medicinal Chemistry | 1998
Stuart B. Rosenblum; Tram N. Huynh; Adriano Afonso; Harry R. Davis; Nathan Yumibe; John W. Clader; Duane A. Burnett
Archive | 2013
Ashok V. Purandare; Brian E. Fink; Walter Lewis Johnson; Amy C. Hart; Liqi He; Tram N. Huynh; Jennifer Inghrim; Harold Mastalerz; Xiaopeng Sang; Christine M. Tarby; Honghe Wan; Wayne Vaccaro; Guifen Zhang; Yufen Zhao; Kurt Zimmermann; Yong Zhang; Libing Chen; Bin Chen; John S. Tokarski; Ashvinikumar V. Gavai
Cancer Research | 2018
Ashvinikumar V. Gavai; Derek J. Norris; David R. Tortolani; Daniel O'malley; Yufen Zhao; Claude A. Quesnelle; Patrice Gill; Wayne Vaccaro; Tram N. Huynh; Vijay T. Ahuja; Dharmpal S. Dodd; Christopher P. Mussari; Lalgudi S. Harikrishnan; Muthoni G. Kamau; John S. Tokarski; Steven Sheriff; Richard Rampulla; Dauh-Rurng Wu; Jianqing Li; Huiping Zhang; Peng Li; Dawn Sun; Henry Yip; Yingru Zhang; Arvind Mathur; Haiying Zhang; Christine Huang; Zheng Yang; Asoka Ranasinghe; Celia D'Arienzo
Archive | 2017
Amy C. Hart; Ashok V. Purandare; Ashvinikumar V. Gavai; Bin Chen; Brian E. Fink; Christine M. Tarby; Guifen Zhang; Harold Mastalerz; Honghe Wan; Jennifer Inghrim; John S. Tokarski; Kurt Zimmermann; Libing Chen; Liqi He; Tram N. Huynh; Walter Lewis Johnson; Wayne Vaccaro; Xiaopeng Sang; Yong Zhang; Yufen Zhao
Archive | 2017
Sanjeev Gangwar; Robert M. Borzilleri; Tram N. Huynh; Naidu S. Chowdari; Ivar M Mdonald; Yong Zhang
Archive | 2016
Gretchen M. Schroeder; Tram N. Huynh; Heidi L. Perez
Archive | 2007
Bingwei Vera Yang; Lidia M. Doweyko; Wayne Vaccaro; Tram N. Huynh; David R. Tortolani; T. G. Murali Dhar