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Troy Anthony Appleton

Pfizer

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Publication

Featured researches published by Troy Anthony Appleton.

Bioorganic & Medicinal Chemistry Letters | 1995

A water soluble benzazepine cholecystokinin-B receptor antagonist

John A. Lowe; Susan E. Drozda; Stafford McLean; Dianne K. Bryce; Rosemary T. Crawford; Stevin H. Zorn; Jean Morrone; Troy Anthony Appleton; Franco Lombardo

Abstract A series of 5-substituted-3-ureidobenzazepin-2-ones bearing ioizable functionality was synthesized as potential cholecystokinin-B (CCK-B) receptor antagonists. SAR of this series of compounds demonstrated the optimal combination of a carboxylic acid and 5-cyclohexyl group, providing the high affinity (CCK-B IC 50 = 0.10 nM), water soluble CCK-B antagonist 2 .

Journal of the American Chemical Society | 2000

Preparation of Fluoroadamantane Acids and Amines: Impact of Bridgehead Fluorine Substitution on the Solution- and Solid-State Properties of Functionalized Adamantanes

V. John Jasys; Franco Lombardo; Troy Anthony Appleton; Jon Bordner; and Martine Ziliox; Robert A. Volkmann

Archive | 2000

4-carboxyamino-2-ethyl-1,2,3,4-tetrahydroquinoline crystal as cetp inhibitor

Douglas John Meldrum Allen; Troy Anthony Appleton; Lyle Robinson Brostrom; Derek L. Tickner

Archive | 2000

Polymorphs of a crystalline azo-bicyclo 2,2,2 OCT-3-yl amine dihydrochloride and their pharmaceutical compositions

Douglas John Meldrum Allen; Troy Anthony Appleton; Michael Jon Gumkowski; David Joseph Muehlbauer; Timothy Norris

Archive | 2000

Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2.2.2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-amine citrate as nk-1 receptor antagonists

Douglas John Meldrum Allen; Troy Anthony Appleton; Michael Jon Gumkowski; David Joseph Muehlbauer; Timothy Norris

Archive | 2004

FORME CRISTALLINE DE 4-CARBOXYAMINO-2-ETHYL-1,2,3,4-

Douglas John Meldrum Allen; Troy Anthony Appleton; Derek L. Tickner; Lyle Robinson Brostrom

Archive | 2004

Polymorphes d'un chlorhydrate d'azo-bicyclo-2,2,2-oct-3-ylamine cristallins et compositions pharmaceutiques les contenant.

Douglas John Meldrum Allen; Troy Anthony Appleton; Michael Jon Gumkowski; David Joseph Muehlbauer; Timothy Norris

Archive | 2002

FORME CRISTALLINE DE 4-CARBOXYAMINO-2-SUBSTITUE-1,2,3,4- TETRAHYDROQUINOLEINE, ET COMPOSITIONS LA CONTENANT

Troy Anthony Appleton; Lyle Robinson Brostrom; Derek L. Tickner; Douglas John Meldrum Allen

Archive | 2000

Polymorphs of crystalline azo-bicyclo 2,2,2,oct-3-yl amine dihydrochloride and their pharmaceutical compositions

David Joseph Muehlbauer; Timothy Norris; Douglas John Meldrum Allen; Troy Anthony Appleton; Michael Jon Gumkowski

Archive | 2000

Cristaux de 4-carboxyamino-2-ethyl-1,2,3,4-tetrahydroquinoleine utilises en tant qu'inhibiteurs de cetp

Douglas John Meldrum Allen; Troy Anthony Appleton; Lyle Robinson Brostrom; Derek L. Tickner

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Douglas John Meldrum Allen

Pfizer

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David Joseph Muehlbauer

Pfizer

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Derek L. Tickner

Pfizer

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Lyle Robinson Brostrom

Pfizer

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Michael Jon Gumkowski

Pfizer

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Timothy Norris

Pfizer

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Franco Lombardo

Pfizer

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Ward Marvin Smith

Pfizer

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Dianne K. Bryce

Pfizer

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Jean Morrone

Pfizer

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