Truc Chi Vu

Synthesis of substituted 2,3-dihydrobenzofuran in a process involving a facile acyl migration

Abstract Reduction of 2,6-diacetoxy-2′-bromoacetophenone ( 10 ) with NaBH 4 led to 3,4-diacetoxydihydrobenzofuran ( 12 ) in a process involving acyl migration followed by cyclization. Subsequent hydrogenolysis gave 4-acetoxydihydrobenzofuran which, upon saponification, afforded 4-hydroxydihydrobenzofuran ( 8 ) in good yield. This approach is shown to be a general method for preparation of substituted dihydrobenzofurans.

Synthesis and anti-MRSA Activity of Novel Cephalosporin Derivatives

Abstract Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to exhibit potent anti-MRSA activity in vitro and in vivo. The optimum C-7 sidechains utilized were 2,5-dichlorophenylthioacetamido and 2,6-dichloropyrid-4-ylthioacetamido. The C-3 thiopyridinium rings were substituted at nitrogen with amino acid and pyruvic acid groups that were designed to confer aqueous solubility as required for IV formulation. This paper describes the characteristics of these novel cephalosporins and highlights synthetic methods developed to allow their practical, large-scale syntheses.