Tsukasa Kuraishi

Directed lithiation of 1-(tert-butoxycarbonyl)indolines. A convenient route to 7-substituted indolines

1-(tert-Butoxycarbonyl)indolines were regioselectivity lithiated at 7-position with s-BuLi-TMEDA in ether or THF at −78°C. The lithiated species were reacted with a range of electrophiles to give 7-substituted indoline derivatives

Synthesis of (±)-sesbanine via directed metalation of tertiary nicotinamides

Abstract Racemic sesbanine was synthesized by using regioselective ortho lithiation of N,N-dialkylnicotinamides and subsequent condensation with 3-cyclopentenone as key reactions.

A novel naphthoquinone synthesis via tandem directed lithiations

Synthese de naphtoquinones-1,4 a partir de N,N-diethylbenzamides via des phenylthio-2 naphtoquinones-1,4