Tsunehiko Asako

Selective Phosphorylation of the 5′′-Hydroxy Group of Ribostamycin by a New Enzyme from Pseudomonas aeruginosa

It was found that the 5′′-hydroxy group of ribostamycin was preferentially phosphorylated by a cell-free extract from Pseudomonas aeruginosa GN 573, a clinical isolate.

Synthesis of the steroid (±)-17α-ethynyl-17β-hydroxy-13β-allylgon-4-en-3-one

The title compound was synthesized using various methods of protecting the C-13 allyl group from reducing agents.

Studies on the total synthesis of steroids: the structure of 9,14-epoxy-steroids

The 9S configuration is assigned to the more stable 9,14α-epoxy-3-methoxy-8,14-seco-oestra-1,3,5(10)-trien-17-one.

Total synthesis of oestrone via oestriol dimethyl ether

Cyclization of seco-oestrapentaene (IV) gave an oestriol derivative (V), which was further transformed to oestrone.