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Featured researches published by Tsung Hsueh Lu.


Social Science & Medicine | 2009

Was the economic crisis 1997-1998 responsible for rising suicide rates in East/Southeast Asia? A time-trend analysis for Japan, Hong Kong, South Korea, Taiwan, Singapore and Thailand

Shu-Sen Chang; David Gunnell; Jonathan A C Sterne; Tsung Hsueh Lu; Andrew Cheng

In 1997-1998 a widespread economic crisis hit the economies of many East/Southeast Asian countries; its impact on suicide rates across the region has not been systematically documented. We investigated the impact of the Asian economic crisis (1997-1998) on suicide in Japan, Hong Kong, South Korea, Taiwan, Singapore and Thailand. Suicide and population data for the period 1985-2006 were extracted from the World Health Organisations mortality database and Taiwanese mortality statistics. Sex-specific age-standardised suicide rates for people aged 15years or above were analysed using joinpoint regression. Trends in divorce, marriage, unemployment, gross domestic product (GDP) per capita and alcohol consumption were compared with trends in suicide rates graphically and using time-series analysis. Suicide mortality decreased in the late 1980s and early 1990s but subsequently increased markedly in all countries except Singapore, which had steadily declining suicide rates throughout the study period. Compared to 1997, male rates in 1998 rose by 39% in Japan, 44% in Hong Kong and 45% in Korea; rises in female rates were less marked. Male rates also rose in Thailand, but accurate data were incomplete. The economic crisis was associated with 10,400 more suicides in 1998 compared to 1997 in Japan, Hong Kong and Korea. Similar increases in suicide rates were not seen in Taiwan and Singapore, the two countries where the economic crisis had a smaller impact on GDP and unemployment. Time-series analyses indicated that some of the crisiss impact on male suicides was attributable to increases in unemployment. These findings suggest an association of the Asian economic crisis with a sharp increase in suicide mortality in some, but not all, East/Southeast Asian countries, and that these increases were most closely associated with rises in unemployment.


BMC Public Health | 2008

Suicide mortality trends by sex, age and method in Taiwan, 1971–2005

Jin-Jia Lin; Tsung Hsueh Lu

BackgroundMethod-specific suicide trends varied across countries, and studies of the trends in different countries can contribute to the understanding of the epidemiology of suicide. The purpose of this study was to examine the changes in suicide trends by sex, age and method in the years 1971 to 2005 in Taiwan.MethodsMortality data files of suicide and undetermined deaths for the years 1971–2005 were obtained for analyses. Age-, sex- and method-specific suicide rates were calculated by four age groups (15–24, 25–44, 45–64 and 65 and above) and five suicide methods (solids/liquids poisoning, other gases poisoning, hanging, jumping, and others).ResultsBoth sexes experienced downward trends from 1971 to 1993, and then an upward trend since 1993. People aged 65 years and above had the highest suicide rates throughout the study periods. However, males aged 25–64 years experienced the steepest increasing trends. As to suicide methods, an annual increase, since 1991, of people jumping from heights to commit suicide, and a marked increase, since 1998, of people completing suicide by poisoning with other gases (mainly charcoal-burning) were observed.ConclusionSuicide by means of charcoal-burning and jumping from heights has become a serious public health problem in Taiwan. Preventive measures to curb these increasing trends are urgently needed.


Health & Place | 2011

Geography of suicide in Taiwan: Spatial patterning and socioeconomic correlates

Shu-Sen Chang; Jonathan A C Sterne; Benedict W. Wheeler; Tsung Hsueh Lu; Jin-Jia Lin; David Gunnell

In industrialised Western nations suicide rates tend to be high in inner city areas and socially fragmented neighbourhoods. Few studies have investigated spatial variations in suicide in non-Western settings. We estimated smoothed standardised mortality ratios (1999-2007) for suicide for each of the 358 Taiwanese districts (median population aged 15+: 27,000) and investigated their associations with area characteristics using Bayesian hierarchical models. The geographic distribution of suicide was similar in men and women; young people showed the greatest spatial variation in rates. Rates were highest in East Taiwan, a mostly mountainous rural area. There was no evidence of above average rates in large cities. Spatial patterns of method-specific suicide rates varied markedly, with solids/liquids poisonings showing the greatest geographic variation and hangings the least. Factors most strongly associated with area suicide rates were median household income, population density and lone-parent households. Spatial patterning of suicide in Taiwan differed from that observed in Western nations. Suicide prevention strategies should take into account unique local patterns.


Social Psychiatry and Psychiatric Epidemiology | 2010

‘Hidden’ suicides amongst deaths certified as undetermined intent, accident by pesticide poisoning and accident by suffocation in Taiwan

Shu-Sen Chang; Jonathan A C Sterne; Tsung Hsueh Lu; David Gunnell

ObjectiveTo identify cause-of-death categories in which suicides might be misclassified in Taiwan.MethodsWe plotted secular trends (1971–2007) in sex- and method-specific rates of deaths classified as suicide, undetermined intent and accident for the Taiwanese population aged 15+ and compared the sex, age and marital status profiles of deaths in these three categories by method of death.ResultsThe demographic profiles of registered suicides generally resembled those for deaths of undetermined intent and accidents by pesticide poisoning/suffocation but differed from those for accidents from non-pesticide poisoning/drowning/falling/poisoning by non-domestic gas. For the period 1990–2007, suicide rates based on suicides alone (14.8 per 100,000) would increase by 23, 7 and 1%, respectively, when including deaths of undetermined intent, accidental pesticide poisonings and accidental suffocations.ConclusionsSuicide rates may be underestimated by more than 30% in Taiwan because some suicides are ‘hidden’ amongst deaths certified as due to other causes.


Annals of the Rheumatic Diseases | 2012

Incidence of cancer in a nationwide population cohort of 7852 patients with primary Sjogren's syndrome in Taiwan

Meng Yu Weng; Yu Tung Huang; Ming Fei Liu; Tsung Hsueh Lu

Objectives Patients with primary Sjögrens syndrome (pSS) are at a higher risk of developing non-Hodgkins lymphoma (NHL). However, little is known with regard to the risk of developing cancers other than NHL. The authors aimed in this study to compare the incidence of cancer in various sites among patients with pSS with the general population of Taiwan. Methods The authors used National Health Insurance claims data to establish a nationwide population cohort of 7852 patients with pSS from 2000 to 2008 who did not have cancer prior to diagnosis of pSS. Incidence and standardised incidence ratios (SIRs) for cancer in various sites were calculated. Results Among patients with pSS, 277 (2.9%) developed cancer. The SIR for cancer was 1.04 (95% CI 0.91 to 1.18) among patients of all ages with pSS and was 2.19 (95% CI 1.43 to 3.21) for patients aged 25–44 years. Female patients with pSS had a higher risk of NHL (SIR 7.1, 95% CI 4.3 to 10.3), multiple myeloma (SIR 6.1, 95% CI 2.0 to 14.2) and thyroid gland cancer (SIR 2.6, 95% CI 1.4 to 4.3) and a lower risk of colon cancer (SIR 0.22, 95% CI 0.05 to 0.65). In contrast, male patients with pSS were not at a higher risk of developing cancer in particular sites. Conclusion Patients with pSS, overall, did not have higher risk of cancer, and only patients aged 25–44 years were at an increased risk of cancer compared with their counterparts in the general population. Cancer screening for patients with pSS, especially female patients, should focus on NHL and multiple myeloma and thyroid gland cancer.


BMC Public Health | 2010

The leading methods of suicide in Taiwan, 2002-2008

Jin Jia Lin; Shu-Sen Chang; Tsung Hsueh Lu

BackgroundDiverse socioeconomic and cultural developments between geographic regions and cities/counties have resulted in different physical availability and socio-cultural acceptability of certain methods of suicide. This study examined the changes in distribution of the leading methods of suicide across cities/counties in Taiwan between 2002-04 and 2006-08.MethodsMortality data for all deaths classified as suicide or as of undetermined intent from 2002 through 2008 were extracted for analysis. The number of deaths and proportion of completed suicides by four main methods were calculated in order to identify the leading lethal methods in each city/county.ResultsHanging was the leading method of suicide in 18 out of 22 cities/counties in 2002-04 but decreased to 10 out of 22 in 2006-08. On the other hand, charcoal burning was not the leading method in any city/county in 2002-04 but increased to 10 out of 22 in 2006-08. The younger the age of the deceased, the more likely the leading method of suicide changed from 2002-04 to 2006-08. Charcoal burning was the most often used method in most cities/counties among those aged 15-44; however, hanging was most frequent for those aged 45 or above. Pesticides were the leading method for the elderly in five counties with a high percentage of agricultural population in 2006-08.ConclusionThe leading method of suicide varied by age group and changed from 2002-04 to 2006-08 in Taiwan. This was due primarily to changes in socio-cultural acceptability of the use of charcoal burning as a method for suicide by younger age groups.


American Journal of Epidemiology | 2010

Trends in Frequency of Reporting Improper Diabetes-related Cause-of-Death Statements on Death Certificates, 1985–2005: An Algorithm to Identify Incorrect Causal Sequences

Tsung Hsueh Lu; Robert N. Anderson; Ichiro Kawachi

This study aimed to examine the changes in frequency of reporting improper diabetes-related cause-of-death statements on death certificates based on Multiple-Cause Mortality Files of the United States from 1985 to 2005. An algorithm was developed to identify the causes of death with incorrect causal sequences by using decision tables developed by the National Center for Health Statistics. In 1985, 2 or more diagnoses per line were reported on 35% of death certificates with mention of diabetes in Part I of the death certificate. This percentage decreased to 19% in 2005. In contrast, the prevalence of reporting incorrect causal sequences on death certificates on which diabetes was reported in Part I increased from 22% in 1985 to 35% in 2005. The authors suggest that the most plausible explanation of increasing reporting of incorrect causal sequences was the drastic increase of reporting multiple conditions (especially cardiovascular diseases and cancers) among deaths with mention of diabetes, which made the determination of underlying cause of death much more difficult.


Clinical Toxicology | 2012

Factors associated with the decline in suicide by pesticide poisoning in Taiwan: A time trend analysis, 1987–2010

Shu-Sen Chang; Tsung Hsueh Lu; Michael Eddleston; Flemming Konradsen; Jonathan A C Sterne; Jin Jia Lin; David Gunnell

Objective. Pesticide self-poisoning accounts for one-third of suicides worldwide, but few studies have investigated the national epidemiology of pesticide suicide in countries where it is a commonly used method. We investigated trends in pesticide suicide, and factors associated with such trends, in Taiwan, a rapidly developing East Asian country. Methods. We conducted an ecological study using graphical approaches and Spearmans correlation coefficients to examine trends in pesticide suicide (1987–2010) in Taiwan in relation to pesticide sales, bans on selected pesticides, the proportion of the workforce involved in agriculture and unemployment. We compared pesticide products banned by the Taiwanese government with products that remained on the market and pesticides that accounted for the most poisoning deaths in Taiwan. Results. Age-standardised rates of pesticide suicide showed a 67% reduction from 7.7 per 100,000 (42% of all suicides) in 1987 to 2.5 per 100,000 (12% of all suicides) in 2010, in contrast to a 69% increase in suicide rates by other methods. Pesticide poisoning was the most commonly used method of suicide in 1987 but had become the third most common method by 2010. The reduction was paralleled by a 66% fall in the workforce involved in agriculture but there was no strong evidence for its association with trends in pesticide sales, bans on selected pesticide products or unemployment. The bans mostly post-dated the decline in pesticide suicides; furthermore, they did not include products (e.g. paraquat) that accounted for most deaths and were mainly restricted to selected high-strength formulated products whilst their equivalent low-strength products were not banned. Conclusions. Access to pesticides, indicated by the size of agricultural workforce, appears to influence trends in pesticide suicide in Taiwan. Targeted bans on pesticides should focus on those products that account for most deaths.


Child Care Health and Development | 2010

Adverse birth outcomes among pregnancies of teen mothers: age-specific analysis of national data in Taiwan

C.-W. Chen; C.-Y. Tsai; Fung-Chang Sung; Y.-Y. Lee; Tsung Hsueh Lu; Chung Yi Li; M.-C. Ko

BACKGROUND This study was conducted to evaluate the risks of adverse birth outcomes including low birthweight, preterm and small-for-gestational age among teen mothers. METHODS Data were collected from the Taiwan Birth Registry between 1985 and 1997. Among a total of 1,185,597 live births born to mothers aged 24 years or less, 151,259 (12.8%) were born to teen mothers aged 19 years or less. Crude odds ratios (ORs), adjusted ORs (AORs), their 95% confidence intervals and test for linear trend of maternal age-specific AOR were estimated using logistic regression analysis. RESULTS After controlling for certain birth characteristics and socio-economic factors, the age-specific analysis showed significantly gradient variations in increased risks of adverse birth outcomes among births of teen mothers, where the elevated risk was lessened in older teen mothers. Teen mothers aged 16 years or less were observed to experience particularly high AORs for all adverse birth outcomes of interest. CONCLUSIONS Not all teen mothers experienced the same magnitude of increased risk of adverse birth outcomes in Taiwan. Considering all teen mothers as the same group may have overlooked the particularly high risks of adverse birth outcomes among very young teen mothers (16 years or less), who are especially vulnerable to such elevated risks.


Injury Prevention | 2015

Unintentional drowning mortality, by age and body of water: an analysis of 60 countries.

Ching Yih Lin; Yi Fong Wang; Tsung Hsueh Lu; Ichiro Kawach

Background To examine unintentional drowning mortality by age and body of water across 60 countries, to provide a starting point for further in-depth investigations within individual countries. Methods The latest available three years of mortality data for each country were extracted from WHO Health Statistics and Information Services (updated at 13 November 2013). We calculated mortality rate of unintentional drowning by age group for each country. For countries using International Classification of Disease 10 (ICD-10) detailed 3 or 4 Character List, we further examined the body of water involved. Results A huge variation in age-standardised mortality rate (deaths per 100 000 population) was noted, from 0.12 in Turkey to 9.19 in Guyana. Of the ten countries with the highest age-standardised mortality rate, six (Belarus, Lithuania, Latvia, Russia, Ukraine and Moldova) were in Eastern Europe and two (Kazakhstan and Kyrgyzstan) were in Central Asia. Some countries (Japan, Finland and Greece) had a relatively low rank in mortality rate among children aged 0–4 years, but had a high rank in mortality rate among older adults. On the contrary, South Africa and Colombia had a relatively high rank among children aged 0–4 years, but had a relatively low rank in mortality rate among older adults. With regard to body of water involved, the proportion involving a bathtub was extremely high in Japan (65%) followed by Canada (11%) and the USA (11%). Of the 13 634 drowning deaths involving bathtubs in Japan between 2009 and 2011, 12 038 (88%) were older adults aged 65 years or above. The percentage involving a swimming pool was high in the USA (18%), Australia (13%), and New Zealand (7%). The proportion involving natural water was high in Finland (93%), Panama (87%), and Lithuania (85%). Conclusions After considering the completeness of reporting and quality of classifying drowning deaths across countries, we conclude that drowning is a high-priority public health problem in Eastern Europe, Central Asia, Japan (older adults involving bathtubs), and the USA (involving swimming pools).

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Fu Wen Liang

National Cheng Kung University

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Chung Yi Li

National Cheng Kung University

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Tung-Liang Chiang

National Taiwan University

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Shu-Sen Chang

National Taiwan University

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Tain Junn Cheng

Chia Nan University of Pharmacy and Science

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Jo Chi Lee

National Cheng Kung University

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Wei Hsian Yin

National Yang-Ming University

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Ya Li Huang

Taipei Medical University

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