Turhan Okten

Anti-CD10 (56C6) expression in soft tissue sarcomas.

CD10 is known to be expressed in certain types of leukemia, in lymphomas and also in various types of carcinoma. However, data regarding CD10 expression in soft tissue sarcomas is scarce. Two hundred and two retrospective soft tissue sarcoma specimens were evaluated for CD10 expression immunohistochemically. The clinical records of these patients were reviewed, and clinical data was obtained for all patients. Our results showed that 90 of the 202 cases were found to express CD10. 72% of malignant fibrous histiocytomas, 45% of fibrosarcomas, 34% of rhabdomyosarcomas, 50% of leiomyosarcomas, 22% of liposarcomas, 72% of malignant peripheral nerve sheath tumors, and 0% of the primitive neuroectodermal tumors were positive for CD10. Nearly half of the soft tissue sarcomas were found to express CD10. Stronger CD10 expression was found in high grade sarcomas.

Plasma cell granuloma of the thyroid.

We report two cases of thyroidal plasma cell granuloma. Both patients underwent surgical resection after presenting with painless neck swelling. Histopathologic examination of the specimens revealed plasmacytes infiltrating the thyroid parenchyma and immunohistochemical studies showed the polyclonal nature of the plasma cells. Plasma cell granuloma is a benign lesion and its appearance in the thyroid gland is extremely rare. Eleven prior cases with thyroid localization have been reported to date in the English literature. Nine of the plasma cell granuloma cases occurred in women, four in men (including the present cases). The clinicopathologic features and diagnostic difficulties of this rare entity are described, and its relation to inflammatory pseudotumor of other sites is discussed with a review of the literature.

Intravitreal Trovafloxacin against Experimental Staphylococcus epidermidis Endophthalmitis

This study was designed to test the effects of intravitreal trovafloxacin on an experimental rabbit model of Staphylococcus epidermidis endophthalmitis. Out of 26 rabbits, 22 were given intravitreal S. epidermidis (100,000 CFU). At 24 h, group 1 (8 rabbits) and, at 48 h, group 2 (8 rabbits) received 100 µg intravitreal trovafloxacin. Group 3 (6 rabbits) was used as inoculated but untreated controls. Four rabbits (group 4) were used as uninfected controls. Clinical scores were calculated at 24, 48 and 72 h. Microbiological and histopathological scorings were made. Microbiological analysis showed that trovafloxacin administered at 24 or 48 h significantly reduced the number of bacteria compared to the untreated group. We conclude that trovafloxacin applied at 24 or 48 h is effective against S. epidermidis endophthalmitis in this experimental rabbit model.

Correlation between prenatal ultrasound and fetal autopsy findings on urinary system anomalies terminated in the second trimester.

This prospective study was designed to compare ultrasound and autopsy findings on fetal urinary system malformations in second trimester terminations of pregnancy to evaluate the degree of agreement of such findings.

Sclerosing Extramedullary Hematopoietic Tumor

infiltration and fragility with petechiae and purpura, characteristically affecting the eyelids, beard area, and upper chest [2]. Purpura as the initial manifestation leading to the diagnosis of AL amyloidosis is relatively rare [3,4]. Therefore, cutaneous findings are valuable in making a diagnosis of this challenging disorder since early diagnosis before development of organ failure is essential for improving the prognosis of AL amyloidosis patients.

P19.06: Meckel Gruber syndrome: prenatal diagnosis and autopsy findings

Objectives: The aim of the study was to analyze prenatal sonographic anomalies detected in fetuses with Meckel Gruber syndrome (MGS) and to correlate these anomalies with autopsy findings. Methods: We examined fetal autopsy findings in 13 fetuses with MGS out of 142 second-trimester termination of pregnancy at a tertiary referral center. Results: Thirteen fetuses with MGS were analyzed. Twelve cases had classical clinic triad. One case had only cystic renal dysplasia and polydactyly. Occipital encephalocel was present in twelve cases and in one of them encephalocel was associated with Dandy Walker syndrome. The renal malformations characterized by bilateral, symmetrical enlargement of the kidneys with abdominal distension and lung compression. The renal parenchyma was diffusely cystic throughout the cortex and the medulla. Six cases showed ductal plate malformation of the liver with a variable degree of dilatation of the primitive biliary structures. Additional anomalies included micrognathia (n = 2), hypoplastic left ventricule (n = 1), chorangioma (n = 1), cleft palate (n = 1), and club foot (n = 1). Conclusions: Ultrasonographic findings of MGS allow diagnosis of the most cases. However autopsy may be valuable for confirmation of the diagnosis and to evaluate the recurrence risk in future pregnancies.