Tushar Hingorani

Transcorneal Permeation of l- and d-Aspartate Ester Prodrugs of Acyclovir: Delineation of Passive Diffusion Versus Transporter Involvement

PurposeThe aim of this study was to evaluate the contribution of amino acid transporters in the transcorneal permeation of the aspartate (Asp) ester acyclovir (ACV) prodrug.MethodsPhysicochemical characterization, solubility and stability of acyclovir l-aspartate (l-Asp-ACV) and acyclovir d-aspartate (d-Asp-ACV) were studied. Transcorneal permeability was evaluated across excised rabbit cornea.ResultsSolubility of l-Asp-ACV and d-Asp-ACV were about twofold higher than that of ACV. The prodrugs demonstrated greater stability under acidic conditions. Calculated pKa and logP values for both prodrugs were identical. Transcorneal permeability of l-Asp-ACV

Effect of Ion Pairing on In Vitro Transcorneal Permeability of a Δ9-Tetrahydrocannabinol Prodrug: Potential in Glaucoma Therapy

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Ocular Disposition of the Hemiglutarate Ester Prodrug of ∆ 9 -Tetrahydrocannabinol from Various Ophthalmic Formulations

was fourfold higher than d-Asp-ACV

Controlled release tablet formulation containing natural Δ9-tetrahydrocannabinol

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formulações injetáveis de aprepitante

and ACV