Tzu-Jen Kao

A Reconstruction Algorithm for Breast Cancer Imaging With Electrical Impedance Tomography in Mammography Geometry

The conductivity and permittivity of breast tumors are known to differ significantly from those of normal breast tissues, and electrical impedance tomography (EIT) is being studied as a modality for breast cancer imaging to exploit these differences. At present, X-ray mammography is the primary standard imaging modality used for breast cancer screening in clinical practice, so it is desirable to study EIT in the geometry of mammography. This paper presents a forward model of a simplified mammography geometry and a reconstruction algorithm for breast tumor imaging using EIT techniques. The mammography geometry is modeled as a rectangular box with electrode arrays on the top and bottom planes. A forward model for the electrical impedance imaging problem is derived for a homogeneous conductivity distribution and is validated by experiment using a phantom tank. A reconstruction algorithm for breast tumor imaging based on a linearization approach and the proposed forward model is presented. It is found that the proposed reconstruction algorithm performs well in the phantom experiment, and that the locations of a 5-mm-cube metal target and a 6-mm-cube agar target could be recovered at a target depth of 15 mm using a 32 electrode system

An Electrical Impedance Spectroscopy System for Breast Cancer Detection

This paper describes Rensselaers ACT 4 electrical impedance tomography system which has been developed for breast cancer detection. ACT 4 acquires electrical impedance data at a set of discrete frequencies in the range from 3.33 kHz to 1 MHz and can support up to 72 electrodes. The instrument applies either voltages or currents to all the electrodes simultaneously and measures the resulting currents and/or voltages. Radiolucent electrode arrays are applied to the compression plates of an x-ray mammography system for collecting impedance data in register with x-ray images. The analog front-end electronics are supported with a distributed digital system, including a computer, Digital Signal Processors (DSPs) and Field-Programmable Gate Arrays (FPGAs). A Microsoft Visual C/C++ -based user interface controls the system operation. The overall system architecture is presented as well as performance results.

A method for analyzing electrical impedance spectroscopy data from breast cancer patients

Research on freshly-excised malignant breast tissues and surrounding normal tissues in an in vitro impedance cell has shown that breast tumors have different conductivity and permittivity from normal or non-malignant tissues. This contrast may provide a basis for breast cancer detection using electrical impedance imaging. This paper describes a procedure for collecting electrical impedance spectroscopy data simultaneously and in register with tomosynthesis data from patients. We describe the methods used to analyze the data in order to determine if the electrodes are making contact with the breast of the patient. Canonical voltage patterns are applied and used to synthesize the data that would have resulted from constant voltage patterns applied to each of two parallel mammography plates. A type of Cole-Cole plot is generated and displayed from each of the currents measured on each of the electrodes for each of the frequencies (5, 10, 30, 100 and 300 kHz) of applied voltages. We illustrate the potential usefulness of these displays in distinguishing breast cancer from benign lesions with the Cole-Cole plots for two patients--one having cancer and one having a benign lesion--by comparing these graphs with electrical impedance spectra previously found by Jossinet and Schmitt in tissue samples taken from a variety of patients.

A 3D reconstruction algorithm for EIT using a handheld probe for breast cancer detection

A 3D reconstruction algorithm for electrical impedance tomography is presented for determining the distribution of electrical properties inside the body, given electrical measurements made on the surface. A linearized reconstruction algorithm using planar electrode arrays in a handheld probe geometry developed by Mueller et al (1999 IEEE Trans. Biomed. Eng. 46 1379-86) has been refined and extended in this paper. This algorithm is based on linearizing the conductivity about a constant value. We have extended the distance below the electrodes at which a target can be imaged by using a combination of two regularization schemes and a weighted mesh. An appropriate combination of Tikhonov and NOSER regularization produces satisfactory static images of a 2 cm cube placed 2 cm below the array, and difference images of a 1 cm cube 4 cm away from the array. The weighted mesh allows use of fixed regularization parameters for all depths of the target.

Robust Linearized Image Reconstruction for Multifrequency EIT of the Breast

Electrical impedance tomography (EIT) is a developing imaging modality that is beginning to show promise for detecting and characterizing tumors in the breast. At Rensselaer Polytechnic Institute, we have developed a combined EIT-tomosynthesis system that allows for the coregistered and simultaneous analysis of the breast using EIT and X-ray imaging. A significant challenge in EIT is the design of computationally efficient image reconstruction algorithms which are robust to various forms of model mismatch. Specifically, we have implemented a scaling procedure that is robust to the presence of a thin highly-resistive layer of skin at the boundary of the breast and we have developed an algorithm to detect and exclude from the image reconstruction electrodes that are in poor contact with the breast. In our initial clinical studies, it has been difficult to ensure that all electrodes make adequate contact with the breast, and thus procedures for the use of data sets containing poorly contacting electrodes are particularly important. We also present a novel, efficient method to compute the Jacobian matrix for our linearized image reconstruction algorithm by reducing the computation of the sensitivity for each voxel to a quadratic form. Initial clinical results are presented, showing the potential of our algorithms to detect and localize breast tumors.

A compensated radiolucent electrode array for combined EIT and mammography

Electrical impedance tomography (EIT), a non-invasive technique used to image the electrical conductivity and permittivity within a body from measurements taken on the bodys surface, could be used as an indicator for breast cancer. Because of the low spatial resolution of EIT, combining it with other modalities may enhance its utility. X-ray mammography, the standard screening technique for breast cancer, is the first choice for that other modality. Here, we describe a radiolucent electrode array that can be attached to the compression plates of a mammography unit enabling EIT and mammography data to be taken simultaneously and in register. The radiolucent electrode array is made by depositing thin layers of metal on a plastic substrate. The structure of the array is presented along with data showing its x-ray absorbance and electrical properties. The data show that the electrode array has satisfactory radiolucency and sufficiently low resistance.

A Versatile High-Permittivity Phantom for EIT

Phantoms are frequently used in medical imaging systems to test hardware, reconstruction algorithms, and the interpretation of data. This report describes and characterizes the use of powdered graphite as a means of adding a significant reactive component or permittivity to useful phantom media for electrical impedance imaging. The phantom materials produced have usable complex admittivity at the electrical impedance tomography (EIT) frequencies from a few kilohertz to 1 MHz, as measured by our EIT system (ACT4) and by a commercial bioimpedance analyzer (BIS 4000, Xitron). We have also studied a commercial ultrasound coupling gel, which is highly electrically conductive and semisolid but that permits objects to move within it. The mixture of agar-graphite and gel-graphite, increases in permittivity and conductivity are proportional to the graphite concentration. We also report the use of a porous polymer membrane to simulate skin. A thin layer of this membrane increased resistance and the characteristic frequency of the phantoms, providing a promising candidate to simulate the effect of skin and the layered structure of a breast or other anatomical structure. The graphite also provides a realistic level of ldquospecklerdquo in ultrasound images of the phantom, which may be useful in developing dual-mode imaging systems with ultrasound and the EIT.

Dynamic electrical impedance imaging of a chest phantom using the Kalman filter.

A dynamic complex impedance imaging technique is developed with the aid of the linearized Kalman filter (LKF) for real-time reconstruction of the human chest. The forward problem is solved by an analytical method based on the separation of variables and Fourier series. The inverse problem is treated as a state estimation problem. The nonlinear measurement equation is linearized about the best homogeneous impedivity value as an initial guess, and the impedivity distribution is estimated with the aid of the Kalman estimator. The Kalman gain matrix is pre-computed and stored off-line to minimize the on-line computational time. Simulation and phantom experiment are reported to illustrate the reconstruction performances in the sense of spatio-temporal resolution in a simplified geometry of the human chest.

An Implementation of CalderÓn's Method for 3-D Limited-View EIT

Mathematical interest in electrical impedance tomography has been strong since the publication of Calderons foundational paper. This paper introduced the idea of applying external voltage patterns to a medium such that, assuming that the medium is sufficiently close to a constant admittivity, the reconstruction can be accomplished directly by inverse Fourier transform. Motivated by Calderons method, we have developed a variant of the algorithm which is applicable to the case of measurement on only a part of the boundary and on discrete electrodes. Here we determine voltage or current patterns to apply to the electrodes which optimally approximate Calderons special functions in the interior. Furthermore, in three dimensions and higher, Calderons method allows each point in Fourier space to be computed in a multiplicity of ways. We show that by making use of the inherent redundancy in our measurements, we can significantly improve the quality of the static images produced by our algorithm.

A two-layered forward model of tissue for electrical impedance tomography

Electrical impedance tomography is being explored as a technique to detect breast cancer, exploiting the differences in admittivity between normal tissue and tumors. In this paper, the geometry is modeled as an infinite half space under a hand-held probe. A forward solution and a reconstruction algorithm for this geometry were developed previously by Mueller et al (1999 IEEE Trans. Biomed. Eng. 46 1379). In this paper, we present a different approach which uses the decomposition of the forward solution into its Fourier components to obtain the forward solution and the reconstructions. The two approaches are compared in terms of the forward solutions and the reconstructions of experimental tank data. We also introduce a two-layered model to incorporate the presence of the skin that surrounds the body area being imaged. We demonstrate an improvement in the reconstruction of a target in a layered medium using this layered model with finite difference simulated data. We then extend the application of our layered model to human subject data and estimate the skin and the tissue admittivities for data collected on the human abdomen using an ultrasound-like hand-held EIT probe. Lastly, we show that for this set of human subject data, the layered model yields an improvement in predicting the measured voltages of around 81% for the lowest temporal frequency (3 kHz) and around 61% for the highest temporal frequency (1 MHz) applied when compared to the homogeneous model.