Tzvi Tzfira

BotanyPlant Biology.ByAlison M.Smith, GeorgeCoupland, LiamDolan, NicholasHarberd, JonathanJones, CathieMartin, RobertSablowski,and, AbigailAmey.Garland Science. New York: Taylor & Francis.

tial for all living organisms, ranging from bacteria to humans. They act in a highly choreographed manner and alleviate topological problems in DNA by introducing transient breaks into one or both strands of the double helix. As a result of their actions, topoisomerases regulate levels of torsional stress in DNA, alleviate overwinding that occurs ahead of DNA tracking systems, and remove knots and tangles from the genetic material. Topoisomerases also play an important role in human health, and are the targets for some of the most commonly prescribed antibacterial and anticancer drugs currently in clinical use. Throughout this volume, Wang deftly “untangles” complex issues and presents them in an easily digestible form. He moves in a logical progression, starting with a brief overview of DNA topology and the need for topoisomerases. From there, he discusses the different classes of topoisomerases, how they work, and how they function in the cell. The book comes full circle with a further discussion of how DNA twisting impacts the functions of the genetic material and culminates with a primer on the use of topoisomerases to fight human disease. Untangling the Double Helix tells a highly stylized story that is marked by a clarity of thought and expression. Its goal is not to be a comprehensive volume that encompasses every aspect of topoisomerases. Rather, it serves as a well-written, often personal overview of the field. As a result, this engaging publication occupies a unique niche in the world of topoisomerases. It contains enough detail to make it a welcome addition to the bookshelves of investigators in the field, yet it is sufficiently accessible to serve as a superb introduction for those who are not yet acquainted with these fascinating enzymes. Neil Osheroff, Biochemistry and Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee