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Dive into the research topics where U. Löw is active.

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Featured researches published by U. Löw.


Journal of Cataract and Refractive Surgery | 2009

Spontaneous bilateral late-onset Descemet membrane detachment after successful cataract surgery.

Zisis Gatzioufas; F. Schirra; U. Löw; Sebastian Walter; Martin Lang; Berthold Seitz

We report the case of a 68-year-old man who developed bilateral Descemet membrane detachment (DMD) 4 weeks after successful cataract surgery and discuss the possible role of an underlying predisposition to DMD. Surgical intervention with gas injection in the anterior chamber resulted in excellent visual acuity restoration in the patient. To our knowledge, this is the first report of spontaneous bilateral DMD in the late postoperative period after cataract extraction.


Current Eye Research | 2008

Femtosecond Laser-Assisted Retinal Imaging and Ablation: Experimental Pilot Study

Matthias Hild; Matthias Krause; Iris Riemann; Pedro Mestres; Sergey Toropygin; U. Löw; Brückner K; Berthold Seitz; Christian P. Jonescu-Cuypers; Karsten König

Purpose: To investigate retinal imaging and ablation using femtosecond laser pulses. Materials and Methods: Two non-amplified near-infrared femtosecond lasers were used to irradiate porcine retinal specimens in vitro. The lasers were used for tissue removal as well as multiphoton laser scanning microscopy. Results: Ablation of the nerve fiber layer was performed at pulse energies of 1.0 nJ to 3.9 nJ. Control laser scanning images were acquired within seconds after irradiation. Specimens were additionally investigated with electron microscopy. Conclusions: Non-amplified femtosecond lasers may allow precise surgery controlled by fast high-resolution imaging of the target.


Current Eye Research | 2008

In Vitro Noncontact Intravascular Femtosecond Laser Surgery in Models of Branch Retinal Vein Occlusion

Sergey Toropygin; Matthias Krause; Iris Riemann; Matthias Hild; Pedro Mestres; Berthold Seitz; Elena Khurieva; Klaus W. Ruprecht; U. Löw; Zisis Gatzioufas; Karsten König

Purpose: To investigate intravenous femtosecond laser surgery in models of branch retinal vein occlusion. Materials and Methods: Non-amplified near infrared femtosecond laser was used to ablate polyamide sutures and human hairs inserted into the vascular lumina of porcine retinal veins in vitro. Specimens were subjected to multiphoton laser scanning microscopy and electron microscopy. Results: Regular laser cuts within sutures and hairs were detected with laser microscopy and electron microscopy. Neither laser microscopy nor histology revealed collateral damage of the vascular wall. Conclusions: Non-amplified femtosecond lasers may allow precise atraumatic non-contact intravenous retinal surgery controlled by high-resolution imaging of the target.


Ophthalmologe | 2012

Experimentelle Hornhautbildgebung und Hornhautchirurgie mit nicht verstärkten Femtosekundenlaserpulsen

C. Huss; Matthias Krause; U. Löw; Iris Riemann; Frank Stracke; Pedro Mestres; Berthold Seitz; Karsten König

BACKGROUND Non-amplified femtosecond laser was used to induce multiphoton effects for corneal tissue imaging and for tissue ablation. MATERIAL AND METHODS A non-amplified titanium-sapphire laser was coupled to a laser scanning microscope in order to examine human and porcine cornea. Tissue was subjected to imaging and lesions were created using identical optical pathways at pulse energies below 2 nJ. RESULTS Cellular components and the extracellular matrix were selectively imaged by applying autofluorescence and second harmonic generation at submicron resolution. Intrastromal linear scanning at higher power resulted in luminescent plasma along the scanning line. Lesion width decreased with increasing tissue depth and increased with increasing laser power at the target. Light microscopy showed intact stromal tissue around the area of the lesion. CONCLUSIONS High-resolution images as well as high precision tissue lesions were created in the cornea using low energy femtosecond laser pulses. Easy switching between tissue imaging and ablation seems to be suitable for diagnostic and therapeutic applications.


Ophthalmologe | 2012

[Experimental corneal imaging and corneal surgery with non-amplified femtosecond laser pulses].

C. Huss; Matthias Krause; U. Löw; Iris Riemann; Frank Stracke; Pedro Mestres; Berthold Seitz; Karsten König

BACKGROUND Non-amplified femtosecond laser was used to induce multiphoton effects for corneal tissue imaging and for tissue ablation. MATERIAL AND METHODS A non-amplified titanium-sapphire laser was coupled to a laser scanning microscope in order to examine human and porcine cornea. Tissue was subjected to imaging and lesions were created using identical optical pathways at pulse energies below 2 nJ. RESULTS Cellular components and the extracellular matrix were selectively imaged by applying autofluorescence and second harmonic generation at submicron resolution. Intrastromal linear scanning at higher power resulted in luminescent plasma along the scanning line. Lesion width decreased with increasing tissue depth and increased with increasing laser power at the target. Light microscopy showed intact stromal tissue around the area of the lesion. CONCLUSIONS High-resolution images as well as high precision tissue lesions were created in the cornea using low energy femtosecond laser pulses. Easy switching between tissue imaging and ablation seems to be suitable for diagnostic and therapeutic applications.


Ophthalmologe | 2012

Experimentelle Hornhautbildgebung und Hornhautchirurgie mit nicht verstärkten Femtosekundenlaserpulsen@@@Experimental corneal imaging and corneal surgery with non-amplified femtosecond laser pulses

C. Huss; Matthias Krause; U. Löw; Iris Riemann; Frank Stracke; Pedro Mestres; Berthold Seitz; Karsten König

BACKGROUND Non-amplified femtosecond laser was used to induce multiphoton effects for corneal tissue imaging and for tissue ablation. MATERIAL AND METHODS A non-amplified titanium-sapphire laser was coupled to a laser scanning microscope in order to examine human and porcine cornea. Tissue was subjected to imaging and lesions were created using identical optical pathways at pulse energies below 2 nJ. RESULTS Cellular components and the extracellular matrix were selectively imaged by applying autofluorescence and second harmonic generation at submicron resolution. Intrastromal linear scanning at higher power resulted in luminescent plasma along the scanning line. Lesion width decreased with increasing tissue depth and increased with increasing laser power at the target. Light microscopy showed intact stromal tissue around the area of the lesion. CONCLUSIONS High-resolution images as well as high precision tissue lesions were created in the cornea using low energy femtosecond laser pulses. Easy switching between tissue imaging and ablation seems to be suitable for diagnostic and therapeutic applications.


Ophthalmologe | 2010

Intraokulare hyperintense Struktur in der MRT bei einer Patientin mit Schwindel@@@Intraocular hyperintense structure in MRI in a female patient with vertigo

S. Jakob; Zisis Gatzioufas; U. Löw; A. Osvald; M. Lang; K. Brückner; Berthold Seitz

ZusammenfassungWir berichten über eine 77-jährige Patientin, bei der aufgrund länger bestehenden Schwindels zum Ausschluss einer intrakraniellen Raumforderung eine Magnetresonanztomographie des Schädels durchgeführt wurde. Die Untersuchung zeigte eine intraokulare hyperintense Struktur am linken Auge. Zum Ausschluss eines intraokularen Tumors wurde die Patientin in unserer Augenklinik vorgestellt. In der ophthalmologischen Untersuchung konnte die intraokulare Struktur in Zusammenschau mit der Anamnese als Residuen von Perfluordecalinbläschen entlarvt werden.AbstractWe present the case of a 77-year-old female patient who complained of dizziness. Consequently, a magnetic resonance imaging (MRI) examination was performed to rule out an intracranial tumor. The examination revealed an intraocular structure with signal hyperintensity in the left eye. The patient was referred to our clinic to screen for an intraocular tumor. Ophthalmological findings together with the medical history unmasked the “tumor” as residual perfluorodecaline vesicles.


Ophthalmologe | 2010

Intraokulare hyperintense Struktur in der MRT bei einer Patientin mit Schwindel

S. Jakob; Zisis Gatzioufas; U. Löw; A. Osvald; M. Lang; K. Brückner; Berthold Seitz

ZusammenfassungWir berichten über eine 77-jährige Patientin, bei der aufgrund länger bestehenden Schwindels zum Ausschluss einer intrakraniellen Raumforderung eine Magnetresonanztomographie des Schädels durchgeführt wurde. Die Untersuchung zeigte eine intraokulare hyperintense Struktur am linken Auge. Zum Ausschluss eines intraokularen Tumors wurde die Patientin in unserer Augenklinik vorgestellt. In der ophthalmologischen Untersuchung konnte die intraokulare Struktur in Zusammenschau mit der Anamnese als Residuen von Perfluordecalinbläschen entlarvt werden.AbstractWe present the case of a 77-year-old female patient who complained of dizziness. Consequently, a magnetic resonance imaging (MRI) examination was performed to rule out an intracranial tumor. The examination revealed an intraocular structure with signal hyperintensity in the left eye. The patient was referred to our clinic to screen for an intraocular tumor. Ophthalmological findings together with the medical history unmasked the “tumor” as residual perfluorodecaline vesicles.


Ophthalmologe | 2010

Intraocular hyperintense structure in MRI in a female patient with vertigo

S. Jakob; Zisis Gatzioufas; U. Löw; A. Osvald; M. Lang; K. Brückner; Berthold Seitz

ZusammenfassungWir berichten über eine 77-jährige Patientin, bei der aufgrund länger bestehenden Schwindels zum Ausschluss einer intrakraniellen Raumforderung eine Magnetresonanztomographie des Schädels durchgeführt wurde. Die Untersuchung zeigte eine intraokulare hyperintense Struktur am linken Auge. Zum Ausschluss eines intraokularen Tumors wurde die Patientin in unserer Augenklinik vorgestellt. In der ophthalmologischen Untersuchung konnte die intraokulare Struktur in Zusammenschau mit der Anamnese als Residuen von Perfluordecalinbläschen entlarvt werden.AbstractWe present the case of a 77-year-old female patient who complained of dizziness. Consequently, a magnetic resonance imaging (MRI) examination was performed to rule out an intracranial tumor. The examination revealed an intraocular structure with signal hyperintensity in the left eye. The patient was referred to our clinic to screen for an intraocular tumor. Ophthalmological findings together with the medical history unmasked the “tumor” as residual perfluorodecaline vesicles.


Graefes Archive for Clinical and Experimental Ophthalmology | 2009

Bilateral macular hole in a patient with chronic renal failure after recurrent deep vein thrombosis.

Zisis Gatzioufas; Matthias Krause; U. Löw; Berthold Seitz

Dear Editor, Macular hole (MH) is a clinical entity that usually occurs idiopathically in elderly individuals. Although many other causes of macular hole formation, such as trauma, proliferative diabetic retinopathy, epiretinal gliosis etc. are considered to represent important aetiological factors, the major pathophysiological mechanism implicated in the pathogenesis of MH remains the genesis of vitreoretinal tractions [1]. We would like to report an unusual case of bilateral idiopathic full-thickness macular hole (IFTMH) formation in a patient with chronic renal failure (CRF) after recurrent deep vein thrombosis (DVT), and discuss the potential aetiopathological relationship between these diseases. A 86-year-old woman presented with complaints of central blurry vision and gradual visual loss in both eyes for the previous 10 months. Her medical history included CRF, hypertension and chronic vein insufficiency. She had been receiving haemodialysis for the previous 2 years. Also, she was hospitalized four times within the previous 12 months for DVT of the calf veins in the right leg and treated with subcutaneous administration of 0.4 ml fractionated heparine (fraxiparinTM) twice a day and elevation of the right leg. Moreover, she reported two episodes of transient visual loss in the right eye (OD) and one episode in the left eye (OS) within the previous 12 months. Ophthalmic history included surgery for cataract senilis in both eyes, 12 years ago. Visual symptoms first occurred after the second DVT and progressed gradually with significant deterioration of the visual acuity. On ocular examination, the patient’s best corrected visual acuity was 0.05 OD and 0.1 OS. Slit-lamp examination disclosed no pathological findings. Ophthalmoscopy revealed bilateral IFTMH, an increased cup disc ratio of 0.6 OD and 0.5 OS and evidence of hypertensive retinopathy (Fig. 1). Optical coherence tomography showed IFTMH in both eyes (Fig. 2). The decision for a pars plana vitrectomy with membrane peeling was made. It is known that CRF may be sometimes involved in the pathogenesis of IFTMH. Cohen and Gass reported a fullthickness macular hole following an episode of hypertensive retinopathy in a young woman with CRF [2]. Later on, Kusaka et al. described a patient with bilateral giant IFTMH and CRF [3]. It has been suggested that ischemic injury from vasoconstriction weakening the fovea may lead to development of IFTMH in presence of CRF [2]. Moreover, Beatty et al. reported a patient with bilateral IFTMH resulting from septic embolization [4]. It is wellknown that DVT is often complicated by paradoxic embolization, resulting in cryptogenic strokes in patients with patent foramen ovale (PFO) [5]. Interestingly, cardiac ultrasound documented the presence of PFO in our patient. A PFO is an interatrial communication that might allow thromboemboli to pass from the right to the left side of the heart. PFO is anatomically open in about 25% of the general population, but remains functionally closed due to the high pressure in the left atrium [6]. Right-to-left shunt and subsequent paradoxical embolism does not occur under normal conditions unless the right atrial pressure exceeds that in the left, mostly as a result of pulmonary embolism [7]. Rare cases of right-to-left shunt in the absence of pressure gradient have also been described [8]. It has been documented that almost 40–50% of the patients with symptomatic DVT develop clinically silent pulmonary embolism [9, 10]. Moreover, the presence of PFO is Graefes Arch Clin Exp Ophthalmol (2009) 247:1003–1005 DOI 10.1007/s00417-008-0993-2

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