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Ulf-H. Dolling

Merck Sharp & Dohme Federal Credit Union

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Featured researches published by Ulf-H. Dolling.

Synthetic Communications | 2003

A Practical Synthesis of Lithium 3-Fluoropyridine-2-carboxylate

Khateeta M. Emerson; Robert D. Wilson; Michael S. Ashwood; Derek J. Kennedy; David Hands; Karel M. J. Brands; Ian F. Cottrell; Ulf-H. Dolling

Abstract A practical and efficient method for the preparation of lithium 3-fluoropyridine-2-carboxylate as well as its four regioisomer is described. 3-Fluoropyridine can be regioselectively lithiated on C-2 or C-4 depending on the reaction conditions. A quench procedure with carbon dioxide was developed which conveniently provides the lithium carboxylate in high yield and purity.

Organic Letters | 2001

A double ring closing metathesis reaction in the rapid, enantioselective synthesis of NK-1 receptor antagonists.

Debra J. Wallace; Jonathan M. Goodman; Derek J. Kennedy; Antony J. Davies; Cameron J. Cowden; Michael S. Ashwood; Ian F. Cottrell; Ulf-H. Dolling; Paul J. Reider

Journal of Organic Chemistry | 2006

Practical Asymmetric Synthesis of a γ-Secretase Inhibitor Exploiting Substrate-Controlled Intramolecular Nitrile Oxide−Olefin Cycloaddition

Jeremy P. Scott; Steven F. Oliver; Karel M. J. Brands; Sarah E. Brewer; Antony J. Davies; Andrew D. Gibb; David Hands; Stephen P. Keen; Faye J. Sheen; Robert A. Reamer; Robert Darrin Wilson; Ulf-H. Dolling

Organic Process Research & Development | 2008

Development of a Phase Transfer Catalyzed Asymmetric Synthesis for an Estrogen Receptor Beta Selective Agonist

Jeremy P. Scott; Michael S. Ashwood; Karel M. J. Brands; Sarah E. Brewer; Cameron J. Cowden; Ulf-H. Dolling; Khateeta M. Emerson; Andrew D. Gibb; Adrian Goodyear; Steven F. Oliver; Gavin W. Stewart; Debra J. Wallace

Organic Process Research & Development | 2006

The Expedient Synthesis of 4,2‘-Difluoro-5‘-(7-trifluoromethyl- imidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile, a GABA α2/3 Agonist

Mark Cameron; Bruce S. Foster; Joseph E. Lynch; Yao-Jun Shi; Ulf-H. Dolling

Journal of Organic Chemistry | 2005

Practical synthesis of the new carbapenem antibiotic ertapenem sodium.

J. Michael Williams; Karel M. J. Brands; Renato T. Skerlj; Ronald B. Jobson; George Marchesini; Karen M. Conrad; Brenda Pipik; Kimberly A. Savary; Fuh-Rong Tsay; Peter G. Houghton; D. Richard Sidler; Ulf-H. Dolling; Lisa DiMichele; Thomas J. Novak

Journal of Organic Chemistry | 2006

Synthesis of a NO-Releasing Prodrug of Rofecoxib

F. Conrad Engelhardt; Yao-Jun Shi; Cameron J. Cowden; David A. Conlon; Brenda Pipik; George Zhou; James M. McNamara; Ulf-H. Dolling

Journal of Organic Chemistry | 1998

PRACTICAL SYNTHESIS OF ANTI-METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) CARBAPENEM L-742,728

Nobuyoshi Yasuda; Mark A. Huffman; Guo-Jie Ho; Lyndon C. Xavier; Chunhua Yang; Khateeta M. Emerson; Fuh-Rong Tsay; Yulan Li; Michael H. Kress; Dale L. Rieger; Sandor Karady; Paul Sohar; Newton L. Abramson; Ann E Decamp; David J. Mathre; Alan W. Douglas; Ulf-H. Dolling; Edward J. J. Grabowski; Paul J. Reider

Journal of Organic Chemistry | 2002

Efficient One-Pot Synthesis of the 2-Aminocarbonylpyrrolidin-4-ylthio-Containing Side Chain of the New Broad-Spectrum Carbapenem Antibiotic Ertapenem

Karel M. J. Brands; Ronald B. Jobson; Karen M. Conrad; J. Michael Williams; Brenda Pipik; Mark Cameron; Antony J. Davies; Peter G. Houghton; Michael S. Ashwood; Ian F. Cottrell; Robert A. Reamer; Derek J. Kennedy; Ulf-H. Dolling; Paul J. Reider

Journal of Organic Chemistry | 1998