Ulku Gul
Erciyes University
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Publication
Featured researches published by Ulku Gul.
Journal of Pediatric Endocrinology and Metabolism | 2015
Deniz Okdemir; Nihal Hatipoglu; Himmet Haluk Akar; Ulku Gul; Leyla Akin; Fulya Tahan; Selim Kurtoglu
Abstract Gonadotropin-releasing hormone analogues are used in the treatment of prostate cancer, breast cancer, endometriosis, and uterine leiomyomas in adults and often in the treatment of precocious puberty in children. Many adverse effects have been reported for gonadotropin-releasing hormone analogues, but anaphylaxis is rarely reported as an adverse effect. Frequent cross-reactions, particularly during childhood, and diversity of the time of onset of anaphylactic manifestations complicate the diagnosis. A patient who exhibited anaphylactic allergic reactions to two different agents used in the treatment of central precocious puberty presented here because the case has an atypical course and is the first in the literature.
Journal of Clinical Research in Pediatric Endocrinology | 2015
Sabriye Korkut; Emir Gökalp; Ahmet Ozdemir; Selim Kurtoglu; Şafak Demirtaş; Ulku Gul; Osman Baştuğ
Pseudohypoaldosteronism (PHA) is defined as a state of resistance to aldosterone, a hormone crucial for electrolyte equilibrium. The genetically transmitted type of PHA is primary hypoaldosteronism. Secondary hypoaldosteronism develops as a result of hydronephrosis or hydroureter. PHA patients suffer from severe hyponatremia and a severe clinical condition due to severe loss of salt can be encountered in the neonatal period. Dermal findings in the form of miliaria rubra can also develop in these patients. With the loss of salt, abnormal accumulation of sebum in the eye due to a defect in the sodium channels can also occur. In this paper, a case of PHA in a newborn showing typical dermatological and ophthalmological findings is presented.
Pediatric Diabetes | 2018
H Demirbilek; Nihal Hatipoglu; Ulku Gul; Z Uzan Tatli; Sian Ellard; Sarah E. Flanagan; E De Franco; Selim Kurtoglu
The basic helix‐loop‐helix (bHLH) transcription factor, neuronal differentiation 1 (NEUROD1) (also known as BETA2) is involved in the development of neural elements and endocrine pancreas. Less than 10 reports of adult‐onset non‐insulin‐dependent diabetes mellitus (NIDDM) due to heterozygous NEUROD1 mutations and 2 cases with permanent neonatal diabetes mellitus (PNDM) and neurological abnormalities due to homozygous NEUROD1 mutations have been published. A 13 year‐old female was referred to endocrine department due to hyperglycemia. She was on insulin therapy following a diagnosis of neonatal diabetes mellitus (NDM) at the age of 9‐weeks but missed regular follow‐up. Parents are second cousin. There was a significant family history of adult onset NIDDM including patients father. Auxological measurements were within normal ranges. On laboratory examination blood glucose was 33.2 mmol/L with undetectable c‐peptide and glycosylated hemoglobin level of 8.9% (73.8 mmol/mol). She had developed difficulty in walking at the age of 4 years which had worsened over time. On further evaluation, a diagnosis of visual impairment, mental retardation, ataxic gait, retinitis pigmentosa and sensory‐neural deafness were considered. Cranial magnetic resonance imaging revealed cerebellar hypoplasia. Molecular genetic analysis using targeted next generation sequencing detected a novel homozygous missense mutation, p.Ile150Asn(c.449T>A), in NEUROD1. Both parents and 2 unaffected siblings were heterozygous for the mutation. We report the third case of PNDM with neurological abnormalities caused by homozygous NEUROD1 mutation, the first caused by a missense mutation. Heterozygous carriers of the p.Ile150Asn mutation were either unaffected or diagnosed with diabetes in adulthood. It is currently unclear whether the NEUROD1 heterozygous mutation has contributed to diabetes development in these individuals.
Pediatric Dermatology | 2017
Zeynep Uzan Tatlı; Ulku Gul; Nihal Hatipoglu; Selim Kurtoglu
Scrotal hair is a clinical condition that occurs rarely in infancy. Its prevalence is not known. We present a retrospective analysis of six patients referred to our pediatric endocrinology clinic. Except for scrotal hair development, all physical examinations were normal. Underlying pathologic hyperandrogenism was excluded in each case. Clinical regression was observed in all four infants with documented follow‐up visits. Scrotal hair in infancy is not well known to most pediatricians and dermatologists and can cause parental anxiety. Our cases are typical of the benign course of isolated scrotal hair.
Archive | 2016
Selim Kurtoglu; Nihal Hatipoglu; Ulku Gul; Zeynep Uzan Tatlı; Leyla Akin; Mustafa Kendirci
Archive | 2016
Mustafa Kendirci; Gül Yücel; Ulku Gul
55th Annual ESPE | 2016
Ulku Gul; Bahadir Samur; Zeynep Uzan Tatlı; Nihal Hatipoglu; Mustafa Kendirci; Selim Kurtoglu
55th Annual ESPE | 2016
Nihal Hatipoglu; Huseyin Demirbilek; Ulku Gul; Zeynep Uzan Tatlı; Sarah Flanagan; Sian Ellard; Franco Elisa De; Selim Kurtoglu
55th Annual ESPE | 2016
Mehmet Adnan Ozturk; Ahmet Ozdemir; Ulku Gul; Nihal Hatipoglu; Sabriye Korkut; Mahir Ceylan; Selim Kurtoglu
Archive | 2015
Deniz Okdemir; Ulku Gul; Leyla Akin; Nihal Hatipoglu; Mustafa Kendirci; Selim Kurtoglu