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Ulrich Iserloh

Merck & Co.

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Publication

Featured researches published by Ulrich Iserloh.

Bioorganic & Medicinal Chemistry Letters | 2015

Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors

Brian A. McKittrick; John P. Caldwell; Thomas Bara; George Boykow; Madhu Chintala; John W. Clader; Michael Czarniecki; Brandy Courneya; Ruth Duffy; Linda Fleming; Rachel Giessert; William J. Greenlee; Charles R. Heap; Liwu Hong; Ying Huang; Ulrich Iserloh; Hubert Josien; Tanweer Khan; Walter A. Korfmacher; Xian Liang; Robert Mazzola; Soumya Mitra; Kristina Moore; Peter Orth; Murali Rajagopalan; Sudipta Roy; Samuel A. Sakwa; Corey Strickland; Henry M. Vaccaro; Johannes Voigt

The development of renin inhibitors with favorable oral pharmacokinetic profiles has been a longstanding challenge for the pharmaceutical industry. As part of our work to identify inhibitors of BACE1, we have previously developed iminopyrimidinones as a novel pharmacophore for aspartyl protease inhibition. In this letter we describe how we modified substitution around this pharmacophore to develop a potent, selective and orally active renin inhibitor.

Archive | 2012

Heterocyclic aspartyl protease inhibitors

Zhaoning Zhu; Brian Mckittrick; Zhong-Yue Sun; Yuanzan C. Ye; Johannes H. Voight; Corey O. Strickland; Elizabeth M. Smith; Andrew Stamford; William J. Greenlee; Robert Mazzola; John P. Caldwell; Jared N. Cumming; Lingyan Wang; Yusheng Wu; Ulrich Iserloh; Xiaoxiang Liu; Tao Guo; Thuy X. E. Le; Kurt W. Saionz; Suresh D. Babu; Rachael C. Hunter; Michelle L. Morris; Huizhong Gu; Gang Qian; Dawit Tadesse; Ying Huang; Guoqing Li; Jianping Pan; Jeffrey Misiaszek; Gaifa Lai

Bioorganic & Medicinal Chemistry Letters | 2012

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

Jared N. Cumming; Elizabeth M. Smith; Lingyan Wang; Jeffrey Misiaszek; James Durkin; Jianping Pan; Ulrich Iserloh; Yusheng Wu; Zhaoning Zhu; Corey Strickland; Johannes Voigt; Xia Chen; Matthew E. Kennedy; Reshma Kuvelkar; Lynn Hyde; Kathleen Cox; Leonard Favreau; Michael Czarniecki; William J. Greenlee; Brian A. McKittrick; Eric M. Parker; Andrew W. Stamford

Archive | 2010

Iminothiadiazine dioxide compounds as BACE inhibitors, compositions and their use

Jack D. Scott; Andrew W. Stamford; Eric J. Gilbert; Jared N. Cumming; Ulrich Iserloh; Jeffrey Misiaszek; Guoqing Li

Archive | 2004

Cyclic amine bace-1 inhibitors having a benzamide substituent

Jared N. Cumming; Ulrich Iserloh; Andrew W. Stamford; Corey Strickland; Johannes H. Voigt; Yusheng Wu; Ying Huang; Yan Xia; Samuel Chackalamannil; Tao Guo; Douglas W. Hobbs; Thuy X. H. Le; Jeffrey F. Lowrie; Kurt W. Saionz; Suresh D. Babu

Archive | 2009

Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as bace-1 inhibitors, compositions, and their use

Andrew W. Stamford; Zhaoning Zhu; Mihirbaran Mandal; Yusheng Wu; Jared N. Cumming; Xiaoxiang Liu; Guoqing Li; Ulrich Iserloh

Archive | 2010

Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions, and their use

Ulrich Iserloh; Andrew W. Stamford; Jared N. Cumming

Journal of Medicinal Chemistry | 2016

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

Jack D. Scott; Sarah W. Li; Andrew Brunskill; Xia Chen; Kathleen Cox; Jared N. Cumming; Eric J. Gilbert; Robert A. Hodgson; Lynn A. Hyde; Qin Jiang; Ulrich Iserloh; Irina Kazakevich; Reshma Kuvelkar; Hong Mei; John Meredith; Jeffrey Misiaszek; Peter Orth; Lana M. Rossiter; Meagan Slater; Julie A. Stone; Corey O. Strickland; Johannes H. Voigt; Ganfeng Wang; Hongwu Wang; Yusheng Wu; William J. Greenlee; Eric M. Parker; Matthew E. Kennedy; Andrew Stamford

Archive | 2014

C5-spiro iminothiadiazine dioxides as bace inhibitors

Jared N. Cumming; Jack D. Scott; Andrew W. Stamford; Ulrich Iserloh; Santhosh Francis Neelamkavil; Pengcheng Patrick Shao; Jonathan E. Wilson

Archive | 2013

Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use

Eric J. Gilbert; Jared N. Cumming; Andrew W. Stamford; Younong Yu; Jack D. Scott; Ulrich Iserloh; Lingyan Wang; John P. Caldwell

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Andrew Stamford

Schering-Plough

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Yusheng Wu

Schering-Plough

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Jared N. Cumming

Johns Hopkins University

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Jack D. Scott

Schering-Plough

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Jared N. Cumming

Johns Hopkins University

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Andrew W. Stamford

Merck

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Corey Strickland

Merck

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Johannes H. Voigt

National Institutes of Health

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Eric J. Gilbert

Schering-Plough

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Guoqing Li

Schering-Plough

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