Ulrich Sprengard
University of Mainz
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Publication
Featured researches published by Ulrich Sprengard.
Tetrahedron | 1995
Gerhard Kretzschmar; Ulrich Sprengard; Horst Kunz; Eckart Bartnik; Wolfgang Schmidt; Alexander Toepfer; Brigitte Horsch; Manfred Krause; Dirk Dr Seiffge
Abstract Trivalent sialyl Lewis-X ligands 6–8 anchored onto flexible templates have been synthesized and evaluated as inhibitors of E-selectin and P-selectin mediated cell adhesion in cell culture assays and in vivo. Biological activities in vitro correlated with spacer length and lead to ligands with 3-fold (E-selectin) and 5-fold (P-selectin) improved receptor binding avidity per single tetrasaccharide moiety.
Bioorganic & Medicinal Chemistry Letters | 1996
Ulrich Sprengard; Horst Kunz; Christoph Dr. Hüls; Wolfgang Schmidt; Dirk Dr Seiffge; Gerhand Kretzshmar
Abstract Novel sialyl Lewis X conjugates have been synthesized and evaluated as inhibitors of E- and P-selectin mediated cell adhesion in cell culture assays. The most potent conjugate in the static inhibition assays exhibited a significant and dose-dependent pharmacological potency as inhibitor of the edotoxin-induced leukocyte adhesion to the endothelium of postcapillary venules in rats.
Angewandte Chemie | 1996
Ulrich Sprengard; Manfred Schudok; Wolfgang Schmidt; Gerhard Kretzschmar; Horst Kunz
Angewandte Chemie | 1994
Wilhelm Stahl; Ulrich Sprengard; Gerhard Kretzschmar; Horst Kunz
Angewandte Chemie | 1995
Ulrich Sprengard; Gerhard Kretzschmar; Eckart Bartnik; Christoph Dr. Hüls; Horst Kunz
Archive | 1995
Gerhard Kretzschmar; Wolfgang Schmidt; Ulrich Sprengard; Eckart Bartnik; Dirk Dr Seiffge; Horst Kunz
Angewandte Chemie | 1995
Ulrich Sprengard; Gerhard Kretzschmar; Eckart Bartnik; Christoph Dr. Hüls; Horst Kunz
Angewandte Chemie | 1994
Wilhelm Stahl; Ulrich Sprengard; Gerhard Kretzschmar; Horst Kunz
Archive | 1996
Wolfgang Schmidt; Ulrich Sprengard; Gerhard Kretzschmar; Horst Kunz
Angewandte Chemie | 1996
Ulrich Sprengard; Manfred Schudok; Wolfgang Schmidt; Gerhard Kretzschmar; Horst Kunz
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