Uri Rozovski

Preventing Sudden Death of Athletes With Electrocardiographic Screening: What Is the Absolute Benefit and How Much Will it Cost?

OBJECTIVES This study sought to estimate the costs of a national electrocardiographic (ECG) screening of athletes in the United States and the number of lives that would be saved by that program. BACKGROUND A single study from Italy suggests that mandatory ECG screening of athletes reduces their risk of sudden cardiac death. Based on that study, ECG screening of athletes is endorsed by the European Society of Cardiology, though not by the American Heart Association. The widespread application of ECG screening remains controversial because the absolute reduction of sudden cardiac death risk provided, and its economic ramifications, have not been studied in detail. METHODS A cost-projection model was based on the Italian study, replicating its data in terms of athlete characteristics and physician performance. The size of the screening-eligible population was estimated from data provided by the National Collegiate Athletic Association and the National Federation of State High School Associations. The costs of diagnostic tests were obtained from Medicare reimbursement rates. RESULTS A 20-year program of ECG screening of young competitive athletes in the United States would cost between

Viewpoint and CommentaryPreventing Sudden Death of Athletes With Electrocardiographic Screening: What Is the Absolute Benefit and How Much Will it Cost?

51 and

Signal transducer and activator of transcription (STAT)-3 regulates microRNA gene expression in chronic lymphocytic leukemia cells

69 billion and could be expected to save 4,813 lives. Accordingly, the cost per life saved is likely to range between

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells

10.6 and

Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells

14.4 million. CONCLUSIONS Our cost-projection model suggests that replicating the Italian strategy of ECG screening in the United States would result in enormous costs per life saved.

Outcomes of Patients With Chronic Lymphocytic Leukemia and Richter's Transformation After Transplantation Failure

OBJECTIVES This study sought to estimate the costs of a national electrocardiographic (ECG) screening of athletes in the United States and the number of lives that would be saved by that program. BACKGROUND A single study from Italy suggests that mandatory ECG screening of athletes reduces their risk of sudden cardiac death. Based on that study, ECG screening of athletes is endorsed by the European Society of Cardiology, though not by the American Heart Association. The widespread application of ECG screening remains controversial because the absolute reduction of sudden cardiac death risk provided, and its economic ramifications, have not been studied in detail. METHODS A cost-projection model was based on the Italian study, replicating its data in terms of athlete characteristics and physician performance. The size of the screening-eligible population was estimated from data provided by the National Collegiate Athletic Association and the National Federation of State High School Associations. The costs of diagnostic tests were obtained from Medicare reimbursement rates. RESULTS A 20-year program of ECG screening of young competitive athletes in the United States would cost between

Preoperative imaging to predict intraoperative changes in tumor-to-corticospinal tract distance: An analysis of 45 cases using high-field intraoperative magnetic resonance imaging

51 and

The safety of conception occurring shortly after methotrexate treatment of an ectopic pregnancy.

69 billion and could be expected to save 4,813 lives. Accordingly, the cost per life saved is likely to range between

Signal Transducer and Activator of Transcription-3 Induces MicroRNA-155 Expression in Chronic Lymphocytic Leukemia

10.6 and

Incidence of and risk factors for involvement of the central nervous system in acute myeloid leukemia

14.4 million. CONCLUSIONS Our cost-projection model suggests that replicating the Italian strategy of ECG screening in the United States would result in enormous costs per life saved.