Uruwan Yamborisut

SEANUTS: the nutritional status and dietary intakes of 0.5–12-year-old Thai children

In the present study, we investigated nutritional status and health-related factors in a multistage cluster sample of 3119 Thai urban and rural children aged 0·5-12·9 years. In a subsample, blood samples were collected for the measurement of Hb, transferrin receptor, vitamin A and vitamin D concentrations. The prevalence of stunting and underweight was higher in rural children than in urban children, whereas the wasting rate was similar in both rural and urban areas. Among children aged 3·0-5·9 years, the prevalence of overweight was significantly higher in urban areas than in rural areas and so was the obesity rate in children aged 6·0-12·9 years. Protein intakes of all age groups were relatively high in both the areas. Intakes of Ca, Fe, Zn and vitamin C were significantly higher in urban areas than in rural areas. The prevalence of anaemia in rural areas was twice as high as that in urban areas, particularly in infants and young children. However, the prevalence of Fe-deficiency anaemia was similar in both urban and rural areas. While the prevalence of vitamin A deficiency (by serum retinol cut-off < 0·7 μmol/l) seemed to be very low, vitamin A insufficiency (by serum retinol cut-off < 1·05 μmol/l) was more prevalent (29·4-31·7%) in both the areas. The prevalence of vitamin D insufficiency ranged between 27·7 and 45·6% among the children. The present study indicates that the double burden of malnutrition is still a major public health problem in Thailand. Further studies need to explore the associated risk factors for these nutrient deficiencies. Effective strategies and actions are needed to tackle the nutritional problems in Thai children.

Long-term supplementation of high pigmented rice bran oil (Oryza sativa L.) on amelioration of oxidative stress and histological changes in streptozotocin-induced diabetic rats fed a high fat diet; Riceberry bran oil.

Diabetes is a serious health problem. Searching for alternative natural antioxidants is considered important strategy to manage diabetes. This study evaluated the effect of Riceberry bran oil (RBBO) supplementation on oxidative stress and organ histology in streptozotocin-induced diabetic rats fed a high fat (HF) diet. Adult male Sprague-Dawley rats with hyperglycemia were divided into four groups: DM group fed a HF diet alone; DMRL group fed a HF diet and 5% RBBO; DMRM group fed a HF diet and 7.5% RBBO; DMRH group fed a HF diet and 15% RBBO. Normal rats were used as normal control and were divided into NC and NR group fed a normal diet containing either 5% corn oil or 5% RBBO, respectively. After 12 weeks, RBBO significantly decreased malondialdehyde and restored superoxide dismutase, catalase, glutathione peroxidase, coenzyme Q(10) and ORAC levels in diabetic rats. RBBO additionally improved the regenerative changes of the pancreas, kidneys, heart and liver. These findings indicate that pigmented RBBO could provide beneficial effect on diabetes by decreasing oxidative stress and recovering organ histology.

Leptin, Soluble Leptin Receptor, Lipid Profiles, and LEPR Gene Polymorphisms in Thai Children and Adolescents

OBJECTIVE To evaluate the relationships between leptin, soluble leptin receptor, lipid profiles, and LEPR gene polymorphisms in child and adolescent Thai subjects. DESIGN Cross-sectional study of Thai children and adolescents. SUBJECTS 116 male and 65 female at risk for overweight/overweight child and adolescent Thai subjects, and 33 male and 62 female healthy child and adolescent Thai subjects (age: 5-19 years). MEASUREMENTS Leptin levels, soluble leptin receptor levels, lipid profiles, LEPR gene polymorphisms. RESULTS Significantly higher levels of cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), and leptin levels were observed in at risk for overweight/overweight group. On the other hand, high-density lipoprotein cholesterol (HDL-C) and soluble leptin receptor levels were significantly lower in the same group. Serum soluble leptin receptor levels were significantly negatively correlated with leptin. The at risk for overweight/overweight subjects with the Lys656Lys homozygous wild type LEPR gene had significantly higher cholesterol and LDL-C levels than those with Lys656Asn heterozygous and Asn656Asn homozygous mutant type. In contrast, subjects with Lys656Lys homozygous wild type had significantly lower leptin levels than those with Lys656Asn heterozygous and Asn656Asn homozygous mutant type. There was a statistically significant association between body mass index (BMI) and hyperleptinemia (odds ratio; OR = 2.49, p = 0.000) and females had more increased risk of hyperleptinemia than males (OR = 15.74, p = 0.004) in adolescent Thai subjects. CONCLUSION The present study is the first report of Lys656Asn polymorphism of the LEPR gene associated with cholesterol, LDL-C, and leptin levels in Thai children and adolescents. Serum leptin levels were significantly higher in the at risk for overweight/overweight. In contrast, there were significantly lower soluble leptin receptor levels in the same group. In addition, there was a statistically significant association between BMI, sex, and hyperleptinemia in adolescent Thai subjects.

Waist circumference and body fat distribution indexes as screening tools for the overweight and obesity in Thai preschool children

SUMMARY BACKGROUND Evidence shows that waist circumference (WC) is one reliable index to predict abdominal obesity in children. This study aims to examine the relationship of WC to other anthropometric indexes and to determine the ability of WC as obesity screening tool. SUBJECTS 811, 5-6 years old children in Saraburi province, central region of Thailand. METHODS Anthropometric measurements were performed in children; 406 boys and 405 girls. WC measurement was performed at the umbilicus level. Subcutaneous skinfold was measured on subscapular, suprailiac and abdominal regions. Total body fat was measured with bioelectrical impedance analyzer. Receiver operating characteristic (ROC) analysis was employed to determine WC cut-offs for predicting obesity in children. RESULTS WC highly correlated with weight-for-height Z-score (WHZ) (r = 0.92-0.94, p = 0.01), body mass index (BMI) (r = 0.95-0.96, p = 0.01), trunk skinfold (r = 0.92-0.93, p = 0.01) and total body fat (r = 0.94-0.95, p = 0.01) for both genders. Based on Thai national reference, the optimal WC cut-offs for predicting obesity were 59.6 cm for boys and 60.5 cm for girls. When IOTF-BMI was employed as reference, WC thresholds were 64.4 cm for boys and 63.1 cm for girls. The latter WC cut-offs provided the slightly underestimated obesity prevalence compared with national reference. CONCLUSION The strongly positive correlation between WC and weight-height based index and between WC and body fat in Thai preschool children suggests that WC should be the additional index for obesity screening in young children. Further study needs to explore the association between the increased WC and other adverse health outcomes.

Nutrifit programme to improve health-related fitness among young Thai schoolchildren.

A Nutrifit programme, consisting of a nutrition education and physical training model, was developed by modifying an established Fitnessgram as a tool. the programme was tested among 514 schoolchildren aged eight to nine years who were enrolled in two provincial government schools (A and B) and two private schools (C and D) in the Bangkok Metropolitan Area. Health-related fitness tests using the Fitnessgram were administered in all four schools, followed by the Nutrifit programme intervention in schools B and D. the intervention included 10 nutrition and physical training education sessions during the regular physical education classes. During the seven-month programme period, though the nutritional status of children did not show a significant change, improvement in health-related fitness tests was noted in both non-intervened and intervened schools. It is recommended that the Nutrifit programme be incorporated into the school curriculum as a measure of nutrition and fitness aimed at health promotion and disease prevention.

Waist Circumference Measures and Application to Thai Children and Adolescents

The prevalence of childhood obesity has been increasing worldwide. Assessment of changing trends in nutritional and health status of the child population could be achieved using accurate and reliable body composition techniques. Waist circumference is a simple anthropometric measure that is useful for the detection of abdominal obesity which reflects the sum of subcutaneous and visceral adipose tissues in the trunk region. Research evidence shows that waist circumference is highly correlated with weight-for-height and body mass index. Waist circumference is also a good predictor of cardiovascular risk factors. Measurement of waist circumference can be performed at different sites of the trunk region and the measurement technique requires a standardized procedure. Reference data of percentile distributions of waist circumference among children and adolescents are now available in many countries, including Thailand. Waist circumference cut-off can be an advantageous tool for a large-scale screening of children who are at risk for overnutrition and for tracking child growth. Future studies need to address the universal waist circumference benchmark and the application of waist circumference as well as weight-to-height ratio for growth monitoring and public health intervention program towards promoting a healthy child population.

Parental feeding practice is associated with child’s body mass index in Thai school-aged children: A case study in Don Tum district, Nakhon Pathom, Thailand

Purpose Parental feeding practice (PFP) plays an important role in child’s eating behavior and weight status, but less information is available about its role in the Thai family setting. The purpose of this paper is to examine the influence of PFP on child’s gender and body mass index (BMI). Design/methodology/approach Participants included 227 parents-child dyads from the suburban area of Nakhon Pathom province, Thailand. Children aged 9-12 years and parents who were either child’s mother, father or grandfather/grandmother were enrolled in the study. Body weight, height, waist circumference and body fat were measured in all children. Eating behavior of each child was assessed by using child’s eating questionnaire. Parents also provided their feeding practices in child feeding questionnaires. Information on household food security was also obtained from children’s parents. Findings There was significant difference in eating behaviors and home environment between child’s genders. For child’s eating behavior, mean total eating scores of girls were significantly greater (p=0.002) than that of boys and that the inappropriate home environment was more found in families of boys than girls. Regarding feeding practice, parents used more food restriction (p=0.008) and monitoring on child’s eating (p=0.042) in girls than boys. Parents put more pressure to eat on the normal weight than obese children (p=0.001). Regression analysis revealed that, apart from parental BMI and household income, PFPs have a significant impact (15.6 percent explained variance) on child’s BMI. Originality/value This study highlights the importance of being aware of child’s gender and weight status when feeding practices were provided to them. Nutrition education for parents should take account for parents’ perceptions and concerns as well as the modification of feeding practices to improve children’s eating behaviors.

Relationship between α-MSH, soluble leptin receptor, MC4R polymorphism and BMI in Thai children and adolescents

In order to evaluate the mechanism of disturbance of melanocortin signaling in different groups of Thai children and adolescents classified according to body mass index (BMI) pe rcentile for age by The Centers for Disease Control and Prevention (CDC) growth charts, and �-melanocortin stimulating hormone (�-MSH), soluble leptin receptor and melanocortin 4 receptor (MC4R) polymorphism were studied. 149 male and 127 female children and adolescent Thai subjects with age range between 5-19 years were selected. Statistically significant differ ence of serum leptin receptor concentration between under weight (< 5th percentile), possible at risk for underweight (between 5th and 15th percentile), probably healthy (between 15th and 85th percentile); at risk for overweight (between the 85th and 95th percentile) and overweight (over the 95th percentile) were found. The levels of �-MSH were not significantly different when comparing the gro ups. Heterozygous of MC4R polymorphism (Val103Ile) were found in underweight, possible at risk for underweight and probably healthy group which might have been the cause of lower BMI for age even they have had normal serum �-MSH concentration. Using the logistic regression analysis, the group of risk for being overweight and overweight was statistically significant with �-MSH. This study supported a positive correlation between �-MSH and BMI with ages of Thai children and adolescents group.

Hypercholesterolemia in Thai primary school children: Relation to maternal and nutritional factors

Background: There is evidence to show that atherosclerosis can occur in young children and that elevated total cholesterol and low density lipoprotein cholesterol concentrations are risk factors for atherosclerosis. The aim of the present cross‐sectional study was to investigate the influence of maternal and nutritional factors on blood cholesterol in primary school children.