Ute Lange
University of Jena
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Publication
Featured researches published by Ute Lange.
Haemostasis | 1999
Ute Lange; Wieland Keilholz; Günter A. Schaub; Hellmut Landmann; Fritz Markwardt; Götz Nowak
From the bloodsucking bug Dipetalogaster maximus, a protein with anticoagulant activity was isolated and biochemically characterized. The isolated protein, named dipetalogastin, possesses an average molecular mass of 11.8 kD. Its N-terminal sequence shows homology to rhodniin, a thrombin inhibitor isolated from the bug Rhodnius prolixus. The in vitro anticoagulant activity of dipetalogastin occurs via the inhibition of thrombin. The anticoagulant and thrombin inhibitory potency of dipetalogastin is comparable to that of recombinant hirudin. Its specific thrombin inhibitory activity is 9,300 antithrombin units/mg protein. Dipetalogastin forms only 1:1 molar complexes with thrombin. It is a tight-binding inhibitor of thrombin possessing a dissociation constant of 125 fM. It does not inhibit factor Xa or α-chymotrypsin and only weakly inhibits trypsin.
FEBS Journal | 2000
Rosario Maida; Jürgen Krieger; Therese Gebauer; Ute Lange; Gunde Ziegelberger
FEBS Journal | 1999
Katrin Mende; Olga Petoukhova; Valentina Koulitchkova; Günter A. Schaub; Ute Lange; Roland Kaufmann; Götz Nowak
Protein Journal | 2012
Anna Jonebring; Ute Lange; Elke Bucha; Johanna Deinum; Margareta Elg; Ann Lövgren
Archive | 2006
Goetz Nowak; Elke Bucha; Ute Lange; Sven Zeeb; Alrun Schumann
Seminars in Thrombosis and Hemostasis | 2008
Götz Nowak; Ute Lange; Elke Bucha
Archive | 2001
Katrin Mende; Ute Lange; Goetz Nowak
Seminars in Thrombosis and Hemostasis | 2007
Götz Nowak; Ute Lange; Annett Wiesenburg; Elke Bucha
Thrombosis Research | 2012
Hans-Jürgen Kolde; Ute Lange; Elke Bucha
Archive | 2006
Goetz Nowak; Elke Bucha; Ute Lange
