Uwe Blunck
Charité
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Featured researches published by Uwe Blunck.
The Open Dentistry Journal | 2013
Christine Dirxen; Uwe Blunck; Saskia Preissner
Background: The development of ceramics during the last years was overwhelming. However, the focus was laid on the hardness and the strength of the restorative materials, resulting in high antagonistic tooth wear. This is critical for patients with bruxism. Objectives: The purpose of this study was to evaluate the clinical performance of the new double hybrid material for non-invasive treatment approaches. Material and Methods: The new approach of the material tested, was to modify ceramics to create a biomimetic material that has similar physical properties like dentin and enamel and is still as strong as conventional ceramics. Results: The produced crowns had a thickness ranging from 0.5 to 1.5 mm. To evaluate the clinical performance and durability of the crowns, the patient was examined half a year later. The crowns were still intact and soft tissues appeared healthy and this was achieved without any loss of tooth structure. Conclusions: The material can be milled to thin layers, but is still strong enough to prevent cracks which are stopped by the interpenetrating polymer within the network. Depending on the clinical situation, minimally- up to non-invasive restorations can be milled. Clinical Relevance: Dentistry aims in preservation of tooth structure. Patients suffering from loss of tooth structure (dental erosion, Amelogenesis imperfecta) or even young patients could benefit from minimally-invasive crowns. Due to a Vickers hardness between dentin and enamel, antagonistic tooth wear is very low. This might be interesting for treating patients with bruxism.
Dental Materials | 2008
Ronny Watzke; Uwe Blunck; Roland Frankenberger; Michael Naumann
OBJECTIVE The aim of this study was to light microscopically evaluate the homogeneity of the cement interface of an adhesively luted glass fiber post (GFP) by using a new cement application aid compared to a conventional post cementation method. METHODS Twenty artificial root canals (n = 5) received GFP under the following experimental conditions: I = RelyX Unicem applied with a new application aid, II = RelyX Unicem, III = Panavia F 2.0 and IV = Variolink II (groups II-IV with conventional post cementation). From all specimens standardized photographs were taken perpendicularly to the post surface under a light-optical microscope from two opposite sides. The depicted cement interfaces were analysed using surface-analyzing software and related to the complete three-dimensional surface of the cement interface. Non-parametric tests were used to compare median values of the observed inhomogeneities (alpha = 5%). RESULTS The median values (%) of inhomogeneities within the cement interface for the cervical, middle, and apical level of analysis were: I = 2, 2, 7; II = 15, 19, 24; III = 8, 16, 39; IV = 11, 16, 29. For the complete post length, median values (%) of inhomogeneities were: I = 4; II = 19; III = 20; IV = 18. SIGNIFICANCE The conventional application technique for luting endodontic post results in a large number of voids and bubbles. The combination of a flexible root-canal-shaped application aid achieves a more homogenous cement interface for the self-adhesive luting material tested.
International Endodontic Journal | 2010
Kerstin Bitter; Hendrik Meyer-Lueckel; N. Fotiadis; Uwe Blunck; Konrad Neumann; A.M. Kielbassa; Sebastian Paris
AIM To investigate the effects of endodontic treatment, post placement and ceramic restoration type on the fracture resistance of premolars. METHODOLOGY One hundred and twenty teeth maxillary premolars were allocated to four groups (A-D; n = 30). In group A, mesio-occlusal-distal-inlays with a buccal and palatal wall of 2 mm (MOD), in group B partial onlays with palatal cusp coverage and in group C total onlays with buccal and palatal cusp coverage were prepared. Group D served as untreated controls. Groups A-C were divided into three subgroups (n = 10): (i) teeth received solely the described preparations, (ii) teeth were root filled, (iii) teeth were root filled and quartz fibre posts were placed. Teeth were restored using Computer-assisted design/computer-assisted machining-ceramic-restorations and subjected to thermo-mechanical-loading; subsequently, the buccal cusp was loaded until fracture. RESULTS Group D revealed significantly higher fracture resistance [mean (standard deviation)] [738 (272) N] compared to all other groups (P < 0.05; post hoc test Dunnett). For groups A-C, fracture resistance was significantly affected by the restoration type (P = 0.043) and endodontic treatment/post placement (P = 0.039; 2-way anova). Group A [380 (146) N] showed significantly lower fracture resistance compared to group B [470 (158) N] (P = 0.048; post hoc test Tukey). Compared to non-endodontically treated teeth [487 (120) N], root filled teeth revealed significantly lower fracture resistance [389 (171) N] (P = 0.031). CONCLUSION The restoration of cavities with a remaining wall thickness of 2 mm using ceramic MOD-inlays is inferior with respect to the fracture resistance compared to partial onlay restorations. Root filled teeth without post placement show lower fracture resistance compared to non-endodontically treated teeth.
Journal of Dental Research | 2016
Falk Schwendicke; Gerd Göstemeyer; Uwe Blunck; Sebastian Paris; L.Y. Hsu; Yu-Kang Tu
For restoring cavitated dental lesions, whether carious or not, a large number of material combinations are available. We aimed to systematically review and synthesize data of comparative dental restorative trials. A systematic review was performed. Randomized controlled trials published between 2005 and 2015 were included that compared the survival of ≥2 restorative and/or adhesive materials (i.e., no need for restorative reintervention). Pairwise and Bayesian network meta-analyses were performed, with separate evaluations for cervical cavitated lesions and load-bearing posterior cavitated lesions in permanent and primary teeth. A total of 11,070 restorations (5,330 cervical, 5,740 load bearing) had been placed in 3,633 patients in the included trials. Thirty-six trials investigated restoration of cervical lesions (all in permanent teeth) and 36 of load-bearing lesions (8 in primary and 28 in permanent teeth). Resin-modified glass ionomer cements had the highest chance of survival in cervical cavitated lesions; composites or compomers placed via 2-step self-etch and 3-step etch-and-rinse adhesives were ranked next. Restorations placed with 2-step etch-and-rinse or 1-step self-etch adhesives performed worst. For load-bearing restorations, conventional composites had the highest probability of survival, while siloranes were found least suitable. Ambiguity remains regarding which adhesive strategy to use in load-bearing cavitated lesions. Most studies showed high risk of bias, and several comparisons were prone for publication bias. If prioritized for survival, resin-modified glass ionomer cements might be recommended to restore cervical lesions. For load-bearing ones, conventional or bulk fill composites seem most suitable. The available evidence is quantitatively and qualitatively insufficient for further recommendations, especially with regard to adhesive strategies in posterior load-bearing situations. Moreover, different material classifications might yield different findings on the same materials. Future trials should aim for sufficient power, longer follow-up times, and high internal validity to prove or refute differences between certain material combinations. An agreed material classification for future syntheses is desirable.
European Journal of Oral Sciences | 2013
Kerstin Bitter; Konrad Neumann; Uwe Blunck; Guido Sterzenbach
Irrigation after post space preparation and its effects on the bond strength of different adhesive strategies are still an issue of interest. The aim of the present study was to investigate the effects of various irrigation protocols (IPs) on the push-out bond strengths of fiber posts. One-hundred and fifty extracted human anterior teeth were divided into three groups (n = 50 each) and endodontically treated. The post space was irrigated before post placement using the following five IPs in each group: IP1 (control): 5 ml of distilled water; IP2: 5.25% sodium hypochlorite (NaOCl) applied with passive ultrasonic irrigation (PUI); IP3: 1% NaOCl applied with PUI; IP4: 18% ethylenediaminetetracetic acid (EDTA) followed by 5.25% NaOCl; and IP5: 2% chlorhexidine (CHX). Fiber posts placement in each group was performed using three different adhesive strategies. A self-etch adhesive system revealed higher bond strength (16.2 ± 6.9 MPa) compared with an etch-and-rinse adhesive (8.5 ± 4.2 MPa) and a self-adhesive resin cement (9.2 ± 4.7 MPa). The use of 18% EDTA/5.25% NaOCl increased the bond strength of the self-adhesive resin cement. Conversely, this IP decreased the bond strength for the etch-and-rinse adhesive system, whilst 1% NaOCl enhanced the bond strength for the same system. Consequently, each adhesive strategy may need to be adapted to a specific IP.
PLOS ONE | 2014
Kerstin Bitter; Christin Gläser; Konrad Neumann; Uwe Blunck; Roland Frankenberger
Purpose Restoration of endodontically treated teeth using fiber posts in a one-stage procedure gains more popularity and aims to create a secondary monoblock. Data of detailed analyses of so called “post-and-core-systems” with respect to morphological characteristics of the resin-dentin interface in combination with bond strength measurements of fiber posts luted with these materials are scarce. The present study aimed to analyze four different post-and-core-systems with two different adhesive approaches (self-etch and etch-and-rinse). Materials and Methods Human anterior teeth (n = 80) were endodontically treated and post space preparations and post placement were performed using the following systems: Rebilda Post/Rebilda DC/Futurabond DC (Voco) (RB), Luxapost/Luxacore Z/Luxabond Prebond and Luxabond A+B (DMG) (LC), X Post/Core X Flow/XP Bond and Self Cure Activator (Dentsply DeTrey) (CX), FRC Postec/MultiCore Flow/AdheSE DC (Ivoclar Vivadent) (MC). Adhesive systems and core materials of 10 specimens per group were labeled using fluorescent dyes and resin-dentin interfaces were analyzed using Confocal Laser Scanning Microscopy (CLSM). Bond strengths were evaluated using a push-out test. Data were analyzed using repeated measurement ANOVA and following post-hoc test. Results CLSM analyses revealed significant differences between groups with respect to the factors hybrid layer thickness (p<0.0005) and number of resin tags (p = 0.02; ANOVA). Bond strength was significantly affected by core material (p = 0.001), location inside the root canal (p<0.0005) and incorporation of fluorescent dyes (p = 0.036; ANOVA). CX [7.7 (4.4) MPa] demonstrated significantly lower bond strength compared to LC [14.2 (8.7) MPa] and RB [13.3 (3.7) MPa] (p<0.05; Tukey HSD) but did not differ significantly from MC [11.5 (3.5) MPa]. Conclusion It can be concluded that bond strengths inside the root canal were not affected by the adhesive approach of the post-and-core-system. All systems demonstrated homogenous hybrid layer formation and penetration into the dentinal tubules in spite of the complicating conditions for adhesion inside the root canal.
Materials | 2016
Gerd Goestemeyer; Uwe Blunck; Sebastian Paris; Falk Schwendicke
Background: The evidence stemming from trials on restorative materials is shaped not only by trial findings, but also trial design and validity. We aimed to evaluate both aspects in randomized controlled dental restorative trials published from 2005–2015. Methods: Using systematic review methodology, we retrieved trials comparing restorative or adhesive dental materials. Two authors independently assessed design, risk of bias, registration status, and findings of trials. Descriptive and regression analyses were performed. Results: 114 studies on 15,321 restorations placed mainly in permanent teeth of 5232 patients were included. Per trial, the median number of patients was 37 (25th/75th percentiles: 30/51). Follow-up was 24 (20/48) months. Seventeen percent of trials reported on sample size calculations, 2% had been registered. Most trials (90%) used US Public Health Service (USPHS) criteria, and had a high risk of bias. More recent trials were more likely to have been registered, to have reported on sample size calculations, to be of low risk of bias, and to use other than USPHS-criteria. Twenty-three percent of trials yielded significant differences between groups. The likelihood of such differences was significantly increased in older studies, studies with potential reporting bias, published in journals with high impact factor (>2), longer follow-up periods, and not using USPHS-criteria. Conclusions: The majority of dental restorative trials published from 2005–2015 had limited validity. Risk of bias decreased in more recent trials. Future trials should aim for high validity, be registered, and use defined and appropriate sample sizes, follow-up periods, and outcome measures.
Dental Materials | 2015
Falk Schwendicke; Uwe Blunck; Sebastian Paris; Gerd Göstemeyer
OBJECTIVES The choice of trial comparators might impact on the validity of the available evidence. We aimed at evaluating dental restorative trial networks and the underlying comparisons made, hypothesizing that certain comparators are disproportionally preferred or avoided. METHODS A systematic review was performed via Medline, CENTRAL and EMBASE. Randomized controlled trials on dental restoration or adhesive materials published 2005-2015 were included. Social network analysis techniques were used to assess trial networks. RESULTS 114 studies on 15321 restorations placed in 5232 patients were included. 57 and 53 trials investigated restoration of cervical and load-bearing cavities, respectively. Four trials on non-cervical, non-load-bearing cavities did not form a network and were not evaluated. The most frequently assessed material combination was hybrid composites placed using 2-step etch-and-rinse adhesives. In cervical cavities, the majority of trials compared adhesives, not restorative materials. In load-bearing cavities, testing other restorative materials (ormocers, compomers) was common, too. In both networks, comparisons within material classes were frequent. There was significant homophily (p<0.001), i.e. certain material classes were preferred as comparators, while this preference seemed to change with time. Only very few comparisons yielded significant differences between materials. SIGNIFICANCE The disproportional use of certain material classes as comparator might be due to their perceived role as gold standard. Compared with other scientific disciplines, dental restorative trial networks seem less prone for bias by comparator choice. Factors underlying the network geometry should be assessed to understand drivers of the research agenda.
Journal of Dental Research | 2016
Falk Schwendicke; Yu-Kang Tu; Uwe Blunck; Sebastian Paris; Gerd Göstemeyer
Industry sponsorship was found to potentially introduce bias into clinical trials. We assessed the effects of industry sponsorship on the design, comparator choice, and findings of randomized controlled trials on dental restorative materials. A systematic review was performed via MEDLINE, CENTRAL, and EMBASE. Randomized trials on dental restorative and adhesive materials published 2005 to 2015 were included. The design of sponsored and nonsponsored trials was compared statistically (risk of bias, treatment indication, setting, transferability, sample size). Comparator choice and network geometry of sponsored and nonsponsored trials were assessed via network analysis. Material performance rankings in different trial types were estimated via Bayesian network meta-analysis. Overall, 114 studies were included (15,321 restorations in 5,232 patients). We found 21 and 41 (18% and 36%) trials being clearly or possibly industry sponsored, respectively. Trial design of sponsored and nonsponsored trials did not significantly differ for most assessed items. Sponsored trials evaluated restorations of load-bearing cavities significantly more often than nonsponsored trials, had longer follow-up periods, and showed significantly increased risk of detection bias. Regardless of sponsorship status, comparisons were mainly performed within material classes. The proportion of trials comparing against gold standard restorative or adhesive materials did not differ between trial types. If ranked for performance according to the need to re-treat (best: least re-treatments), most material combinations were ranked similarly in sponsored and nonsponsored trials. The effect of industry sponsorship on dental restorative trials seems limited.
Clinical Oral Investigations | 2016
Kerstin Bitter; Anne Schubert; Konrad Neumann; Uwe Blunck; Guido Sterzenbach; Stefan Rüttermann
ObjectivesThe aim of the present study was to test a self-adhesive resin cement used as core build-up material in comparison to two commercially available core build-up materials.Materials and methodsForty human anterior teeth were endodontically treated and fiber post insertion (RelyX Fiber posts) and core build-ups were performed using two core build-up materials applied with an etch-and-rinse adhesive approach (Luxacore Dual-LC and Clearfil Core-CC) and an experimental self-adhesive resin cement (SAR) in two application modes (SAR Handmix and SAR Automix). Samples were subjected to thermo-mechanical loading. Margin integrity was determined using scanning electron microscopy (SEM), and maximum load capability (Fmax) was evaluated. Physical properties of the tested materials were also examined.ResultsFmax was significantly affected by the core build-up material (p < 0.0005; one-way ANOVA). CC [481 (158) N] revealed significantly higher Fmax compared to LC [226 (80) N], SAR Hand [205 (115), and SAR Automix [197 (134) N] (p < 0.05; Tukey-B). The percentage of margin quality “continuous margin” in enamel after thermo-mechanical loading (TML) differed significantly among groups (p < 0.0005; Kruskal-Wallis); CC demonstrated a significantly higher percentage of margin quality “continuous margin” compared to the other groups. Physical properties were significantly affected by the different core materials (p < 0.0005; ANOVA); CC and LC demonstrated significantly higher flexural strength compared to both SAR groups as well as significantly higher water sorption of both SAR groups compared to CC and LC.ConclusionWithin the limitations of the present in vitro study, we conclude that the investigated experimental self-adhesive resin cement is not suitable as a core build-up material due to the lower maximum load capability, low margin quality, and the data of the mechanical properties.Clinical relevanceThe investigated experimental self-adhesive resin cement cannot be recommended as a core build-up material.