Uwe Drescher

Muscular Oxygen Uptake Kinetics in Aged Adults.

Pulmonary oxygen uptake (V˙O2) kinetics and heart rate kinetics are influenced by age and fitness. Muscular V˙O2 kinetics can be estimated from heart rate and pulmonary V˙O2. In this study the applicability of a test using pseudo-random binary sequences in combination with a model to estimate muscular V˙O2 kinetics was tested. Muscular V˙O2 kinetics were expected to be faster than pulmonary V˙O2 kinetics, slowed in aged subjects and correlated with maximum V˙O2 and heart rate kinetics. 27 elderly subjects (73±3 years; 81.1±8.2 kg; 175±4.7 cm) participated. Cardiorespiratory kinetics were assessed using the maximum of cross-correlation functions, higher maxima implying faster kinetics. Muscular V˙O2 kinetics were faster than pulmonary V˙O2 kinetics (0.31±0.1 vs. 0.29±0.1 s; p=0.004). Heart rate kinetics were not correlated with muscular or pulmonary V˙O2 kinetics or maximum V˙O2. Muscular V˙O2 kinetics correlated with maximum V˙O2 (r=0.35; p=0.033). This suggests, that muscular V˙O2 kinetics are faster than estimates from pulmonary V˙O2 and related to maximum V˙O2 in aged subjects. In the future this experimental approach may help to characterize alterations in muscular V˙O2 under various conditions independent of motivation and maximal effort.

Analysis of heart rate and oxygen uptake kinetics studied by two different pseudo-random binary sequence work rate amplitudes

PURPOSE The aim of the study was to compare the kinetics responses of heart rate (HR), pulmonary (V˙O2pulm) and predicted muscular (V˙O2musc) oxygen uptake between two different pseudo-random binary sequence (PRBS) work rate (WR) amplitudes both below anaerobic threshold. METHODS Eight healthy individuals performed two PRBS WR protocols implying changes between 30W and 80W and between 30W and 110W. HR and V˙O2pulm were measured beat-to-beat and breath-by-breath, respectively. V˙O2musc was estimated applying the approach of Hoffmann et al. (Eur J Appl Physiol 113: 1745-1754, 2013) considering a circulatory model for venous return and cross-correlation functions (CCF) for the kinetics analysis. RESULTS HR and V˙O2musc kinetics seem to be independent of WR intensity (p>0.05). V˙O2pulm kinetics show prominent differences in the lag of the CCF maximum (39±9s; 31±4s; p<0.05). CONCLUSIONS A mean difference of 14W between the PRBS WR amplitudes impacts venous return significantly, while HR and V˙O2musc kinetics remain unchanged.

Oxygen uptake kinetics following six weeks of interval and continuous endurance exercise training − An explorative pilot study

PURPOSE The aim of the study was to compare the responses of pulmonary (V˙O2pulm) and muscle (V˙O2musc) oxygen uptake kinetics before (PRE) and after (POST) six weeks of endurance exercise training. METHODS Nine untrained individuals performed pseudo-random binary sequences work rate changes between 30W and 80W at PRE and POST training intervention. Heart rate (HR) and V˙O2pulm were measured beat-to-beat and breath-by-breath, respectively. V˙O2musc was estimated applying the approach of Hoffmann et al. (Eur J Appl Physiol 113: 1745-1754, 2013). RESULTS Maximal oxygen uptake showed significant increases from PRE (3.2±0.3Lmin-1) to POST (3.7±0.2Lmin-1; p<0.05). For HR, V˙O2pulm and V˙O2musc kinetics no significant changes from PRE to POST training intervention were observed (p>0.05). CONCLUSIONS Discrepancies in the adaptations of the involved exercise induced physiological systems seem to be responsible for the observed significant alterations in maximal V˙O2 after six weeks of the training intervention in contrast to no changes in the kinetics responses.

Effect of acute ambient temperature exposure on cardio-pulmonary and respiratory kinetics in men

Abstract Aim: The goal of the study was to compare the kinetic responses of heart rate (HR) and pulmonary (V̇O2pulm) and muscular (V̇O2musc) oxygen uptake during dynamic leg exercise across different acute ambient temperature conditions in a climatic chamber. Methods: Thirteen physically healthy, active, male volunteers demonstrated pseudorandom binary sequence (PRBS) work rate (WR) changes between 30 and 80 W at 15 °C, 25 °C and 35 °C, respectively. HR was measured beat-to-beat using an echocardiogram and V̇O2pulm by breath-by-breath gas exchange; V̇O2musc estimations were assessed by applying a circulatory model and cross-correlation functions. Results: No significant differences were observed across the various temperature conditions in each case for HR, V̇O2pulm or V̇O2musc kinetics (p > 0.05). Baroreflex regulation based on HR kinetics does not seem to be influenced between ambient temperatures of 15 °C and 35 °C during dynamic exercise. Conclusions: The results imply that ambient temperatures of 15 °C, 25 °C and 35 °C have no effect on HR, V̇O2pulm or V̇O2musc kinetics during dynamic moderate exercise. The applied approach may be of interest for assessments of the cardio-pulmonary and respiratory health statuses of individuals working or performing sports in extreme temperature environments. Furthermore, differentiation between systemic (e.g. cardio-dynamic: HR) and specific (e.g. exercising tissues: V̇O2musc) determinants of the relevant physiological systems may improve the evaluation of an individual’s health status.

Heart Rate and Oxygen Uptake Kinetics in Type 2 Diabetes Patients – A Pilot Study on the Influence of Cardiovascular Medication on Regulatory Processes

The aim of this pilot study was to investigate whether there are differences in heart rate and oxygen uptake kinetics in type 2 diabetes patients, considering their cardiovascular medication. It was hypothesized that cardiovascular medication would affect heart rate and oxygen uptake kinetics and that this could be detected using a standardized exercise test. 18 subjects were tested for maximal oxygen uptake. Kinetics were measured in a single test session with standardized, randomized moderate-intensity work rate changes. Time series analysis was used to estimate kinetics. Greater maxima in cross-correlation functions indicate faster kinetics. 6 patients did not take any cardiovascular medication, 6 subjects took peripherally acting medication and 6 patients were treated with centrally acting medication. Maximum oxygen uptake was not significantly different between groups. Significant main effects were identified regarding differences in muscular oxygen uptake kinetics and heart rate kinetics. Muscular oxygen uptake kinetics were significantly faster than heart rate kinetics in the group with no cardiovascular medication (maximum in cross-correlation function of muscular oxygen uptake vs. heart rate; 0.32±0.08 vs. 0.25±0.06; p=0.001) and in the group taking peripherally acting medication (0.34±0.05 vs. 0.28±0.05; p=0.009) but not in the patients taking centrally acting medication (0.28±0.05 vs. 0.30±0.07; n.s.). It can be concluded that regulatory processes for the achievement of a similar maximal oxygen uptake are different between the groups. The used standardized test provided plausible results for heart rate and oxygen uptake kinetics in a single measurement session in this patient group.The aim of this pilot study was to investigate whether there are differences in heart rate and oxygen uptake kinetics in type 2 diabetes patients, considering their cardiovascular medication. It was hypothesized that cardiovascular medication would affect heart rate and oxygen uptake kinetics and that this could be detected using a standardized exercise test. 18 subjects were tested for maximal oxygen uptake. Kinetics were measured in a single test session with standardized, randomized moderate-intensity work rate changes. Time series analysis was used to estimate kinetics. Greater maxima in cross-correlation functions indicate faster kinetics. 6 patients did not take any cardiovascular medication, 6 subjects took peripherally acting medication and 6 patients were treated with centrally acting medication. Maximum oxygen uptake was not significantly different between groups. Significant main effects were identified regarding differences in muscular oxygen uptake kinetics and heart rate kinetics. Muscular oxygen uptake kinetics were significantly faster than heart rate kinetics in the group with no cardiovascular medication (maximum in cross-correlation function of muscular oxygen uptake vs. heart rate; 0.32±0.08 vs. 0.25±0.06; p=0.001) and in the group taking peripherally acting medication (0.34±0.05 vs. 0.28±0.05; p=0.009) but not in the patients taking centrally acting medication (0.28±0.05 vs. 0.30±0.07; n.s.). It can be concluded that regulatory processes for the achievement of a similar maximal oxygen uptake are different between the groups. The used standardized test provided plausible results for heart rate and oxygen uptake kinetics in a single measurement session in this patient group.

An experimental paradigm for the assessment of realistic human multitasking

Human multitasking has been evaluated with paradigms that administered two—rarely three—concurrent tasks. In everyday life, however, we usually face an ever-changing sequence of distinct concurrent tasks. Available studies therefore provided valuable insights into our ability for dual tasking, but they did not address the natural interplay of dual tasking and task switching. The present study was undertaken to explore the feasibility of two new paradigms which replicate that interplay in virtual reality. We used car driving simulator software to implement a virtual car-driving task as well as a virtual street-crossing task. Either task was administered alone, as well as concurrently with a battery of loading tasks that mimicked activities of everyday life. The loading tasks used different sensory modalities, different cognitive processes, and different output channels and were presented in an ever-changing sequence. Cronbach’s alpha scores of key registered variables were high, which indicates that our approach is reliable. Driving and street-crossing performance deteriorated under multitask conditions, which indicates that our approach is sensitive to multitasking. This is the first study to demonstrate the feasibility of an experimental paradigm for the assessment of natural multitasking, i.e., of combined dual tasking and task switching. This paradigm could be of interest for basic science as well as for prevention and rehabilitation settings.

Impact of venous return on pulmonary oxygen uptake kinetics during dynamic exercise - In silico time series analyses from muscles to lungs

The aim of the present study was to investigate whether a single-compartment (SCM) and a multi-compartment (MCM) venous return model will produce significantly different time-delaying and distortive effects on pulmonary oxygen uptake (V̇o2pulm) responses with equal cardiac outputs (Q̇) and muscle oxygen uptake (V̇o2musc) inputs. For each model, 64 data sets were simulated with alternating Q̇ and V̇o2musc kinetics-time constants (τ) ranging from 10 to 80 s-as responses to pseudorandom binary sequence work rate (WR) changes. Kinetic analyses were performed by using cross-correlation functions (CCFs) between WR with V̇o2pulm and V̇o2musc. Higher maxima of the CCF courses indicate faster system responses-equal to smaller τ values of the variables of interest (e.g., τV̇o2musc). The models demonstrated a highly significant relationship for the resulting V̇o2pulm responses ( r = 0.976, P < 0.001, n = 64). Both models showed significant differences between V̇o2pulm and V̇o2musc kinetics for τV̇o2musc ranging from 10 to 30 s ( P < 0.05 each). In addition, a significant difference in V̇o2pulm kinetics ( P < 0.05) between the models was observed for very fast V̇o2musc kinetics (τ = 10 s). The combinations of fast Q̇ dynamics and slow V̇o2musc kinetics yield distinct deviations in the resultant V̇o2pulm responses compared with V̇o2musc kinetics. Therefore, the venous return models should be used with care and caution if the aim is to infer V̇o2musc by means of V̇o2pulm kinetics. Finally, the resultant V̇o2pulm responses seem to be complex and most likely unpredictable if no cardiodynamic measurements are available in vivo. NEW & NOTEWORTHY A single-compartment and a multi-compartment venous return model were tested to see whether they result in different pulmonary oxygen uptake (V̇o2pulm) kinetics from equal cardiac output and muscle oxygen uptake (V̇o2musc) kinetics. To infer V̇o2musc kinetics by means of V̇o2pulm kinetics, both models should only be used for V̇o2musc time constants ranging from 40 to 80 s. The resultant V̇o2pulm responses seem to be complex and most likely unpredictable if no cardiodynamic measurements are available.

Multitasking During Simulated Car Driving: A Comparison of Young and Older Persons

Human multitasking is typically studied by repeatedly presenting two tasks, either sequentially (task switch paradigms) or overlapping in time (dual-task paradigms). This is different from everyday life, which typically presents an ever-changing sequence of many different tasks. Realistic multitasking therefore requires an ongoing orchestration of task switching and dual-tasking. Here we investigate whether the age-related decay of multitasking, which has been documented with pure task-switch and pure dual-task paradigms, can also be quantified with a more realistic car driving paradigm. 63 young (20–30 years of age) and 61 older (65–75 years of age) participants were tested in an immersive driving simulator. They followed a car that occasionally slowed down and concurrently executed a mixed sequence of loading tasks that differed with respect to their sensory input modality, cognitive requirements and motor output channel. In two control conditions, the car-following or the loading task were administered alone. Older participants drove more slowly, more laterally and more variably than young ones, and this age difference was accentuated in the multitask-condition, particularly if the loading task took participants’ gaze and attention away from the road. In the latter case, 78% of older drivers veered off the road and 15% drove across the median. The corresponding values for young drivers were 40% and 0%, respectively. Our findings indicate that multitasking deteriorates in older age not only in typical laboratory paradigms, but also in paradigms that require orchestration of dual-tasking and task switching. They also indicate that older drivers are at a higher risk of causing an accident when they engage in a task that takes gaze and attention away from the road.

Gas exchange kinetics following concentric-eccentric isokinetic arm and leg exercise

PURPOSE To evaluate the effects of exercise velocity (60, 150, 240deg∙s-1) and muscle mass (arm vs leg) on changes in gas exchange and arterio-venous oxygen content difference (avDO2) following high-intensity concentric-eccentric isokinetic exercise. METHODS Fourteen subjects (26.9±3.1years) performed a 3×20-repetition isokinetic exercise protocol. Recovery beat-to-beat cardiac output (CO) and breath-by-breath gas exchange were recorded to determine post-exercise half-time (t1/2) for oxygen uptake (V˙O2pulm), carbon dioxide output (V˙CO2pulm), and ventilation (V˙E). RESULTS Significant differences of the t1/2 values were identified between 60 and 150deg∙s-1. Significant differences in the t1/2 values were observed between V˙O2pulm and V˙CO2pulm and between V˙CO2pulm and V˙E. The time to attain the first avDO2-peak showed significant differences between arm and leg exercise. CONCLUSIONS The present study illustrates, that V˙O2pulm kinetics are distorted due to non-linear CO dynamics. Therefore, it has to be taken into account, that V˙O2pulm may not be a valuable surrogate for muscular oxygen uptake kinetics in the recovery phases.

Influence of Weightlessness on Aerobic Capacity, Cardiac Output and Oxygen Uptake Kinetics

The exposure to weightlessness can have an impact on aerobic capacity as a result of changes in the cardiorespiratory and musculoskeletal systems. As a consequence, astronauts’ work capacities might be changed which would affect activities during the Space missions and after return to Earth or other environments with gravity, i.e. Mars or Moon. This chapter will give an overview about results from studies using cardiopulmonary exercise testing (CPET). This method allows to monitor astronauts’ fitness non-invasively and is, therefore, qualified for inflight measurements. Results from early Space flight until now will be compared with results from bedrest studies. Predominantly, the focus lies on peak oxygen uptake, heart rate and oxygen uptake kinetics. Since the specific methods and problems of CPET are related to the concepts of respiratory gas measurement, aspects of hardware, exercise protocols and data analysis will be discussed.