Is this you? Create Your Porfile
Avatar

Uwe Heinelt

Aventis Pharma

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Uwe Heinelt is active.

Explore More

Publication

Featured researches published by Uwe Heinelt.

Bioorganic & Medicinal Chemistry Letters | 2001

Solid-phase optimisation of achiral amidinobenzyl indoles as potent and selective factor Xa inhibitors

Uwe Heinelt; Silke Herok; Hans Matter; Peter Wildgoose

Starting from the achiral and potent factor Xa inhibitor 1, a new and flexible solid-phase optimisation strategy is described to reduce its cationic character. By replacing one positively charged side chain by a lipophilic substituent, a novel series of highly potent and selective achiral factor Xa inhibitors was discovered. The identified lipophilic replacements in the S4 pocket might be valuable for other approaches towards fXa inhibitors.

Journal of Medicinal Chemistry | 2002

Design and Quantitative Structure-Activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa

Hans Matter; Elisabeth Defossa; Uwe Heinelt; Peter-Michael Blohm; Detlev Schneider; Andrea Müller; Silke Herok; Herman Schreuder; Alexander Liesum; Volker Brachvogel; Petra Lönze; Armin Walser; Fahad Al-Obeidi; Peter Wildgoose

Archive | 1998

Indole derivatives as inhibitors or factor Xa

Elisabeth Defossa; Uwe Heinelt; Otmar Klingler; Gerhard Zoller; Fahad Al-Obeidi; Armin Walser; Peter Wildgoose; Hans Matter

Archive | 2001

SUBSTITUTED CINNAMIC ACID GUANIDIDES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT, AND MEDICAMENT COMPRISING THEM

Armin Hofmeister; Max Hropot; Uwe Heinelt; Markus Bleich; Hans-Jochen Lang

Archive | 1997

Xanthine compounds having terminally animated alkynol side chains

Ulrich Gebert; Elisabeth Defossa; Uwe Heinelt; Karl Rudolphi; John J. Grome

Archive | 2003

Substituted benzimidazoles, processes for their preparation, their use as medicaments, and medicaments comprising them

Armin Hofmeister; Uwe Heinelt; Hans-Jochen Lang; Markus Bleich; Klaus Wirth; Michael Gekle

Archive | 1999

Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity)

Elisabeth Defossa; Uwe Heinelt; Otmar Klingler; Gerhard Zoller; Hans Matter; Fahad Al-Obeidi; Armin Walser; Peter Wildgoose

Archive | 2004

Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines

Armin Hofmeister; Uwe Heinelt; Hans-Jochen Lang; Wendelin Frick; Markus Bleich; Klaus Wirth

Archive | 2016

Fused Tricyclic Benzimidazoles Derivatives As Modulators of TNF Activity

Rikki Peter Alexander; Calmiano, Mark, Daniel; Sabine Defays; Véronique Durieu; Michael Deligny; Jag Paul Heer; Victoria Elizabeth Jackson; Jean Keyaerts; Boris Kroeplien; Malcolm Mac Coss; Yogesh Anil Sabnis; Matthew Duncan Selby; Dominique Louis Léon Swinnen; Nathalie Van houtvin; Zhaoning Zhu; Volkmar Wehner; Uwe Heinelt

Archive | 1999

Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them

Elisabeth Defossa; Uwe Heinelt; Otmar Klingler; Gerhard Zoller; Hans Matter; Fahad Al-Obeidi; Armin Walser; Peter Wildgoose

Explore More

Collaboration

Dive into the Uwe Heinelt's collaboration.

Top Co-Authors
Avatar

Elisabeth Defossa

Aventis Pharma

View shared research outputs
Top Co-Authors
Avatar

Hans-Jochen Lang

Aventis Pharma

View shared research outputs
Top Co-Authors
Avatar

John J. Grome

University of Glasgow

View shared research outputs
Top Co-Authors
Avatar

Gerhard Zoller

Aventis Pharma

View shared research outputs
Top Co-Authors
Avatar

Otmar Klingler

Aventis Pharma

View shared research outputs
Top Co-Authors
Avatar

Peter Wildgoose

Aventis Pharma

View shared research outputs
Top Co-Authors
Avatar

Armin Hofmeister

Aventis Pharma

View shared research outputs
Top Co-Authors
Avatar

Karl Dr. Rudolphi

Aventis Pharma

View shared research outputs
Top Co-Authors
Avatar

Klaus Wirth

Aventis Pharma

View shared research outputs
Top Co-Authors
Avatar

Markus Bleich

University of Kiel

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge