Uzma Shaheen

Green Synthesis of Some New (Substituted Fluorobenzoylimino)-3-aryl-4-methyl-1,3-thiazolines

A series of 2-, 3-, and 4-substituted (fluorobenzoylimino)-3-aryl-4-methyl-1,3-thiazolines (2a–j) were synthesized in good yields by the base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas (1a–j) with α-bromoacetone in water. Compared to the reactions in conventional nonaqueous solvents under inert anhydrous conditions, the aqueous medium provides a much cleaner, more efficient, and simpler method for synthesis.

N-(4-Chloro­phen­yl)-3,4,5-trimethoxy­benzamide

In the title compound, C16H16ClNO4, the dihedral angle between the two aromatic rings is 67.33 (8)°. The crystal packing shows strong intermolecular N—H⋯O hydrogen bonds that link the molecules to form chains along [01].

1-(2-Fluoro-phen-yl)-3-(3,4,5-trimethoxy-benzo-yl)thio-urea.

The two m-methoxy groups of the title compound, C17H17FN2O4S, are almost coplanar with the aromatic ring [CH3—O—C—C = 5.8 (1) and 5.9 (1)°], whereas the methoxy group in the para position is bent out of the ring plane [78.6 (1)°]. Molecules are connected by intermolecular N—H⋯S hydrogen bonds to form centrosymmetric dimers that are stacked along the a axis.

1-(4-Fluoro­phen­yl)thio­urea

In the title compound, C7H7FN2S, the aromatic ring plane and the thiourea unit are twisted with a torsion angle C—C—N—C7 of 44.6 (2)°. In the crystal, N—H⋯S and N—H⋯F intermolecular hydrogen bonds link the molecules into infinite sheets that are stacked along the c axis.

4-Fluoro-N-[3-(2-fluoro-phen-yl)-4-methyl-2,3-dihydro-2-thienyl-idene]benzamide.

In the title compound, C17H12F2N2OS, the planar thiazole ring (r.m.s. deviation = 0.012 Å) makes dihedral angles of 15.08 (9) and 81.81 (6)° with the 4-fluorophenyl and 2-fluorophenyl rings, respectively. The 2-fluorophenyl ring is disordered over two orientations with site-occupancy factors of 0.810 (3) and 0.190 (3). The structure contains intermolecular C—H⋯O hydrogen bonds.