V. Dhayalan

(2-Methyl-1-phenyl-sulfonyl-1H-indol-3-yl)methanol.

In the title compound, C16H15NO3S, the plane of the phenyl ring forms a dihedral angle of 80.37 (8)° with the indole ring system. The crystal packing is stabilized by weak O—H⋯O hydrogen bonds which link the molecules into infinite chains along the a axis of the crystal.

Synthesis of 2-substituted 17β-hydroxy/17-methylene estratrienes and their in vitro cytotoxicity in human cancer cell cultures

Synthesis of various types of 2-(alkylaminomethyl) and 2-(aroyl) 17β-estradiol analogs are reported. The synthesis of similar types of 2-substituted 17-methylene estratriene analogs was also achieved. Synthesis of chalcone derivatives of 17β-estradiol and 17-methylene estratriene were also realized. All these 2-substituted estratrienes were tested for their antiproliferative activity by using four different cell lines from colon, lung, glioma and breast cancers. Among the various 2-substituted estratrienes, the compounds 10d, 14a-h and 17e were found to have in vitro antiproliferative activity comparable to that of parent analogs 1-4. Comparison of the SAR pattern of these 2-susbtituted estratriene derivatives confirmed that relatively, 17-methylene estratrienes are more active than that of 17β-estradiol analogs.

8,9-Dimethoxy-5-phenylsulfonyl-5H-benzo(b)carbazole

In the title compound, C24H19NO2S, the mean plane of the benzo[b]carbazole ring system makes a dihedral angle of 79.26 (5)° with the phenyl ring. The S atom is in a distorted tetrahedral configuration. The crystal structure exhibits weak C—H⋯O and C—H⋯π interactions.

One-Pot Synthesis of 1-Phenylsulfonyl-2-aroylindoles

Abstract Interaction of phenylsulfonyl-2-aminobenzaldehyde with 2-bromo-1-phenylethanones in the presence of K2CO3 followed by acid-catalyzed dehydration led to the formation of 1-phenylsulfonyl-2-aroylindoles. GRAPHICAL ABSTRACT

6-Meth­oxy-9-phenyl­sulfonyl-2-(2-thien­yl)-9H-thieno[2,3-b]carbazole

In the title compound, C25H17NO3S3, the mean planes of the thieno[2,3-b]carbazole and phenyl rings are inclined at an angle of 63.6 (1)°. The molecular structure features short intramolecular C—H⋯O contacts and the crystal packing exhibits weak intermolecular C—H⋯S and π–π interactions [centroid-to-centroid distances 3.734 (2)–3.888 (2) Å].

(4-Bromo­phen­yl)(1-phenyl­sulfonyl-1H-indol-2-yl)methanone

In the title compound, C21H14BrNO3S, the indole ring system forms dihedral angles of 65.64 (8) and 59.30 (8)°, respectively, with the phenyl and bromophenyl rings. In the crystal, molecules are connected by a C—H⋯O hydrogen bond, forming a chain along [101]. The chains are further connected by weak intermolecular C—H⋯π interactions, forming a layer parallel to the ac plane.

3-Bromo-meth-yl-2-chloro-meth-yl-1-phenyl-sulfon-yl-1H-indole.

In the title compound, C16H13BrClNO2S, the indole mean plane forms a dihedral angle of 73.59 (19)° with the phenyl ring. The molecular structure is stabilized by weak intramolecular C—H⋯O interactions. The Br atom is disordered over two positions with site occupancy factors of 0.7 and 0.3.

Lewis Acid–Mediated Domino Reaction of 3-Bromomethylthiophenes with Arenes/Heteroarenes

Abstract Lewis acid–mediated domino reaction of 3-bromomethylthiophenes with various types of arenes and heteroarenes is reported. GRAPHICAL ABSTRACT

7-Phenyl-sulfonyl-7H-benzofurano[2,3-b]carbazole.

In the title compound, C24H15NO3S, the dihedral angle between the phenyl ring and the carbozole system is 74.91 (6)°. The S atom exhibits a distorted tetrahedral geometry [N—S—C = 104.85 (8)°; O—S—O = 119.59 (9)°]. The crystal structure is established by weak intermolecular π–π interactions [centroid–centroid distances = 3.583 (2)–3.782 (2) Å].

7-Phenyl­sulfonyl-2,3-dihydro-7H-1,4-benzodioxino[6,7-b]carbazole

In the title compound, C24H17NO4S, the phenyl ring makes a dihedral angle of 88.12 (5)° with the carbazole unit. The molecular structure is stabilized by weak intramolecular C—H⋯O interactions and the crystal packing exhibits weak intermolecular C—H⋯O and C—H⋯π interactions. Two C atoms of the 2,3-dihydro-1,4-dioxine fragment are disordered over two positions with site-occupancy factors of 0.718 (11) and 0.282 (11).