V. Groysberg
University of California, Los Angeles
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Publication
Featured researches published by V. Groysberg.
Human Immunology | 2018
Joanna Schaenman; Maura Rossetti; Yael Korin; Tiffany Sidwell; V. Groysberg; Emily Liang; Sitaram Vangala; Nicholas Wisniewski; E. Chang; M. Bakir; Galyna Bondar; Martin Cadeiras; M. Kwon; Elaine F. Reed; Mario C. Deng
Immunologic impairment may contribute to poor outcomes after implantation of mechanical circulatory support device (MCSD), with infection often as a terminal event. The study of immune dysfunction is of special relevance given the growing numbers of older patients with heart disease. The aim of the study was to define which immunologic characteristics are associated with development of adverse clinical outcomes after MCSD implantation. We isolated peripheral blood mononuclear cells (PBMC) from patients pre- and up to 20 days post-MCSD implantation and analyzed them by multiparameter flow cytometry for T cell dysfunction, including terminal differentiation, exhaustion, and senescence. We used MELD-XI and SOFA scores measured at each time point as surrogate markers of clinical outcome. Older patients demonstrated increased frequencies of terminally differentiated T cells as well as NKT cells. Increased frequency of terminally differentiated and immune senescent T cells were associated with worse clinical outcome as measured by MELD-XI and SOFA scores, and with progression to infection and death. In conclusion, our data suggest that T cell dysfunction, independently from age, is associated with poor outcomes after MCSD implantation, providing a potential immunologic mechanism behind patient vulnerability to multiorgan dysfunction and death. This noninvasive approach to PBMC evaluation holds promise for candidate evaluation and patient monitoring.
Human Immunology | 2018
Joanna Schaenman; Maura Rossetti; Tiffany Sidwell; V. Groysberg; Gemalene Sunga; Yael Korin; Emily Liang; X. Zhou; Basmah Abdalla; Erik L. Lum; Suphamai Bunnapradist; T. Pham; Gabriel M. Danovitch; Elaine F. Reed
Older kidney transplant recipients experience increased rates of infection and death, and less rejection, compared with younger patients. However, little is known about immune dysfunction in older compared with younger kidney transplant recipients and whether it is associated with infection. We evaluated T cell phenotypes including maturation, immune senescence, and exhaustion in a novel investigation into differences in older compared with younger patients receiving identical immune suppression regimens. We evaluated PBMC from 60 kidney transplant recipients (23 older and 37 matched younger patients) by multiparameter immune phenotyping. Older kidney transplant recipients demonstrated decreased frequency of naïve CD4+ and CD8+ T cells, and increased frequency of terminally differentiated, immune senescent, and NK T cells expressing KLRG1. There was a trend towards increased frequency of T cell immune senescence in patients experiencing infection in the first year after transplantation, which reached statistical significance in a multivariate analysis. This pilot study reveals immune dysfunction in older compared with younger transplant recipients, and suggests a likely mechanism for increased vulnerability to infection. The ability to assess T cell maturation and immune senescence in transplant recipients offers the potential for risk stratification and customization of immune suppression to prevent infection and rejection after transplantation.
Transplantation direct | 2018
Emily Liang; Maura Rossetti; Tiffany Sidwell; V. Groysberg; Gema Sunga; Yael Korin; Sitaram Vangala; Basmah Abdalla; Erik L. Lum; Suphamai Bunnapradist; Phuong-Thu T. Pham; Gabriel M. Danovitch; Elaine F. Reed; Joanna Schaenman
Journal of Heart and Lung Transplantation | 2018
Joanna Schaenman; Maura Rossetti; Tiffany Sidwell; V. Groysberg; G. Sunga; E. Liang; S. Vangala; E. Chang; M. Bakir; Galyna Bondar; Martin Cadeiras; M. Kwon; Elaine F. Reed; Mario C. Deng
Journal of Heart and Lung Transplantation | 2018
T. Bao; R. Togashi; Martin Cadeiras; Joanna Schaenman; L. Masukawa; J. Hai; D. Chu; E. Chang; S. Kupiec-Weglinski; V. Groysberg; A. Le; R. Dod; C. Kahn; E. Oh; J. Do; C. Lumintang; T. Grogan; J. Meltzer; M. Kwon; Maura Rossetti; David Elashoff; Elaine F. Reed; P. Ping; Galyna Bondar; Mario C. Deng
Journal of Heart and Lung Transplantation | 2018
R. Togashi; L. Masukawa; T. Bao; Martin Cadeiras; Joanna Schaenman; J. Hai; D. Chu; E. Chang; A. Esmaeili; S. Kupiec-Weglinski; V. Groysberg; A. Le; R. Dod; C. Kahn; E. Oh; J. Do; C. Lumintang; T. Grogan; J. Meltzer; M. Kwon; Maura Rossetti; David Elashoff; Elaine F. Reed; P. Ping; Galyna Bondar; Mario C. Deng
Journal of Heart and Lung Transplantation | 2018
Galyna Bondar; T. Bao; R. Manoharan; R. Togashi; N. Agrawal; S. Ramachandrula; J. Hai; D. Chu; L. Masukawa; Martin Cadeiras; Joanna Schaenman; E. Chang; A. Le; R. Dod; C. Kahn; E. Oh; J. Do; C. Lumintang; S. Kupiec-Weglinski; V. Groysberg; T. Grogan; Maura Rossetti; David Elashoff; Elaine F. Reed; P. Ping; Mario C. Deng
Journal of Heart and Lung Transplantation | 2018
L. Masukawa; T. Bao; R. Dod; R. Togashi; Martin Cadeiras; Joanna Schaenman; J. Hai; D. Chu; E. Chang; S. Kupiec-Weglinski; V. Groysberg; A. Le; C. Kahn; E. Oh; J. Do; C. Lumintang; T. Grogan; J. Meltzer; M. Kwon; Maura Rossetti; David Elashoff; Elaine F. Reed; P. Ping; Galyna Bondar; Mario C. Deng
Open Forum Infectious Diseases | 2017
Emily Liang; Omer Beaird; Maura Rossetti; Tiffany Sidwell; V. Groysberg; Arun Karlamangla; Steve Cole; Elaine F. Reed; Joanna Schaenman
Open Forum Infectious Diseases | 2016
Joanna Schaenman; Emily Liang; Yael Korin; Tiffany Sidwell; V. Groysberg; Maura Rossetti; Arun Karlamangla; Elaine F. Reed