V. I. Itin

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

The tumour microenvironment regulates tumour progression and the spread of cancer in the body. Targeting the stromal cells that surround cancer cells could, therefore, improve the effectiveness of existing cancer treatments. Here, we show that magnetic nanoparticle clusters encapsulated inside a liposome can, under the influence of an external magnet, target both the tumour and its microenvironment. We use the outstanding T2 contrast properties (r2=573-1,286 s(-1) mM(-1)) of these ferri-liposomes, which are ∼95 nm in diameter, to non-invasively monitor drug delivery in vivo. We also visualize the targeting of the tumour microenvironment by the drug-loaded ferri-liposomes and the uptake of a model probe by cells. Furthermore, we used the ferri-liposomes to deliver a cathepsin protease inhibitor to a mammary tumour and its microenvironment in a mouse, which substantially reduced the size of the tumour compared with systemic delivery of the same drug.

Radiation-thermal synthesis of W-type hexaferrites

The results of investigations of the phase composition, structural parameters, static and dynamic magnetic properties of BaCo0.7Zn1.3Fe16O27 hexaferrites obtained by the method of self-propagation high-temperature synthesis in combination with mechanochemical activation and radiation-thermal post-sintering are presented. The prospects of the proposed energy-saving approach for the production of ferrite ceramics with a hexagonal structure is shown.

Structural and magnetic properties of SHS-produced multiphase W-Type hexaferrites: Influence of radiation-thermal treatment

Characterized were phase composition, structural parameters, magnetic parameters, and microwave absorption properties of BaCo0.7Zn1.3Fe16O27 hexaferrites produced by a method combining SHS, mechanical activation, and radiation-thermal treatment. The suggested process takes advantage of its lower time and energy consumption.

Influence of ageing on the phase composition, structure, and magnetic properties of nanopowders of oxide ferrimagnets

This paper reports on the observation of the aging of cubic oxide ferrimagnet nanopowders prepared by mechanochemical synthesis, which manifests itself in a variation of the phase composition, structural parameters, and main magnetic properties.

Effect of conditions of the mechanochemical synthesis and heat treatment on the phase composition, structural parameters, and magnetic properties of nanodimensional powders of cobalt spinel ferrite

Nanodimensional powders of cobalt spinel ferrite are obtained from salt systems by mechanochemical synthesis. The effect of the duration (τ) of mechanochemical synthesis and the temperature (t) of subsequent thermal treatment on the phase composition, structural parameters, and main magnetic properties of cobalt spinel ferrite is investigated by means of X-ray structural analysis, transmission electron microscopy, and X-ray fluorescent analysis. It is established that its yield and the average size of nanoparticles grow while the specific surface area and internal elastic stresses diminish as τ and t increase. The magnetization saturation in this case increases while variations in the effective magnetic-anisotropy field are of a more complex character, being conditioned mainly by the reduced contribution from the magnetoelastic component to the total energy of magnetic.

Mechanisms of the self-propagating high-temperature synthesis, phase composition, and magnetic properties of complex oxide ferrimagnets with M structure

Mechanisms of the combustion of reagent mixtures that form complex oxide ferrimagnets (hexaferrites with M structure) are investigated. The phase composition of the end product is found, depending on technological conditions that include self-propagating high-temperature synthesis with preliminary mechanical activation and/or subsequent ferritization. The basic static and dynamic magnetic properties of an end product synthesized in the optimum mode are determined. An energy-saving technique for manufacturing hexaferrites with M structure, making it possible to lower production costs substantially, is proposed.

Reaction of Stomatological Porcelain with Titanium and Titanium Nickelide during Sintering

The reaction of stomatological porcelain with titanium and titanium nickelide during sintering in the range 1050-1300°C was investigated. It was shown that when the sintering temperature is increased, silicides and other oxides are formed in place of the basic components (titanium and silicon oxides or titanium nickelide). Reactions in the porcelain ― titanium system take place in the solid state, but in the porcelain ― titanium nickelide system at temperatures above 1120°C they occur with the participation of liquid phases.

Mechanochemical synthesis, phase composition, structural parameters, and magnetic properties of manganese ferrospinels

Nanodimensional spherical powders of manganese and manganese-zinc ferrospinels have been obtained by mechanochemical synthesis. Their phase composition, structural parameters, morphology, dispersity, specific surface, and magnetic properties have been determined. It has been established that the addition of Zn2+ ions into a reaction mixture leads to an increase in the specific magnetization of manganese ferrite of up to 50%.

SHS-produced Co2+Ti4+-doped barium and strontium hexaferrites: Static and dynamic magnetic properties

Static and dynamic magnetic properties of SHS-produced BaFe12–2x(CoхTiх)O19 (х = 1.0, 1.1, 1.2) and SrFe12–2y(CoyTiy)O19 (0 ≤ y ≤ 1.0) hexaferrites were characterized by magnetization and FMR measurements. Dynamic properties of SrFe12–2y(CoyTiy)O19 hexaferrites were rationalized in terms of not only magnetic anisotropy but also the anisotropy of magnetomechanical ratio. SHS-produced ferrites can be recommended for designing radar-absorbent coatings and other SHF devices operating in the range 20–50 GHz.

Nanosized SnO2 and CoFe2O4 composite materials: Their preparation, properties and sorption activity

Nanosized SnO2 and CoFe2O4 oxide powders were obtained by mechanochemical synthesis from salt systems of appropriate reagents. Their physicochemical properties and absorption abilities were investigated with respect to microorganisms and organic impurities. The value of adhesion of Micrococcus albus and Pseudomonas putida bacterial cells amounted to 99.999–100% upon the filtration of microbial oil-contaminated suspension via columns filled with the nanosorbents under investigation. A well-developed specific surface area makes it possible to use nanosorbents to extensively rid drinking water of microorganisms and organic contaminants, which is of great importance for decreasing infectious human morbidity.