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Dive into the research topics where V. I. Staninets is active.

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Featured researches published by V. I. Staninets.


Russian Journal of Organic Chemistry | 2008

Electrophilic heterocyclization of 6-alken(yn)ylsulfanyl-pyrazolo[3,4-d]pyrimidin-4(5H)-ones

A. V. Bentya; R. I. Vas’kevich; A. V. Bol’but; M. V. Vovk; V. I. Staninets; A. V. Turov; Eduard B. Rusanov

Abstract6-Allylsulfanyl-1-arylpyrazolo[3,4-d]pyrimidin-4(5H)-ones react with iodine and sulfuric acid to give angular pyrazolothiazolopyrimidine derivatives. The reaction of 6-(prop-2-yn-1-ylsulfanyl)-1-(4-tolyl)-pyrazolo[3,4-d]pyrimidin-4(5H)-one with sulfuric acid gives angularly fused pyrazolo[4,3-e][1,3]thiazolo-[3,2-a]pyrimidin-4-one, whereas in the reaction with sodium methoxide linearly fused pyrazolo[3,4-d][1,3]-thiazolo[3,2-a]pyrimidin-4-one was formed. Linearly fused pyrazolo[3′,4′:4,5]pyrimido[2,1-b][1,3]thiazole derivatives were also obtained by reaction of 1-aryl-6-(3-phenylprop-2-en-1-ylsulfanyl)pyrazolo[3,4-d]pyrimidin-4(5H)-ones with sulfuric acid.


Russian Journal of Organic Chemistry | 2006

Synthesis of amino derivatives of triazolopyrimidine

R. I. Vas’kevich; P. V. Savitskii; Yu. L. Zborovskii; V. I. Staninets; Eduard B. Rusanov; Alexander N. Chernega

Heterocyclization of 1-(4,6-dimethylpyrimidin-2-yl)-4-R-thiosemicarbazides by the action of methyl iodide in ethanol in the presence of sodium acetate is accompanied by Dimroth rearrangement leading to the formation of 5,7-dimethyl-2-R-amino[1,2,4]triazolo[1,5-a]pyrimidines. Analogous heterocyclization of 4-aryl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thiosemicarbazides gives 3-arylamino-7-methyl-5-oxo-[1,2,4]triazolo[4,3-a]pyrimidines. The presence in the pyrimidine ring of a carbonyl group capable of forming hydrogen bond with protons of the amino group stabilizes the molecule, thus hampering the Dimroth rearrangement.


Russian Journal of Organic Chemistry | 2004

Reaction of 4-aryl-1-(4-oxo-3,4-dihydrothieno-[2,3+d]pyrimidin-2-yl)thiosemicarbazides with dimethyl acetylenedicarboxylate

R. I. Vas'kevich; Yu. L. Zborovskii; V. I. Staninets; Alexander N. Chernega

Abstract4-Aryl-1-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thiosemicarbazides react with dimethyl acetylenedicarboxylate in methanol to give the corresponding methyl {3-aryl-4-oxo-2-[(4-oxo-3,4-dihydro-thieno[2,3-d]pyrimidin-2-yl)hydrazono]-1,3-thiazolidin-5-ylidene}acetates, whereas in dioxane methyl 5-aryl-amino-2-methoxycarbonylmethyl-3-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)-2,3-dihydro-1,3,4-thiadiazole-2-carboxylates are mainly formed.


Chemistry of Heterocyclic Compounds | 2004

Halocyclization of substituted 2-(alkenylthio)pyrimidin-6-ones

N. Yu. Slivka; Yu. I. Gevaza; V. I. Staninets

Bromination and iodation of 2-(alkenylthio)pyrimidin-6-ones occur selectively and lead to formation of the corresponding 7-oxo-2,3-dihydrothiazolopyrimidinium or 8-oxo-3,4-dihydro-2H-pyrimidothiazinium salts. The selectivity of the reaction is controlled by the nature of the alkenyl substituent on the sulfur atom and the basicity of the N(1) and N(3) atoms of the pyrimidine ring. The iodation reaction rate increases as the basicity of the N(3) atom increases.


Chemistry of Heterocyclic Compounds | 2003

Heterocyclization reactions of 2-(2-propynylthio)-4(1H)-quinazolinone derivatives when treated with electrophilic and nucleophilic reagents

Yu. L. Zborovskii; V.V. Orysyk; A. A. Dobosh; V. I. Staninets; V. V. Pirozhenko; A. N. Chernega

Reaction of the potassium salt of 2-thioquinazolin-4-one with propargyl halides leads to formation of 2-propargylthioquinazolin-4-one derivatives, which undergo heterocyclization when they are treated with electrophilic or nucleophilic reagents and, depending on the nature of the cyclization agent, leads to formation of tricyclic systems with angular or linear structure.


Russian Journal of Organic Chemistry | 2012

Intramolecular electrophilic cyclization of functional derivatives of unsaturated compounds: III. Reaction of N,4-Diarylbut-3-enamides with arenesulfenyl chlorides. Synthesis of 5-aryl-4-arylsulfanyl-2,3,4,5-tetrahydro-1H-1-benzazepin-2-ones

A. I. Vas’kevich; N. M. Tsyzoryk; V. I. Staninets; Eduard B. Rusanov; M. V. Vovk

N-Aryl-4-phenylbut-3-enamides reacted with arenesulfenyl chlorides in chloroform to give N,4-diaryl-3-arylsulfanyl-4-chlorobutanamides, whereas in acetic acid in the presence of lithium perchlorate N-[4-arylsulfanyl-5-phenyltetrahydrofuran-2-ylidene]arenaminium perchlorates were obtained. Reactions of arenesulfenyl chlorides with N,4-diarylbut-3-enamides having strong electron-donating groups in positions 3 and 4 of the N-aryl substituent afforded 5-aryl-4-arylsulfanyl-2,3,4,5-tetrahydro-1H-1-benzazepin-2-ones.


Russian Journal of Organic Chemistry | 2007

Heterocyclization of N-Hetaryl-N′-(prop-2-en-1-yl)thioureas by the action of sulfuryl chloride

Yu. L. Zborovskii; V.V. Orysyk; V. I. Staninets; Eduard B. Rusanov; Alexander N. Chernega

Cyclization of N-hetaryl-N′-(prop-2-en-1-yl)thioureas by the action of sulfuryl chloride leads to the formation of the corresponding 2-hetarylimino-5-chloromethylthiazolidine hydrochlorides which are converted into the free bases by treatment with aqueous sodium sulfite.


Russian Journal of Organic Chemistry | 2006

Synthesis of fused triazolothienopyrimidine derivatives

R. I. Vas’kevich; P. V. Savitskii; Yu. L. Zborovskii; V. I. Staninets; A. V. Turov; Alexander N. Chernega

Reactions of substituted 1-(thieno[2,3-d]pyrimidin-2-yl)-4-arylthiosemicarbazides with methyl iodide led to the formation of fused triazolothienopyrimidine derivatives.


Russian Journal of Organic Chemistry | 2011

Synthesis of New Imidazo(1,2-a)pyrazolo(4,3-e)pyrimidin- 4(6H)-one Derivatives by Iodocyclization of 6-Alkenyl(alkynyl)- aminopyrazolo(3,4-d)pyrimidin-4(5H)-ones

A. V. Bentya; R. I. Vas’kevich; A. V. Turov; Eduard B. Rusanov; M. V. Vovk; V. I. Staninets

Abstract6-Allyl(diallyl, prop-2-yn-1-yl)amino-1-R-pyrazolo[3,4-d]pyrimidin-4(5H)-ones reacted with iodine to give angularly fused 8-iodomethyl-7,8-dihydro-1-R-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(6H)-ones which were treated with sodium acetate to obtain 8-methylidene-1-R-7,8-dihydroimidazo[1,2-a]pyrazolo-[4,3-e]pyrimidin-4(6H)-ones as a result of elimination of hydrogen iodide. 8-Methylidene-1-R-7,8-dihydroimidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(6H)-ones were converted into 8-methyl-1-R-imidazo[1,2-a]pyrazolo-[4,3-e]pyrimidin-4(5H)-ones on heating to the melting point. 8-Methylidene-1-phenyl-7,8-dihydroimidazo-[1,2-a]pyrazolo[4,3-e]pyrimidin-4(6H)-one underwent isomerization into linearly fused 6-methyl-1-phenyl-1,8-dihydro-4H-imidazo[1,2-a]pyrazolo[3,4-d]pyrimidin-4-one on heating in sulfuric acid.


Chemistry of Heterocyclic Compounds | 2003

Synthesis of Thiazino- and Thiazoloquinazolinones by Cyclization of S-(2-Propenyl) Derivatives of 2-Thioxo-2,3-dihydro-4(1H)-quinazolinone

V.V. Orysyk; Yu. L. Zborovskii; V. I. Staninets; A. A. Dobosh; S. M. Khripak

Interaction of potassium salts of quinazolin-2-thiol-4-one with γ-substituted allyl halides gave thiazoloquinazolinones with linear or angular structures depending on the structure of the carbonyl radical. S-Allyl substituted quinazolin-2-thiol-4-one reacted with halogens to give iminium salts of thiazinoquinazolinone with an angular structure. The conversion of these salts to the corresponding bases and thiazoloquinazolinones has been studied.

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R. I. Vas’kevich

National Academy of Sciences of Ukraine

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Yu. I. Gevaza

National Academy of Sciences of Ukraine

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Yu. L. Zborovskii

National Academy of Sciences of Ukraine

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Eduard B. Rusanov

National Academy of Sciences of Ukraine

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Alexander N. Chernega

National Academy of Sciences of Ukraine

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M. V. Vovk

National Academy of Sciences of Ukraine

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A. I. Vas’kevich

National Academy of Sciences of Ukraine

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A. V. Bentya

National Academy of Sciences of Ukraine

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P. V. Savitskii

National Academy of Sciences of Ukraine

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V.V. Orysyk

National Academy of Sciences of Ukraine

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