V. Kreil

A pharmacokinetic comparison of meloxicam and ketoprofen following oral administration to healthy dogs

AbstractKetoprofen (KTP) and meloxicam (MLX) are non-steroidal anti-inflamatory drugs used extensively in veterinary medicine. The pharmacokinetics of these drugs were studied in eight dogs following a single oral dose of 1 mg/kg of KTP as a racemate or 0.2 mg/kg of MLX. The concentrations of the drugs in plasma were determined by high-performance liquid chromatography (HPLC). There were differences between the disposition curves of the KTP enantiomers, confirming that the pharmacokinetics of KTP is enantioselective. (S)-(+)-KTP was the predominant enantiomer; the S:R ratio in the plasma increased from 2.58±0.38 at 15 min to 5.72±2.35 at 1 h. The area under the concentration–time curve (AUC) of (S)-(+)-KTP was approximately 6 times greater than that of (R)-(–)-KTP. The mean (±SD) pharmacokinetic parameters for (S)-(+)-KTP were characterized as Tmax = 0.76±0.19 h, Cmax = 2.02±0.41 μg/ml, t

Pharmacokinetics of erythromycin after the administration of intravenous and various oral dosage forms to dogs

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Comparative pharmacokinetics of intravenous cephalexin in pregnant, lactating, and nonpregnant, nonlactating goats

= 1.65±0.48 h, AUC = 6.06±1.16 μg.h/ml, Vd/F = 0.39±0.07 L/kg, Cl/F = 170±39 ml/(kg.h). The mean (±SD) pharmacokinetic parameters of MLX were Tmax = 8.5±1.91 h, Cmax = 0.82±0.29 μg/ml, t

Lack of interaction of metoclopramide on oral amoxicillin kinetics in dogs

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Multiple once-daily dose pharmacokinetics and renal safety of gentamicin in dogs

= 12.13±2.15 h, AUCinf = 15.41±1.24 μg.h/ml, Vd/F = 0.23±0.03 L/kg, and Cl/F = 10±1.4 ml/(kg.h). Our results indicate significant pharmacokinetic differences between MLX and KTP after therapeutic doses.

Pharmacokinetics of ceftriaxone administered by the intravenous, intramuscular or subcutaneous routes to dogs.

In order to perform pharmacokinetic studies involving multiple blood sampling, repeated at variable intervals of time, a simple and reliable non-surgical jugular catheterization technique was developed. Six cats were catheterized 48 times using an indwelling through-the-needle type catheter (22G and 20.3 cm) placed into the jugular vein through an over-the-needle type (20G and 32 mm). Catheters remained in place for 1–13 days (median 3 days) without loss of patency until removal. Each jugular was catheterized a range of 2–6 times, with a total indwelling time of 4–33 days. No clinical signs of phlebitis, thrombosis or sepsis were observed either during or after the studies. This technique allows an easy, non-painful, non-stressful blood withdrawal during extended sampling periods, with minimal damage of the veins.