V. Mangili

Cancer antigen 15/3: possible diagnostic use in veterinary clinical oncology. Preliminary study

The cancer antigen 15/3 is a mucin that is associated with the cell membrane, encoded by the MUC1 gene, and recognized by the monoclonal-clone DF3 antibody. The latter antigen was discovered to be specific for both the identification of human mammary neoplasia and during patient follow-up evaluations. The aim of this study is to report and compare the results of the application of direct chemiluminescence in canine blood sera and the kit utilized in human medicine for the determination of Ca 15/3 to verify the diagnostic efficiency of the kit in cases presenting mammary tumors. Specifically, CA 15/3 has proven to be measurable in all samples assayed to distinguish clinically healthy subjects from those with mammary neoplasia.

Acute Myeloid Leukaemia in Five Dogs: Clinical Findings and Cytochemical Characterization

M.T. Antognoni1*, V. Mangili1, A. Spaterna2 and G. Fruganti1 1Department of Clinical Sciences, Section of Internal Medicine, Faculty of Veterinary Medicine, University of Perugia, Perugia; 2Department of Veterinary Sciences, Clinical Section, Faculty of Veterinary Medicine, University of Camerino, Camerino, Italy *Correspondence: Dipartimento di Patologia, Diagnostica e Clinica Veterinaria, Sezione di Medicina Interna, Facolta di Medicina Veterinaria, Universita di Perugia, 06126 Perugia, Italy E-mail: mta@unipg.it

Assessment and Behavior of Alphafetoprotein (AFP), Antigen Cancer 15/3 (CA 15/3), Carcinembryonal Antigen (CEA) in Clinical Oncology of the Dog: Preliminary Study

Marchesi, M.C., Conti, M.B., Pieramati, C., Mangili, V. and Fruganti, G. 2007. Assessment and Behavior of Alphafetoprotein (AFP), Antigen Cancer 15/3 (CA 15/3), Carcinembryonal Antigen (CEA) in Clinical Oncology of the Dog: Preliminary Study. Veterinary Research Communications, 31(Suppl. 1), 301–304