V. Ninjoor
Bhabha Atomic Research Centre
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Featured researches published by V. Ninjoor.
Journal of Biosciences | 1989
P. Harikumar; T. Darshini; Aditi Dutt; V. Ninjoor
Highly pure lysosomes were isolated from buffalo(Bubalus bubalis) kidney cortex by a procedure involving differential and isopycnic Percoll density gradient centrifugations. Arylsulphatase, N-acetyl-Β-glucosamindase and cathepsin D in the lysosomal preparation were 26–45-fold enriched over the homogenate. The purified lysosomes contained less than 0·06% of mitochondrial, microsomal and peroxisomal marker enzymes. In the electron micrographs the particles appeared as large dense granules of size 0·3-1·9 µm with no apparent structural features belonging to mitochondria or microsomes. The isolation procedure was also found to be suitable to obtain highly pure lysosome particles from renal cortex of other sources such as rat, lamb and beef. No ultracentrifugation steps were involved in the procedure
Journal of Biosciences | 1986
P. Harikumar; V. Ninjoor
The response of rat liver lysosomes to starvation and administration of lysosomotropic agentsviz. Triton WR-1339 and [131I]-human serum albumin, was assessed in terms of their distribution pattern after isopycnic sucrose density gradient centrifugation. Starvation induced changes in lysosomes appeared to be similar to that produced by the detergent uptake. Both the treatments caused a distinct decline in the equilibration densities of the organelles. On the other hand, injected labelled protein failed to comigrate with the lysosomal markers in starved as well as Triton treated rats and conspicuously remained in a region of high specific gravity in the gradient. These findings indicate retarded fusion between secondary lysosomes and [131I]-human serum albumin containing phagosomes in the livers of rats subjected to starvation or detergent treatment
Journal of Biosciences | 1985
Brij Bhushan; V. Ninjoor; G. B. Nadkarni
Exposure of vitamin A acetate in freely dissolved state to γ-radiationin vitro caused a dose dependent degradation accompanied by the formation of new products. The radiation degradation products were separated by chromatography using step gradient elution. The parent molecule, vitamin A acetate, induced negligible haemolysis of erythrocytes. In contrast, the polar products formed by irradiation were found to be potent haemolysing agents. A highly polar product, eluted with methanol revealed maximum haemolytic activity. Acetylation of these products resulted in loss of their haemolytic properties. Similarly, vitamin E acetate, a known stabilizer of the biomembranes, after irradiation yielded products which caused haemolysis of erythrocytes. It was demonstrated that irradiation introduces hydroxyl groups which impart haemolytic properties to the radiation degradation products of vitamin A
Journal of Food Science | 1988
S.V. Sherekar; M. S. Gore; V. Ninjoor
Journal of Food Science | 1987
S.N. Doke; V. Ninjoor
Journal of Food Science | 1981
S. B. Warrier; V. Ninjoor
World review of nutrition and dietetics | 1978
V. Ninjoor; Brij Bhushan; G. B. Nadkarni
Journal of Food Science | 1974
P. Harikumar; V. Ninjoor; S. B. Warrier; Brij Bhushan; U. S. Kumta
Journal of Food Science | 1985
S. B. Warrier; V. Ninjoor; G. B. Nadkarni
Agricultural and biological chemistry | 1981
Brij Bhushan; P. Harikumar; V. Ninjoor