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Dive into the research topics where V. Prabhakar is active.

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Featured researches published by V. Prabhakar.


Asian Journal of Research in Chemistry | 2017

Application of Chalcones in Synthesis of Novel 1, 5-Benzodiazepine Derivatives Containing Thieno [2, 3-d] Pyrimidine Core Unit and its Biological Activity Screening

V. Prabhakar; Kondra Sudhakar Babu; L.K. Ravindranath; M. Sahanoor Basha; J. Latha

Di azepines, which were synthesized by different methods shown in literature and also Di azepines are great importance in heterocyclic chemistry and more importance in biology and pharmacology. Di azepines are very biological active molecules. In this work A new series of 1, 5-Benzodizepine derivatives were synthesized from chalcones and evaluated for their Antimicrobial activities. First Chalcones were prepared by treatment of Thieno [2, 3-d] pyrimidine-6-carbaldehyde with different acetophenones by Claisen-Schimidt Condensation. Various Benzodiazepines derivatives were prepared by reaction of Chalcone in DMF with o-phenylene di amine in presence of piperidine. The structures of the newly synthesized Benzodiazepine derivatives have been established on the basis of their spectral data. The synthesized selected compounds were evaluated for their antimicrobial activities.


Asian Journal of Research in Chemistry | 2017

Design, Synthesis, Structural Elucidation and Antimicrobial Screening of Novel 1, 5-Benzothiazepine Derivatives Derived from Thieno [3, 2-d] Pyrimidine Nucleus

V. Prabhakar; Kondra Sudhakar Babu; L.K. Ravindranath; J. Latha; B. Venkateswarlu

1, 5-Benzo Thiazepine is the Main Seven membered Heterocyclic ring systems reported for their cardiac and Psychotherapeutic activities.1,5 Benzo Thiazepines were highlighted as important Biologically active Scaffolds. In This Article New series of benzo [b] [1, 5]-thiazepine derivatives 6 a-j were synthesized by applying the cyclo condensation of (E)-3-(thieno [3, 2-d] pyrimidin-6-yl)-1-p-Substituted prop-2-en-1-one derivatives 4a-j with 2-amino thio phenol (5) in DMF. The new intermediate Chalcone derivatives 4a-j were obtained from interaction of various P-substituted Acetophenone&Heterocyclic Acetyl derivatives 3(a-j) and thieno[3,2-d]pyrimidine-7-carbaldehyde. The synthesized 1, 5-benzothiazepines 6a-j have been screened for their antimicrobial activity. From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 6h, 6e, 6i and 6d possess good activity.


Asian Journal of Research in Chemistry | 2016

Design, Synthesis and Activity of Novel Quinazoline Derivatives Linked with various Sulphonamides

V. Prabhakar; B. Venkateswarlu; Punagani Bhargavi; Sura Jagadeesh

Quinazoline nucleus is present in various compounds and it is responsible for diverse biological activities. The present work mainly focused on the Quinazolines with potential activities that are now in development. The objective of this research work is to synthesize various compounds containing Quinazoline moiety and their derivatives as well as characterising the compounds by spectral analysis and screening for antimicrobial and anticancer activities. The structures of synthesized compounds were confirmed by various spectroscopic methods such as IR, NMR and mass spectroscopy. The products were evaluated for their antimicrobial activity against several microbes. Some of the compounds exhibited potent anti-bacterial activity as well as anti-fungal activity. Among the Novel Quinazoline derivatives 8i, 8j, 8d shows Excellent Anti-microbial activity


Asian Journal of Research in Chemistry | 2016

Synthesis and Anti-microbial Activity of Novel Isoxazoline Mannich base Derivatives containing Carbazole Ring

V. Prabhakar; K. Sudhakar Babu; L.K. Ravindranath; P. V. Ramana Reddy; J. Latha

A Novel Series of Compounds were synthesized by Condensation reaction of Carbazole aldehyde with Substituted Acetophenone derivatives 4 (a-d) in presence of alcoholic Sodium hydroxide Solution to get Chalcone Intermediates 5 (a-d), which were further treated hydroxyl amine hydrochloride in presence of Pyridine to get Iso Oxazoline Derivatives 6 (a-d). The latter were refluxed with Substituted Primary amines and formaldehyde for 8–10 hrs to get Mannich bases. The Structures of new compounds were confirmed by IR and 1H NMR and 13C NMR Spectral Data. Anti-bacterial and Anti-fungal Activities were evaluated and compared with the standard drugs, some compounds of the series Exhibited Promising Anti-microbial and Anti-fungal Activity Compared to Standard Drugs.


Archive | 2015

SYNTHESIS, CHARACTERIZATION AND MASS ANALYSIS OF NOVEL TRI SUBSTITUTED QUINAZOLINE-UREA DERIVATIVES BEARING TRANS SUBSTITUTED MORPHOLINE AND AZETIDINONE MOIETIES.

K. Sudhakar Babu; L.K. Ravindranath; J. Latha; V. Prabhakar


Asian Journal of Research in Chemistry | 2017

Synthesis and Biological Activities of Novel Thieno [3, 2-d] Pyrimidine Derivatives

V. Prabhakar; K. Sudhakar Babu; L.K. Ravindranath; B. Venkateswarlu


International Journal of Chemical Studies | 2016

Synthesis and anti-bacterial, anti-fungal activity of novel pyrazoline derivatives containing phenothiazine ring

V. Prabhakar; K Sudhakar Babu; L.K. Ravindranath; P Guru Pratap Reddy; J. Latha


Archive | 2015

FACILE AND EFFICIENT ONE-POT SYNTHESIS OF BENZIMIDAZOLES USING LANTHANIDE TRIFLATE CATALYST

V. Prabhakar; K. Sudhakar Babu; J. Latha


Archive | 2015

COPPER (II) TRIFLATE AS AN EFFICIENT AND RE USABLE CATALYST FOR FACILE SYNTHESIS OF BENZOXAZOLES AND BENZOTHIAZOLES IN AQUEOUS MEDIUM

V. Prabhakar; K. Sudhakar Babu; J. Latha


Archive | 2015

Synthesis, Characterization and biological evaluation of novel Pyrimidine linked 1,3,4-oxadiazoles possessing Piperdine, Morpholine, Thiomorpholine, N-Methyl Piperazine with Tri fluoro methyl moieties

K. Sudhakar Babu; V. Prabhakar; L.K. Ravindranath; J. Latha

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J. Latha

University College of Engineering

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L.K. Ravindranath

Sri Krishnadevaraya University

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Kondra Sudhakar Babu

Sri Krishnadevaraya University

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