V. Ravikanth

Zeolite Catalyzed Synthesis of bis (Indolyl) Methanes

Abstract HY-Zeolite is found to be a versatile catalyst for the electrophilic substitution reaction of indoles with carbonyl compounds to afford the corresponding bis(indolyl) methanes in good yields. #IICT Communication No. 011208.

A new BIS-Andrographolide Ether from Andrographis paniculata Nees and evaluation of anti-HIV activity

Novel bis-andrographolide ether (1) and six known compounds andrographolide, 14-deoxy-11,12-didehydroandrographolide, andrograpanin, 14-deoxyandrographolide, (±)-5-hydroxy-7,8-dimethoxyflavanone, and 5-hydroxy-7,8-dimethoxyflavone have been isolated from the aerial parts of Andrographis paniculata and their structures were established by spectral data. All the isolates were tested for the anti-HIV and cytotoxic activity.

A new triterpenoid from the fern Adiantum lunulatum and evaluation of antibacterial activity

A new triterpenoid, 22,29xi-epoxy-30-norhopane-13beta-ol (1) was isolated together with six known compounds viz., fern-9(11)-en-6alpha-ol. fern-9(11)-ene, fern-9(11)-en-25-oic acid, fern-9(11)-en-28-ol, filicenol-B, adiantone and oxidation product of fern-9(11)-en-6alpha-ol obtained as 6-oxofern-9(11)-ene from the whole plant of Adiantum lunulatum, and their structures were elucidated by means of spectroscopic analysis and antibacterial evaluation of these compounds were conducted.

An immunosuppressive tryptophan-derived alkaloid from Lepidagathis cristata

An immunosuppressive, tryptophan-derived alkaloid cristatin A (1), and two known compounds, cycloartenol and stigmasta-5,11(12)-diene-3 beta-ol, were isolated from the whole plant Lepidagathis cristata Willd. The structures of the isolates were established by interpretation of their spectral data.

Inhibitory activity of homoisoflavonoids from Caesalpinia sappan against Beauveria bassiana.

Four homoisoflavonoids, 4-O-methylsappanol (1), protosappanin A (2), brazilin (3) and caeasalpin J (4), isolated from Caesalpinia sappan, were tested for inhibitory activity against Beauveria bassiana. Compound 1 showed activity against this fungus.

Macrocyclic diterpenes from Euphorbia nivulia

The latex of Euphorbia nivulia afforded two ingol diterpenes 3,12-diacetyl-8-benzoylingol (4) and 3,12-diacetyl-7-benzoyl-8-nicotinylingol (5) along with three known ingol diterpenes 1, 2,and 3, and two known triterpenes cycloart-25-en-3beta-ol and cyclonivulinol. Their structures have been assigned on the basis of their structural data as well as their acetylated products. The diterpenes 1-5 were tested for the LPS induced PGE(2) inhibition activity.

Amberlyst-15-Catalyzed Efficient Synthesis of 1,1-Diacetates from Aldehydes

Abstract Amberlyst-15 was found to be an efficient catalyst for acylation reaction of aldehydes with acetic anhydride at room temperature in dichloromethane. #IICT Communication No. 01/09/04.

An unusual novel triterpenoid ether, multiflor-7-en-12,13-ether and a new multiflor-7-en-12α-ol from Wattakakavolubilis

Abstract A new multiflor-7-en-12α-ol ( 1 ) and a novel multiflor-7-en-12,13-ether ( 2 ) triterpenoid were isolated from the leaves of Wattakaka volubilis and their structures were established by means of spectroscopic analysis.

A novel Ceramide from the Indian marine sponge Fasciospongia cavernosa

A new ceramide 1, has been isolated along with a known compound 3,6-diacetoxy-cholest-7-en-3β,5α,6β-triol (2) from a marine sponge Fasciospongia cavernosa collected off the Mandapam coast in the Gulf of Manner, India. The structures of 1 and 2 were determined by spectroscopic analysis.