V. V. Grigor’ev
Russian Academy of Sciences
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by V. V. Grigor’ev.
Russian Chemical Bulletin | 2014
V. B. Sokolov; A. Yu. Aksinenko; N. S. Nikolaeva; V. V. Grigor’ev; A. S. Kinzirsky; S. O. Bachurin
A method for the modification of tetrahydrocarbazoles with the 2-(5-fluoropyridin-3-yl)ethyl fragment was suggest, which consists in the reaction of 5-fluoro-3-vinylpyridine with tetrahydrocarbazoles under conditions of fluoride ion catalysis and leads to the earlier unknown 9-[2-(5-fluoropyridin-3-yl)ethyl]-2,3,4,9-tetrahydro-1H-carbazoles. Method of radioligand binding was used to study the influence of compounds synthesized on neuronal NMDA-receptors.
Russian Chemical Bulletin | 2016
V. B. Sokolov; A. Yu. Aksinenko; T. V. Goreva; T. A. Epishina; V. V. Grigor’ev; A. V. Gabrel´yan; D. V. Vinogradova; Margarita E. Neganova; E. F. Shevtsova; S. O. Bachurin
A synthetic approach to the design of new multitarget neuroprotectors consisting in combination of the tetrahydrocarbazole and aminoadamantane pharmacophore fragments through a 2-hydroxypropylene spacer upon the reaction of 9-oxiranylmethyl-2,3,4,9-tetrahydro-1H-carbazoles and aminoadamantanes, which affords 1-(adamantan-1-ylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ols, is proposed. The effect of the synthesized compounds on the neuronal NMDA receptors and the functional characteristics of rat liver mitochondria was studied.
Russian Chemical Bulletin | 2013
S. O. Bachurin; V. B. Sokolov; A. Yu. Aksinenko; T. A. Epishina; T. V. Goreva; V. V. Grigor’ev; V. L. Zamoiskii; A. V. Gabrel´yan
An approach to the modification of biologically active γ-carbolines by the 2-trifluoromethylimidazo[1,2-a]pyridin-3-ylpropionamide fragments was suggested, which consisted of the reaction of N-methyl-N-(2-trifluoromethylimidazo[1,2-a]pyridin-3-yl)prop-2-enamides with γ-carbolines in the presence of catalytic amounts of cesium fluoride. Method of radioligand binding was used to study effects of the synthesized 3-(1,2,3,4-tetrahydro-5H-pyrido[4,3-b]-indol-5-yl)-N-methyl-N-[2-(trifluoromethyl)imidazo-[1,2-a]pyridin-3-yl]propanamides on the neuronal NMDA-receptors.
Russian Chemical Bulletin | 2016
V. B. Sokolov; A. Yu. Aksinenko; T. V. Goreva; T. A. Epishina; V. V. Grigor’ev; A. V. Gabrel´yan; D. V. Vinogradova; Ludmila G. Dubova; Pavel N. Shevtsov; E. F. Shevtsova; S. O. Bachurin
Earlier unknown conjugates of carbazoles and γ-carbolines were obtained by the reaction of 3,6-substituted 9-oxiranylmethylcarbazoles and 2,8-substituted 2,3,4,5-tetrahydro-1H-pyrido-[4,3]indoles. The effects of synthesized 1-(9H-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5H-pyrido-[4,3-b]indol-5-yl)propan-2-ones and their hydrochlorides on neuronal NMDA receptors, polymerization of tubulin to form microtubules, and functional characteristics of rat liver mitochondria were studied.
Russian Chemical Bulletin | 2015
S. O. Bachurin; V. B. Sokolov; A. Yu. Aksinenko; T. A. Epishina; T. V. Goreva; A. V. Gabrel´yan; V. V. Grigor’ev
Synthetic strategy to access new multitarget neuroprotectors by conjugation of pharma-cophoric indole and bis(dimethylamino)phenothiazine moieties via 1-oxopropylene spacer was developed. The transformation was achieved by the cesium fluoride-catalyzed reaction of cycloalkaneindoles with 1-propenone. Effect of the synthesized compounds on neuronal NMDA receptors was evaluated by radioligand binding assay.
Russian Journal of General Chemistry | 2013
A. N. Yarkevich; Z. V. Safronova; L. N. Petrova; A. V. Gabrelyan; V. L. Zamoyski; V. V. Grigor’ev; S. O. Bachurin; Nikolai S. Zefirov
Bis(dialkylamides) of phosphoryl-substituted α,ω-dicarboxylic acids were synthesized and their biological activity was studied.
Pharmaceutical Chemistry Journal | 2012
Mstislav Igorevich Lavrov; Vera L. Lapteva; V. V. Grigor’ev; V. A. Palyulin; S. O. Bachurin; N. S. Zefirov
A series of amides of benzodioxane-6-carboxylic and piperonylic acids have been synthesized. Biological studies showed that some of the synthesized compounds influence the central nervous system (in particular, AMPA receptors).
Chemistry of Natural Compounds | 2008
S. G. Klochkov; S. V. Afanas’eva; V. V. Grigor’ev
A method for stereospecific synthesis of allomargaritarin and other amination products of the natural alkaloid securinine was developed. Stereoselective nucleophilic addition of an amine at the double bond of the azobicyclooctane moiety of securinin was achieved by using ytterbium triflate as the catalyst. The biological activity of securining caused by adding pharmacophores to the molecule was shown to change experimentally.
Bulletin of Experimental Biology and Medicine | 2006
V. V. Grigor’ev; T. A. Ivanova; E. A. Kustova; L. N. Petrova; T. P. Serkova; S. O. Bachurin
We studied the effect of delta sleep-inducing peptide on GABA receptors of hippocampal and cerebellar neurons in rats. It was shown that delta sleep-inducing peptide considerably and dose-dependently potentiates GABA-activated currents in these neurons and blocks NMDA-activated potentiation in cortical and hippocampal neurons. The peptide modulates activity of presynaptic NMDA receptors, which is seen from changes in 45Ca2+ uptake into synaptosomes of the brain cortex after uptake stimulation with glutamate and NMDA.
Russian Journal of General Chemistry | 2015
V. B. Sokolov; A. Yu. Aksinenko; T. A. Epishina; T. V. Goreva; A. V. Gabrel´yan; O. A. Dranii; V. V. Grigor’ev; S. O. Bachurin
Modification of biologically active cycloalkaneindoles by incorporation of a 2-trifluoromethylimidazo[1,2-a]pyridin-6-yl fragment has been proposed and performed via the interaction with 3-fluoro-2-trifluoromethylimidazo[1,2-a]pyridines in the presence of potassium hydroxide. The action of the prepared compounds on neuronal NMDA receptors has been studied by means of radioligand binding.